No abstract available.
Snake Bites* ; Snakes*

PURPOSE: Various factors have been cited in the morbidity of small bowel resections, but their clinical importance is uncertain. We wanted to know what were the significant risk factors elevating the morbidity and how to reduce the morbidity of small bowel resections effectively. METHODS: A retrospective study was done for 107 patients who had undergone small bowel resections from Jan. 1992 to Jul. 1999. The patients were evaluated based on sex and age, the cause and site of resection, the presence of previous abdominal operations, the morbidity, the mortality, and the cause of death in order to determine their clinical significance for small bowel resections. Also the differences of morbidity were analyzed according to the risk factors of old age, pre-op hypotension and hypoalbuminemia, the cause of resection, emergency operation, the presence of a previous abdominal operation, the length of the resection, the presence of associated chronic illness, and spillage of the intestinal content. RESULTS: Complications after small bowel resections occurred in 41 cases (38.3%). The morbidity was significantly increased in the cases with associated chronic illness and spillage of intestinal content by perforation combined with strangulation (p<0.05). Factors such as old age, hypotension, hypoalbuminemia, cause of resection, emergency operation, the length of the resection and spillage of intestinal contents by simple perforation elevated the morbidity, but this result is not statistically significant (0.050.5). CONCLUSIONS: We concluded that intensive peri-operative care, a rapid and precise operative technique, and the surgeon's efforts can decrease the morbidity and the mortality after small bowel resections. The selection of the high risk patients should be done based on the surgeon's knowledge of the risk factors including associated chronic illness, and cumulative data obtained by using instituted surveillance for morbidity.
Cause of Death ; Chronic Disease ; Emergencies ; Gastrointestinal Contents ; Humans ; Hypoalbuminemia ; Hypotension ; Mortality ; Retrospective Studies ; Risk Factors*

Primary hyperparathyroidism is rarely encountered during pregnancy but its prompt diagnosis and treatment if encountered during pregnancy is important because it can carry considerable morbidity not only for the mother but also for the fetus. It tends to remain undiagnosed because 50~80% of the patients are asymptomatic. Even if they do demonstrate symptoms, those are often nonspecific. The other reason for non-diagnosis is masking of hypercalcemia due to the change of calcium homeostasis during pregnancy. Neonatal tetany can be a clue for the presence and diagnosis maternal hyperparathyroidism. The asymptomatic patient who is diagnosed postpartum when her newborn is symptomatic should undergo elective parathyroidectomy to avoid future complication. We experienced a woman with undiagnosed primary hyperparathyroidism during pregnancy whose two children suffered neonatal tetany. We report this case along with a review of literature on primary hyperparathyroidism in pregnancy and calcium homeostasis during pregnancy.
Calcium ; Child ; Diagnosis ; Female ; Fetus ; Homeostasis ; Humans ; Hypercalcemia ; Hyperparathyroidism* ; Hyperparathyroidism, Primary ; Infant, Newborn ; Masks ; Mothers ; Parathyroidectomy ; Postpartum Period ; Pregnancy* ; Tetany*

No abstract available.
Hand Deformities ; Humans ; Parkinsonian Disorders*

No abstract available.
Hepatocyte Growth Factor* ; Hepatocytes* ; Placenta* ; Pre-Eclampsia*

Exogenous glucocorticoid has anti-inflammatory effect to reduce symptoms and signs of rheumatoid arthritis. However there are few reports about the role of endogenous glucocorticoid in rheumatoid arthritis. Recently we experienced a case of rheumatoid arthritis developed in a female patient with Cushing's disease as her cortisol level decreased during medical management of hypercortisolemia. She underwent trans-sphenoidal surgery for Cushing's disease (pituitary microadenoma). Six years after surgery she had disease recurrence and received brain radiotherapy and ketoconazole medication. Four years later she developed seronegative rheumatoid arthritis. 24 hour urine cortisol level was below the normal value at that time. Polyarthralgia improved with prednisolone (5mg/day). But polyarthralgia was aggravated as cortisol level decreased below the normal value after prednisolone was discontinued. This case and previous reports suggest that the development and aggravation of rheumatoid arthritis is associated with relative cortisol deficiency, or alteration of balance between neuroendocrine system(hypothalamic- pituitary-adrenal axis) and inflammatory process.
Arthralgia ; Arthritis, Rheumatoid* ; Brain ; Female ; Humans ; Hydrocortisone ; Ketoconazole ; Prednisolone ; Radiotherapy ; Recurrence ; Reference Values

The morphological changes in the anterior horn of the L4 and L5 spinal segments were observed following anterior root avulsion in the adult male Sprague-Dawley rat (300~350 gm) at 5 days, 1 week, 2 weeks and 3 weeks postlesion. The animals were perfused with 4% paraformaldehyde, 0.15% picric acid in 0.1 M phosphate buffer solution and cryostat sections were prepared. Immunohistochemistry was used to identify changes of the phenotype in the anterior horn cells. Primary antibodies, goat anti-choline acetyltransferase (ChaT, 1 : 500, Chemicon), mouse antirat ED-1 (1 : 200, Serotec), rabbit anti-glial fibrillary acidic protein (GFAP, 1 : 200, DAKO) and rabbit anti-vascular endothelial growth factor (VEGF, 1 : 500, Santa Cruz Biotechnology) were used. Avidin-Biotin complex method was performed for immunohistochemical reaction and color reaction was developed with DAB-H2O2. Following results were observed in the anterior horn of lumbar spinal cord; 1. The number of ChaT-immunoreactive (ir) cells were reduced 20% level of control animals at 3 weeks after avulsion. 2. ED-1-ir microglia were significantly increased at 1 week and processes of ED-1-ir microglia surrounded around the axotomized neuronal cell bodies. 3. Gliosis defined by extensive GFAP immunoreactivity was observed both ipsilateral and contralateral side of lesion but the VEGF-ir cells were significantly increased in the ipsilateral side of lesion. Therefore, this study suggested that the majority of axotomized motor neurons were degenerated and the cellular proliferation and phenotype changes including glial cell activation were observed in the lumbar spinal cord after anterior root avulsion of adult rats.
Adult* ; Animals ; Anterior Horn Cells* ; Antibodies ; Cell Proliferation ; Choline O-Acetyltransferase ; Endothelial Growth Factors ; Gliosis ; Goats ; Horns ; Humans ; Immunohistochemistry ; Male ; Mice ; Microglia ; Motor Neurons ; Neuroglia ; Neurons ; Phenotype ; Rats* ; Rats, Sprague-Dawley ; Spinal Cord* ; Vascular Endothelial Growth Factor A

No abstract available.
Placenta*

Chios gum mastic (CGM) is a resinous exudate obtained from the stem and the main leaves of Pistacia lenticulus tree native to Mediterranean areas. Recently, it was reported that CGM induced apoptosis in a few cancer cells in vitro. Since recent studies indicated the synergistic interactions between the apoptotic stimulus and a proteasome inhibitor, the ubiquintin-proteasome pathway has become an attractive target in cancer therapy. And to date, there has been no report of the synergistic apoptotic effect between CGM and a proteasome inhibitor to become an attractive target in cancer therapy. Therefore, this study was undertaken to investigate the synergistic apoptotic effect of co-treatment with a natural product, CGM, and a proteasome inhibitor, lactacystin, on human osteosarcoma (HOS) cells. To investigate whether the co-treatment of CGM and lactacystin compared with each single treatment efficiently induced apoptosis on HOS cells, MTT assay, DNA electrophoresis, Hoechst staining, DNA hypoploidy assay, Westen blot analysis, immunofluorescent staining, proteasome activity and mitochondrial membrane potential (MMP) change were performed. In this study, HOS cells co-treated with CGM and lactacystin showed several lines of apoptotic manifestation such as nuclear condensation, DNA fragmentation, the reduction of MMP and proteasome activity, the decrease of DNA content, the release of cytochrome c into cytosol, the translocation of AIF and DFF40 (CAD) onto nuclei, and activation of caspase-7, caspase-3, PARP and DFF45 (ICAD) whereas each single treated HOS cells hardly showed. We presented data indicating that the co-treatment of CGM and lactacystin induced potentially apoptosis whereas each single treatment did slightly. Moreover, the co-treatment of CGM and lactacystin potentiated the inhibition of proteasome activity. Therefore, our data provide the possibility that combination therapy of CGM and lactacystin could be considered as a novel therapeutic strategy for human osteosarcoma.
Acetylcysteine ; Apoptosis ; Caspase 3 ; Caspase 7 ; Cytochromes c ; Cytosol ; DNA ; DNA Fragmentation ; Electrophoresis ; Exudates and Transudates ; Gingiva ; Humans ; Membrane Potential, Mitochondrial ; Osteosarcoma ; Pistacia ; Proteasome Endopeptidase Complex ; Proteasome Inhibitors ; Resins, Plant ; Trees

No abstract available.
Arthritis, Psoriatic* ; HLA-B27 Antigen ; Korea* ; Prevalence* ; Psoriasis ; Spondylitis