1.Purification of porcine bone morphogenetic protein.
Nam Hyun KIM ; Kyu Hyun YANG ; Hwan Mo LEE ; Sang Hwan OH
The Journal of the Korean Orthopaedic Association 1991;26(1):232-238
No abstract available.
Bone Morphogenetic Proteins*
2.The experimental study on the effect of pulsating electromagnetic fields in the osteoinduction induced by bone morphogenetic protein.
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1993;19(3):412-426
No abstract available.
Bone Morphogenetic Proteins*
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Electromagnetic Fields*
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Magnets*
3.Postulated release profile of recombinant human bone morphogenetic protein-2 (rhBMP-2) from demineralized dentin matrix
In Woong UM ; Jeong Kui KU ; Bu Kyu LEE ; Pil Young YUN ; Jeong Keun LEE ; Jeong Hun NAM
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2019;45(3):123-128
Demineralized dentin matrix (DDM) has been used as a recombinant human bone morphogenetic protein-2 (rhBMP-2) carrier in many clinical trials. To optimize the clinical safety and efficacy of rhBMP-2 with DDM, efforts have been made to improve the delivery of rhBMP-2 by 1) lowering the administered dose, 2) localizing the protein, and 3) prolonging its retention time at the action site as well as the bone forming capacity of the carrier itself. The release profile of rhBMP-2 that is associated with endogenous BMP in dentin has been postulated according to the type of incorporation, which is attributed to the loosened interfibrillar space and nanoporous dentinal tubule pores. Physically adsorbed and modified, physically entrapped rhBMP-2 is sequentially released from the DDM surface during the early stage of implantation. As DDM degradation progresses, the loosened interfibrillar space and enlarged dentinal tubules release the entrapped rhBMP-2. Finally, the endogenous BMP in dentin is released with osteoclastic dentin resorption. According to the postulated release profile, DDM can therefore be used in a controlled manner as a sequential delivery scaffold for rhBMP-2, thus sustaining the rhBMP-2 concentration for a prolonged period due to localization. In addition, we attempted to determine how to lower the rhBMP-2 concentration to 0.2 mg/mL, which is lower than the approved 1.5 mg/mL.
Bone Morphogenetic Proteins
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Collagen
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Dentin
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Humans
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Osteoclasts
4.Progress and prospect in the research of bone morphogenetic protein heterodimer.
Yuanna ZHENG ; Linhong WANG ; Zhiyuan GU
Journal of Biomedical Engineering 2010;27(6):1428-1432
Bone morphogenetic protein (BMP) homodimers are of significant osteoinductivity. However, their clinical application is limited because of high effective dosage. Recently, BMP heterodimers are reported to address the issue. This is a review of the researches on BMP heterodimers, including existent evidences, types and synthetic methods, biological activities in comparison to BMP homodimers and possible mechanisms, further research direction and future expectations.
Animals
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Biopolymers
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Bone Morphogenetic Protein 2
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Bone Morphogenetic Protein 7
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Bone Morphogenetic Proteins
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genetics
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pharmacology
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Humans
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Protein Multimerization
5.The role of bone morphogenetic protein signaling pathway in tooth root development.
Cang-Wei LIU ; Yi-Jun ZHOU ; Guang-Xing YAN ; Ce SHI ; Xue ZHANG ; Yue HU ; Xin-Qing HAO ; Huan ZHAO ; Hong-Chen SUN
West China Journal of Stomatology 2018;36(5):559-563
The bone morphogenetic protein (BMP) family is an important factor in the regulation of cell ular life activities and in the development of almost all tissues. BMP-mediated signaling plays an important role in tooth root development, which is a part of tooth development. Epithelial and mesenchymal interactions are involved in tooth root development, but the BMP signaling pathway has a different effect on tooth root development in epithelial and mesenchymal. This review summarizes the advances of BMP signaling in tooth root development.
Bone Morphogenetic Protein 2
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Bone Morphogenetic Protein 7
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Bone Morphogenetic Proteins
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physiology
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Odontogenesis
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Signal Transduction
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Tooth
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Tooth Root
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growth & development
6.Evaluation of bone formation by recombinant human BMP-2 and rapid prototype titanium cap in rabbit calvaria using micro computed tomography.
Man Seung HAN ; Seunggon JUNG ; Bang Sin KIM ; Ji Woong YANG ; Min Suk KOOK ; Hong Ju PARK ; Sun Youl RYU ; Hee Kyun OH
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2010;36(6):466-472
INTRODUCTION: This study examined the effect of recombinant human bone morphogenetic protein (rhBMP)-2 and beta-tricalcium phosphate (beta-TCP) on new bone formation in a rabbit calvarium using a rapid prototype titanium cap (RP Ti cap). MATERIALS AND METHODS: Eight New Zealand white rabbits were used in this study. Hemispherical RP Ti caps (10 mm in diameter) were implanted subperiosteally on the rabbit calvaria. beta-TCP was filled in the RP Ti cap in the control group, and rhBMP-2 soaked beta-TCP was used in experimental group. The rabbits were sacrificed 2 and 4 weeks after the operation. The volume and pattern of newly formed bone was analyzed by micro computed tomography (CT). RESULTS: Macroscopically, there were no abnormal findings in any of the animals. The micro CT images revealed new bone from the calvaria that expanded gradually toward the top of the titanium cap, particularly along the inner surface of the titanium cap in the experimental group at 4 weeks after grafting. There was no significant difference in new bone volume ratio between the control and experimental groups at 2 weeks after grafting. There was a statistically significant difference in the new bone volume ratio between the experimental (14.1+/-1.8 %) and control (7.2+/-1.5 %) groups at 4 weeks after grafting (P<0.01). CONCLUSION: The RP Ti cap can effectively guide new bone formation and rhBMP-2 can induce the new bone formation.
Animals
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Bone Morphogenetic Protein 2
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Bone Morphogenetic Proteins
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Calcium Phosphates
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Humans
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Osteogenesis
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Rabbits
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Skull
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Titanium
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Transplants
7.Vertebral osteomyelitis with profound neurologic deficit: Successful treatment with rhBMP-2 and titanium cage device.
Sembrano Jonathan N. ; Yson Sharon C. ; Polly David W.
Acta Medica Philippina 2012;46(2):69-73
The efficacy of bone morphogenetic proteins (BMP) in infection has not yet been established. Since fusion is a necessary aim in the treatment of vertebral osteomyelitis with spinal instability, BMP may be a helpful adjunct in the surgical treatment of these cases. We present a case of vertebral osteomyelitis associated with neurologic deficits, treated with decompression and fusion using recombinant human bone morphogenetic protein-2 (rhBMP-2) and titanium cage device. Eradication of infection, recovery of neurologic deficits, spinal stabilization and solid fusion were achieved and maintained at 5 years follow-up.
Human ; Female ; Aged ; Recombinant Human Bone Morphogenetic Protein-2 ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins ; Transforming Growth Factor Beta ; Recombinant Proteins ; Osteomyelitis
8.Effect of composite of bone morphogenetic protein and plaster of paris on healing of bone defect in the rat tibia.
Goo Hyun BEAK ; Sang Hoon LEE ; Han Koo LEE
The Journal of the Korean Orthopaedic Association 1993;28(7):2540-2549
No abstract available.
Animals
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Bone Morphogenetic Proteins*
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Calcium Sulfate*
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Rats*
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Tibia*
9.A Study on Freeze
The Journal of the Korean Orthopaedic Association 1988;23(3):929-935
I had an opportunity to visit U.S. Naval Tissue Bank and observed tissue procurement and preservation by freeze-drying method and its clinical application while I stayed in the Naval Hospital, Bethesda in 1954. The freeze-dried tissues, especially bone graft, has shown excellent bone repair experimentally and clinically. Recently the mechanisms of osteoinduction have observed by many researchers and isolated the substance, bone morphogenetic protein, and clarified the interaction between BMP and the determined or inducible osteoprogenitor cells.
Bone Morphogenetic Proteins
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Methods
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Tissue and Organ Procurement
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Tissue Banks
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Transplants
10.Development of bone regenerating material using bone morphogenetic protein(rhBMP-2) and bioresorbable polymer
Jong Ho LEE ; Jong Won KIM ; Kang Min AHN ; Kack Kyun KIM ; Zang Hee LEE
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 1999;21(4):325-331
bone regenerating capacity and histologic response of bioresorbable matrix-type implant, which was made with Poly(lactide-co-glycolide)(PLGA) and bone apatite for the carrier of bone morphogenetic protein(BMP). The critical size defect of 8 mm in diameter was created at the calvaria of SD rats(n=18), and repaired with polymer implant with 15 microgram of rhBMP-2(n=9) or without it(n=9). At 2 weeks, 1 month and 3 months after implantation, the animals were sacrificed(3 animals at every interval and group) and histologically evaluated. The calvarial defect which was repaired with polymer with BMP healed with newly formed bone about 70% of total defect. But that without BMP showed only 0 to under 30% bony healing. Inflammatory response was absent in both group through the experimental period, but there's marked foreign body giant response though it was a little less significant in polymer with BMP group. As the polymer was resorbed, the space was infiltrated and replaced by fibrovascular tissue, not by bone. In conclusion, our formulation of bioresorbable matrix implant loaded with bone morphogenetic protein works good as a bone regenerating material. However, it is mandatory to devise our system to have better osteoinductive and osteoconductive property, and less multinucleated giant cell response.]]>
Animals
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Bone Morphogenetic Proteins
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Foreign Bodies
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Giant Cells
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Polymers
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Skull