The amplitude of accommodation of 490 normal Koreans aged 6 to 70 was measured with minus lens to blur technique. Duane's single, fine thread target was used. The result was divided into 13 age-groups as follows: 1. The age group of 6 to 10: The range was 16.25 D to 11.50 D, the median 14.50 D and mean 14.55 D. 2. The age group of 11 to 15: The range was 16.25 D to 11.00 D, the median 12.5O D and the mean l2.36 D. 3. The age group 16 to 20: The range was 13.5O D to 8.75 D, the median 10.50 D and the mean 10.75 D. 4. The age group of 21 to 25: The range was 12.00 D to 5.5O D, the median 9.00 D and the mean 8.86 D. 5. The age group of 26 to 30: The range was 9.25 D to 6.00 D, the median 7.5O D and the mean 7.25 D. 6. The age group of 31 to 35; The range was 7.5O D to 4.75 D, the median 6.00 D and the mean 6.10 D. 7. The age group of 36 to 40: The range was 6.00 D to 4.00 D, the median 5.00 D and the mean 4.9O D. 8. The age group of 41 to 45: The range was 5.25 D to 2.00 D, the median 3.75 D and the mean 3.81 D. 9. The age group of 46 to 50: The range was 4.75 D to 1.75 D, the median 2.75 D and the mean 2.84 D. 10. The age group of 51 to 55: The range was 3.00 D to 1.00 D, the median 2.00 D and the mean 2.06 D. 11. The age group of 56 to 60: The range was 2.00 D to 0.5O D, the median 1.50 D and the mean 1.34 D. 12. The age group of 61 to 65. The range was 1.55 to 0.00 D, the median 0.75 D and the mean 0.72 D. 13. The age group of 66 to 70. The range was 0.5O D to 0.00 D, the median 0.25 D and the mean 0.21 D. Amplitude of accommodation is found to be gradually decreasing with the advancing age and no sudden decrease was noted. The results are similar to those of Donder's. Compared with Duane's, my results showed a slightly higher value below age of 10 and slightly lower value above age of 15.
Humans ; Reference Values*

Trichophyton verrucosum is a worldwide zoophilic dermatophye. The human infection was first reported in t.he South western part of Korea in 1986 and Fas been increasing in Taegu area. Thirty-one strains of T. verrucosum isolated from the patients in Taegu area were investigated for their mycological features. Gross observation on Sabot rauds dextrose agar, microscopic examination by scotch tape method and slide culture or Sabourauds dextrose agar and potato dextrose agar, and hair perforation test were perforn ed at 37C. The averages of the largest dimensions of the colonies were .9mm at 2 weeks and 59mm at 4 weeks. The morphologic features of the colonies were clasified into three types. Eighteen of 31 strains showed flatwhitish, disc-like colonies with suvmerging hyphae, 11 strains had large radiating follows on the center of the colonies, and 2 strains showed colonies having diffuse fine folds on their surfaces with well-defined borders. On microscopic exaniination, many chlamydospores, antlerlive hyphae, oval and clavate microconidia, and rat tail or string bean shaped macroconidia were observed. It seemed that observation on potato dextrose agar during 10 to 14 days af er inoculation was suitable method for microscopic examination of T. verrucosum. All 31 strains showed positive reaction on hair perforation test.
Agar ; Animals ; Daegu* ; Glucose ; Hair ; Humans ; Hyphae ; Korea ; Rats ; Solanum tuberosum ; Tail ; Trichophyton*

The author investigated the distribution of sex and age, site of affected eye, numbers of leaking point, recurrent rate and detached size, leaking site, onset and visual acuity of each type of 104 cases of retinal fluorescein angiographic findings of central serous retinopathy of Ophthalmic Department of Hanyang University Hospital from April 1978 to March 1979. Each type according to the leaking pattern on fluorescein angiography are characteristically 'classified as follows: Type A; Leaking point was unremarkable (C.S.R. clinically). Type B; Leaking point appeared at early arterial phase and increased in density gradually but the size of leaking area was not changed (R.P.E. detachment). Type C; Leaking point appeared at early arterial phase and increased concentrically in the density and size (round serous detachment). Type D; Leaking point appeared at early arterial phase and increased vertically in the density and size (mushroom-shaped serous detachment). Type E; Retinal hyperfluorescent was appeared at early arterial phase but gradually fade out (scar formation). The results are as follows: 1) Male was more frequently affected (94.2%). 2) Third and fourth decades were more frequently affected (89.2%). 3) Unilateral involvement was noted (94.2%) without difference of both eyes. 4) In each eye, one leaking point was most frequently observable (65.9%). 5) The recurrent rate was frequently observable on fluorescein angiographic findings (40.4%). 6) The detached size of type B was limitted under the one disc diameter and the detached size of type C and D especially type D was more larger than type B. 7) The site of leaking point had tendency to be located superiorly without significant differences of each type (superior area; 43.6%, macular area; 38.4%, and inferior area; 17.8%). 8) Comparing the onsets of each type, type D and A could be seen within 3 months, and type B could be observable within six months, but the other types could be found from one week to over one year. 9) In general, the visual acuity was severely disturbed in type D rather than the other types. And the visual disturbance was remarkable in the case of macular involvement and large serous detachment.
Central Serous Chorioretinopathy* ; Fluorescein Angiography ; Fluorescein* ; Humans ; Male ; Retinaldehyde ; Visual Acuity

Intrabronchial nerilemmoma is very rare disease. Neurilemmoma has been thought to arise from schwann cell, has been reported to occur in almost any anatomic location. The incidence of primary neurogenic tumors of the lung has been estimated to be 0 to 2 percent of all lung tumors. These tumors are predominantly(75%) associated with neurofibromatosis of von Recklinghausen's disease. To our knowledge, no case of benign solitary endobronchial neurilemmoma has been reported in Korea. This paper presents a case of benign solitary endobronchial neurilemmoma with a brief review of the pertinent literature. A 19 year old female visited our medical hospital with the symptoms of chest discomfort and pain. Bronchoscopy and chest CT scan revealed a mass on the left upper 1obar bronchus. Left upper lobectomy was performed successfully and histological section revealed a neurilemmoma.
Bronchi ; Bronchoscopy ; Female ; Humans ; Incidence ; Korea ; Lung ; Neurilemmoma* ; Neurofibromatoses ; Neurofibromatosis 1 ; Rare Diseases ; Thorax ; Tomography, X-Ray Computed ; Young Adult

Death by drowning is one of the most common cause of death worldwide, and the diagnosis of fatal drowning through postmortem examination is not always confirmative. Although many autopsy findings of drowning have been described so far, all these macroscopical signs are non-specific and moreover disappear quite rapidly in the process of decomposition. The combination of autopsy findings and diatom test can provide useful indication for the tentative diagnosis of drowning, but the value of the diatom analysis is still argued. The aim of the present study is to investigate the diagnostic usefulness of diatom test for the drowning death in Korea. The authors reviewed the result of 87 cases of diatom test in the autopsy file and analyzed it by parameters of the common diatom species, monthly frequency, the difference between sea and land water, and the correlation between the test result and the decision of cause of death. The result revealed no definite seasonal variation of diatom detection or no species difference between sea water cases and fresh water cases. The detection rate of diatoms in systemic organs of all cases was 11.49% and that of drowning cases was 9.43%.
Autopsy ; Cause of Death ; Diatoms ; Drowning ; Fresh Water ; Korea ; Seasons ; Seawater ; Water

We have experienced a case of aortic dissecting aneurysm in pregnant woman. She felt initially severe chest pain which was radiated to the neck on the 3days before delivery. Thereafter dyspnea and generalized edema were developed for 1 month after delivery. She was diagnosed as aortic dissectLn, Debakey type-II. During cardiopulmonary bypass, the selective cerebral perfusion was done through the right and left commom carotid arteries. Aortic replacement with Hemashield vascular graft and reimplantation of innominate artery, resuspension of aortic valve, repair of intimal tear were performed. The postoperative course was uneventful.
Aneurysm, Dissecting ; Aortic Valve ; Brachiocephalic Trunk ; Cardiopulmonary Bypass ; Carotid Arteries ; Chest Pain ; Dyspnea ; Edema ; Female ; Humans ; Neck ; Perfusion ; Pregnant Women* ; Replantation ; Tears ; Transplants

Nonvisualization of left circumflex coronary artery from the left coronary artery is commonly due to anomalous origin of circumflex artery from the right coronary artery or right sinus of Valsalva. However, complete ostial obstruction of circumflex artery, circumflex artery extended from the right coronary artery, anomalous origin of circumflex artery from the pulmonary artery may be the cause. We report two cases of absent left circumflex artery from the left coronary artery, in which the circumflex artery arose as a terminal extension of the right coronary artery. Angiographic features of absent left circumflex artery from the left coronary artery were described.
Arteries* ; Coronary Vessels* ; Pulmonary Artery ; Sinus of Valsalva

The aim of this study was to determine the beneficial effect of propofol on human keratinocytes that have undergone hypoxia reoxygenation (H/R) injury and to investigate whether autophagy is associated with the protective mechanism. Thus, we evaluated how propofol influences the intracellular autophagy and apoptosis during the H/R process in the HaCaT cells. The cultured human keratinocyte cells were exposed to 24 h of hypoxia (5% CO2, 1% O2, 94% N2) followed by 12 h of reoxygenation (5% CO2, 21% O2, 74% N2). The experiment was divided into 4 groups: (1) Control=Normoxia ; (2) H/R=Hypoxia Reoxygenation ; (3) PPC+H/R=Propofol Preconditioning+Hypoxia Reoxygenation; (4) 3-MA+PPC+H/R=3-MA-Methyladenine+Propofol Preconditioning+Hypoxia Reoxygenation. In addition, Western blot analysis was performed to identify the expression of apoptotic pathway parameters, including Bcl-2, Bax, and caspase 3 involved in mitochondrial-dependent pathway. Autophagy was determined by fluorescence microscopy, MDC staining, AO staining, and western blot. The H/R produced dramatic injuries in keratinocyte cells. In our study, the viability of Propofol in H/R induced HaCaT cells was first studied by MTT assay. The treatment with 25, 50, and 100 microM Propofol in H/R induced HaCaT cells enhanced cell viability in a dose-dependent manner and 100 microM was the most effective dose. The Atg5, Becline-1, LC3-II, and p62 were elevated in PPC group cells, but H/R-induced group showed significant reduction in HaCaT cells. The Atg5 were increased when autophagy was induced by Propofol, and they were decreased when autophagy was suppressed by 3-MA. These data provided evidence that propofol preconditioning induced autophagy and reduced apoptotic cell death in an H/R model of HaCaT cells, which was in agreement with autophagy playing a very important role in cell protection.
Anoxia ; Apoptosis ; Autophagy ; Blotting, Western ; Caspase 3 ; Cell Death ; Cell Survival ; Cytoprotection ; Humans ; Keratinocytes* ; Microscopy, Fluorescence ; Propofol*

This report deals with the acute onset of an abortion outbreak and high sow mortality in one pig herd consisted of 1,200 pigs and 120 sows on Jeju Island, Korea. Affected pregnant sows showed clinical signs, including high fever, gradual anorexia, vomiting, depression, recumbency, prostration, abortion, and a few deaths. Four dead sows, five aborted fetuses from the same litter, and 17 sera collected from sows infected or normal were submitted to the Pathology Division of the National Veterinary Research and Quarantine Service for diagnostic investigation. Grossly, hepatomegaly and splenomegaly were observed in sows. Multiple necrotic foci were scattered in the lungs, liver, spleen, and lymph nodes. Microscopically, multifocal necrotizing lesions and protozoan tachyzoites were present in the lesions. Tachyzoites of Toxoplasma (T.) gondii were detected immunohistochemically. Latex agglutination showed that the sera of 7 of 17 (41.2%) sows were positive for antibody to T. gondii. The disease outbreak in this herd was diagnosed as epizootic toxoplasmosis. To our knowledge, this is the first report of porcine toxoplasmosis with a high abortion rate and sow mortality in Korea.
Aborted Fetus ; Abortion, Veterinary/blood/epidemiology/*parasitology/pathology ; Animals ; Antibodies, Protozoan/blood ; Disease Outbreaks/*veterinary ; Female ; Hepatomegaly/parasitology/veterinary ; Immunohistochemistry/veterinary ; Korea/epidemiology ; Latex Fixation Tests/veterinary ; Pregnancy ; Splenomegaly/parasitology/veterinary ; Swine ; Swine Diseases/blood/epidemiology/*parasitology/pathology ; Toxoplasma/*isolation & purification ; Toxoplasmosis, Animal/blood/epidemiology/parasitology/*pathology

BACKGROUND: Oxidative stress occurs during the aging process and other conditions such as bone fracture, bone diseases, and osteoporosis, but the role of oxidative stress in bone remodeling is unknown. Propofol exerts antioxidant effects, but the mechanisms of propofol preconditioning on oxidative stress have not been fully explained. Therefore, the aim of this study was to evaluate the protective effects of propofol against H2O2-induced oxidative stress on a human fetal osteoblast (hFOB) cell line via activation of autophagy. METHODS: Cells were randomly divided into the following groups: control cells were incubated in normoxia (5% CO2, 21% O2, and 74% N2) without propofol. Hydrogen peroxide (H2O2) group cells were exposed to H2O2 (200 µM) for 2 h, propofol preconditioning (PPC)/H2O2 group cells were pretreated with propofol then exposed to H2O2, 3-methyladenine (3-MA)/PPC/H2O2 cells were pretreated with 3-MA (1 mM) and propofol, then were exposed to H2O2. Cell viability and apoptosis were evaluated. Osteoblast maturation was determined by assaying bone nodular mineralization. Expression levels of bone related proteins were determined by western blot. RESULTS: Cell viability and bone nodular mineralization were decreased significantly by H2O2, and this effect was rescued by propofol preconditioning. Propofol preconditioning effectively decreased H2O2-induced hFOB cell apoptosis. However, pretreatment with 3-MA inhibited the protective effect of propofol. In western blot analysis, propofol preconditioning increased protein levels of collagen type I, BMP-2, osterix, and TGF-β1. CONCLUSIONS: This study suggests that propofol preconditioning has a protective effect on H2O2-induced hFOB cell death, which is mediated by autophagy activation.
Aging ; Antioxidants ; Apoptosis ; Autophagy* ; Blotting, Western ; Bone Diseases ; Bone Remodeling ; Cell Death ; Cell Line ; Cell Survival ; Collagen Type I ; Fractures, Bone ; Humans* ; Hydrogen Peroxide ; Miners ; Osteoblasts* ; Osteoporosis ; Oxidative Stress* ; Propofol