1.The Skeletal Site-Differential Changes in Bone Mineral Density Following Bone Marrow Transplantation: 3-Year Prospective Study.
Won Young LEE ; Moo Il KANG ; Ki Hyun BAEK ; Eun Sook OH ; Ki Won OH ; Kwang Woo LEE ; Sun Woo KIM ; Choon Choo KIM
Journal of Korean Medical Science 2002;17(6):749-754
Loss of bone mass is usually detected after bone marrow transplantation (BMT) during the early post-transplant period. However, little is known about the long-term effects of BMT on bone metabolism. We have prospectively investigated 11 patients undergoing BMT. Bone mineral density (BMD) was measured before BMT, and 1, 2, and 3 yr after BMT. Serum markers of bone turnover were serially measured before BMT and 1, 2, 3, 4, and 12 weeks, 6 months, and 1 yr after BMT. The mean change in the lumbar spine (L2-4) BMD, calculated as the percent change from the baseline to the level at 1, 2, and 3 yr was -4.7% (NS), -1.1% (NS), and +6.4% (p<0.05), respectively. The mean change in the total proximal femur BMD from the baseline to the level at 1, 2, and 3 yr was -8.5% (p<0.01), -8.7% (p<0.05) and -5.6% (p<0.05), respectively. In summary, there was little decline in lumbar BMD at 1 yr following BMT and gradual recovery until 3 yr. In contrast, femoral BMD decreased much more than the lumbar area at 1 yr and did not recover until 3 yr. The mechanism of skeletal site-selective differences in the changes of BMD needs to be elucidated.
Adult
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Age Factors
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Anemia, Aplastic/therapy
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*Bone Density
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Bone Marrow Transplantation
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Bone and Bones/drug effects/*metabolism/radiation effects
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Collagen/blood
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Collagen Type I
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Cyclophosphamide/therapeutic use
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Estradiol/blood
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Follicle Stimulating Hormone/blood
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Humans
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Leukemia/therapy
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Luteinizing Hormone/blood
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Middle Aged
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Myelodysplastic Syndromes/therapy
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Peptides/blood
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Prospective Studies
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Time Factors