Bone and Bones/diagnostic imaging* ; Breast/diagnostic imaging* ; Breast Neoplasms/diagnostic imaging* ; Female ; Humans

Bone Neoplasms/therapy* ; Humans ; Temporal Bone/diagnostic imaging*

Bone Neoplasms ; diagnostic imaging ; pathology ; Female ; Humans ; Middle Aged ; Osteoma ; diagnostic imaging ; pathology ; Palate ; diagnostic imaging ; pathology ; Radiography

OBJECTIVETo evaluate the diagnostic criteria and morphologic difference of primary schwannoma from that of soft tissue schwannoma.

METHODSAll neurogenic tumors of the bone in this hospital from 2002 to 2013 were reviewed, four cases of primary schwannoma arising from bone were selected. Their clinical features, radiologic appearance and pathologic findings were evaluated. Immunophenotyping was performed using EnVision method.

RESULTSAll four cases had classic morphologic features and immunophenotype of conventional schwannoma. Compared with schwannoma of the soft tissue, primary bone schwannoma had the following features: benign radiological appearance, absence of capsule under light microscope, local infiltration of bone or destruction of bone cortex, occasionally involving extra-osseous soft tissue. Most tumors were solid, with less cystic degeneration. Histologically, the tumors were mainly composed of compact areas of spindle cells (Antoni A), and areas of hypercellularity could often be observed.

CONCLUSIONSPrimary schwannoma of the bone is rare, usually arises within the long bones and flat bones. Compared to conventional soft tissue schwannoma, it shows different growth pattern, imaging and pathologic features; thus care should be exercised not to misdiagnose schwannoma of the bone as other primary low-grade malignant spindle cell sarcoma of the bone and to avoid unnecessary over-treatment.

Bone Neoplasms ; diagnosis ; diagnostic imaging ; pathology ; Humans ; Immunophenotyping ; Neurilemmoma ; diagnosis ; diagnostic imaging ; pathology ; Radiography ; Sarcoma ; diagnosis ; diagnostic imaging ; pathology

OBJECTIVETo study the clinical characteristics and the prognosis of solitary bone plasmacytoma (SBP).

METHODSFrom June 1997 to June 2002, ten SBP patients were treated in our department. Two lesions were in sacrum, two in pelvis, the other six lesions were in proximal femur, femoral diaphyseal, scapula, thoracic vertebra, proximal humus, and rib respectively. The preoperative laboratory tests were normal. Operation was performed on all patients. The pathologic diagnose was plasmacytoma and then they underwent further laboratory examination, urine Bence-Jone protein is positive in 3 patients, serous IgG value was higher than normal in 2 patients, abnormal M protein was found in electrophoresis in 2 patients. All patients received radiotherapy postoperatively.

RESULTSFour patients were excluded, whose follow-up were lessen than ten months, the other six patients's average follow-up is 28.2 months (from 18 to 48 months), one patient who developed multiple myeloma (MM) six months postoperatively received chemotherapy using M2 protocol and died 21 months after operation. The other five patients had disease-free survive and remain solitary bone lesion after the treatment of surgery and radiology.

CONCLUSIONCompared with MM, SBP patients are younger, the therapeutic results and prognosis are better. The main prognostic factors include age, the size of lesion, the axial bone lesion, persistence of myeloma protein after radiotherapy, early diagnosis and treatment, and so on.

Bone Neoplasms ; diagnostic imaging ; surgery ; Female ; Humans ; Male ; Middle Aged ; Plasmacytoma ; diagnostic imaging ; surgery ; Prognosis ; Radiography

Clear cell chondrosarcoma is a rare cartilaginous tumour of low-grade malignancy. Although it has a characteristic histological appearance, its radiological features and clinical presentation often mimic a benign lesion. Herein, we describe the case of a patient with a clear cell chondrosarcoma of the right proximal femur that had an atypical appearance of chronic avascular necrosis on initial plain radiographs, which made preoperative diagnosis a challenge. In addition, the tumour also had extensive areas of aneurysmal bone cyst-like changes, which is not only a rare histologic phenomenon in clear cell chondrosarcoma, but also a confounding factor in the interpretation of the radiologic findings.
Adult ; Bone Cysts, Aneurysmal ; complications ; diagnostic imaging ; Bone Neoplasms ; complications ; diagnostic imaging ; Chondrosarcoma ; complications ; diagnostic imaging ; Female ; Femur ; diagnostic imaging ; pathology ; Hip ; pathology ; Humans ; Magnetic Resonance Imaging ; Necrosis ; pathology ; Osteoarthritis ; diagnostic imaging ; Radiography ; Whole Body Imaging

INTRODUCTIONThis study aimed to evaluate radiological findings in patients with chondroblastoma (CB) in tubular and non-tubular bones (NTBs).

METHODSWe retrospectively reviewed the medical records of patients with CB. Data collected included patients' gender and age, type, size and location of bone involved, and imaging findings regarding border, lobulation, calcification, trabeculation, cortical expansion and destruction, periosteal reaction, soft tissue component and fractures. Magnetic resonance imaging and/or multidetector computed tomography were used to determine the presence of any internal cystic space or secondary aneurysmal bone cyst that may have affected the radiological appearance of CB.

RESULTSAll 31 lesions (18 tubular bones, 13 NTBs) exhibited geographic bone destruction and did not involve the adjacent joints. Univariate analysis showed that NTB lesions were found in older patients and were associated with thin trabeculation (p < 0.01) and well-defined margins (p < 0.05), whereas tubular bone lesions correlated with thick trabeculation and partially ill-defined margins. On multivariate analysis, age and type of bone involvement were significantly correlated. An increase in age by one year reduced the risk of having tubular bone involvement by about 27% when compared with NTBs (p = 0.011). Thin trabeculation was also significantly correlated with NTB lesions.

CONCLUSIONAge was the most significant parameter, as increased age was found to reduce the risk of tubular bone involvement. Patients with NTB lesions were significantly older than those with tubular bone lesions. Based on imaging alone, thin trabeculation showed significant correlation with CB occurring in NTBs on both univariate and multivariate analyses.

Adolescent ; Adult ; Bone Cysts, Aneurysmal ; diagnosis ; diagnostic imaging ; Bone Neoplasms ; diagnosis ; diagnostic imaging ; Bone and Bones ; diagnostic imaging ; pathology ; Child ; Chondroblastoma ; diagnosis ; diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Multidetector Computed Tomography ; Multivariate Analysis ; Reproducibility of Results ; Retrospective Studies ; Young Adult

OBJECTIVESTo evaluate the clinical significance of PSA and ECT bone scans in the diagnosis of bone metastasis in prostate cancer patients.

METHODSSixty-seven cases of prostate cancer were reviewed, bone metastasis (BM) occurred in 44 cases, and 23 cases without BM (NBM). The relation between PSA, ECT and bone metastasis was analyzed.

RESULTSThe sensitivity of BM with bone scan of ECT was 91.67%. Single local density of radionuclide with bone scan was found in 6 cases, only 2 cases have BM. The value of PSA between BM and Non-BM group had significant difference (87.28 micrograms/L vs 25.37 micrograms/L, P < 0.01). PSA and the degree of bone metastasis was positively correlated. PSA < 10 micrograms/L, the morbidity of BM was 0; PSA 10-20 micrograms/L, 7.69%; PSA 20-60 micrograms/L, 53.33%; PSA 60-100 micrograms/L, 91.67%; and PSA > 100 micrograms/L, 100%.

CONCLUSIONSECT is a high sensitive method in diagnosis of bone metastasis of prostate cancer, but it is not specific in patients with single focus of BM. As for those patients of prostate cancer without any treatment, while PSA < 10 micrograms/L, the morbidity of BM is rare; while PSA > 100 micrograms/L, BM is in high suspect.

Bone Neoplasms ; diagnostic imaging ; secondary ; Humans ; Male ; Prostate-Specific Antigen ; blood ; Prostatic Neoplasms ; diagnosis ; diagnostic imaging ; Tomography, Emission-Computed

Arthrography ; Bone Neoplasms ; diagnosis ; diagnostic imaging ; pathology ; Bone and Bones ; diagnostic imaging ; pathology ; Diagnosis, Differential ; Diagnostic Errors ; Humans ; Immunohistochemistry ; Joint Diseases ; diagnosis ; diagnostic imaging ; pathology ; Joints ; diagnostic imaging ; pathology ; Radionuclide Imaging

The diagnosis of bone metastasis of prostate cancer (PC) is of great significance to the treatment and prognosis of patients with PC.Bone scan is the most commonly used in the early diagnosis of bone metastasis, but its specificity is low and there is a high false positive.In recent years, with the in-depth study of the application of CT, MRI, emission computed tomography (ECT), positron emission computed tomography/computed tomography (PET/CT) and deep learning algorithm-convolutional neural networks (CNN) in the diagnosis of bone metastasis, the combined application of various auxiliary parameters in the diagnosis of bone metastasis has significantly been improved. The therapeutic effect of PC patients with bone metastasis can also be evaluated, which is expected to achieve the treatment of bone metastasis as well as diagnosis. By systematically expounding the research progress of the above-mentioned techniques in the diagnosis of bone metastasis, it can provide clinicians with new methods for the diagnosis of bone metastasis and improve the diagnostic efficiency for bone metastasis.
Bone Marrow Diseases ; Bone Neoplasms/diagnostic imaging* ; Humans ; Magnetic Resonance Imaging ; Male ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/diagnostic imaging*