1.Some heamatological features of the bone marrow failure
Journal of Practical Medicine 2000;385(8):25-27
We had drawn out some following remarks from the our studied group of patients with bone marrow failure; - There are 89.29% patients with bone marrow failure in three blood cell lineages; and 35.71% of the patients is servere aplastic anemia. - 14.29% patients with bone marrow failure were finished in the diagnosis of acute leukemia(M1= 50%, M2= 50%). - The persentages of the patients with bone marrow failure died from infection (37.5%) and hemorrhage (50.0%) are still high. Almost of the patients were died in the stage from 24 months to 48 months after having the diagnosis.
Bone Marrow Diseases
;
diagnosis
;
bone marrow
2.Clinical and epidemiological features of bone marrow failure
Journal of Practical Medicine 2000;383(6):12-14
From 26 patients with bone marrow failure, we had drawn some following remarks:- Over 50% of the patients is in the ages from 61 to 75 years old. (youngest: 42: oldest: 82 years old).- There were 38.46% of the patients that were used to contact with some causes of AA in their history particalarly 11.54%- using cloramphenicol; and 7.69% used to live in the area with American orange toxicant. - 100% of the patient with anemia; 15.36% with anemia + hemorrhage; then anemia + infection (7.69%) and anemia + hemorrahage + infection(7.69%).
Bone Marrow Diseases
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diagnosis
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Epidemiologic Studies
3.Bone Marrow Examination: Adventures in Diagnostic Hematology.
Yonsei Medical Journal 1986;27(2):100-105
4.Retroperitoneal Hemorrhage after Bone Marrow Aspiration and Biopsy in an Essential Thrombocythemia Patient.
Ik Ju JUNG ; Seung Taek LIM ; Yeon Seok CHOI ; Tae Soo JANG ; Sun Hee OH ; Hyung Bin YUK ; Do Yeun CHO
Korean Journal of Medicine 2015;88(5):598-601
Bone marrow examination is useful in the diagnosis and staging of hematologic disease. This procedure is generally considered safe; however, there are several adverse events associated with bone marrow biopsy. The most frequent and serious adverse event is hemorrhage. Risk factors include coagulopathy, myeloproliferative disorders, and anticoagulant or antiplatelet medications. Most hemorrhage is local hematoma; however, infrequently retroperitoneal hemorrhage occurs. In the case of massive hemorrhage, operation or angiographic embolization may be required. We report on a case of retroperitoneal hemorrhage after bone marrow aspiration and biopsy in an essential thrombocythemia patient.
Biopsy*
;
Bone Marrow Examination
;
Bone Marrow*
;
Diagnosis
;
Hematologic Diseases
;
Hematoma
;
Hemorrhage*
;
Humans
;
Methods
;
Myeloproliferative Disorders
;
Risk Factors
;
Thrombocythemia, Essential*
5.Persistent Anemia in a Patient with Diffuse Large B Cell Lymphoma: Pure Red Cell Aplasia Associated with Latent Epstein-Barr Virus Infection in Bone Marrow.
Hwa Jung SUNG ; Seok Jin KIM ; Ji Hye LEE ; Goeun LEE ; Kyung A LEE ; Chul Won CHOI ; Byung Soo KIM ; Jun Suk KIM
Journal of Korean Medical Science 2007;22(Suppl):S167-S170
We report a case of pure red cell aplasia (PRCA), which was initially suspected as a result of bone marrow involvement of diffuse large B cell lymphoma. Persistent anemia without an obvious cause was observed in a 47-yr-old man diagnosed with relapsed diffuse large B cell lymphoma. The bone marrow study showed only erythroid hypoplasia without the evidence of bone marrow involvement with lymphoma cells, thus PRCA was suggested. However, parvovirus infection was excluded as a potential cause of PRCA because of negative IgM anti-parvovirus B19 antibody and negative parvovirus PCR in the serum. Latent Epstein-Barr virus (EBV) infection of bone marrow was suggested by in situ hybridization with EBV-encoded small RNA (EBER) that showed a strong positive expression in bone marrow cells. Thus, PRCA was thought to be associated with latent EBV infection in bone marrow cells. Although the finding of unexplained anemia is a possible predictor of bone marrow involvement with lymphoma cells, PRCA as a result of a viral infection including EBV should be considered in lymphoma patients. This is the first report of the occurrence of PRCA associated with latent EBV infection in a patient with non-Hodgkin's lymphoma.
Adult
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Bone Marrow/pathology
;
Bone Marrow Diseases/*complications/diagnosis/pathology
;
Bone Marrow Neoplasms/pathology
;
Diagnosis, Differential
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Epstein-Barr Virus Infections/*complications/diagnosis
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Humans
;
Lymphoma, Large B-Cell, Diffuse/*complications/pathology
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Male
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Red-Cell Aplasia, Pure/diagnosis/*etiology
6.Nuclear Medicine Imaging Diagnosis in Infectious Bone Diseases.
Nuclear Medicine and Molecular Imaging 2006;40(4):193-199
Infectious and inflammatory bone diseases include a wide range of disease process, depending on the patient's age, location of infection, various causative organisms, duration from symtom onset, accompanied fracture or prior surgery, prosthesis insertion, and underlying systemic disease such as diabetes, etc. Bone infection may induce massive destruction of bones and joints, results in functional reduction and disability. The key to successful management is early diagnosis and proper treatment. Various radionuclide imaging methods including three phase bone scan, Ga-67 scan, WBC scan, and combined imaging techniques such as bone/Ga-67 scan, WBC/bone marrow scan add complementary role to the radiologic imaging modalities including plain radiography, CT and MRI. F-18 FDG PET imaging also has recently been introduced in diagnosis of infected prosthesis and chronic active osteomyelitis. Selection of proper nuclear medicine imaging method will improve the diagnostic accuracy of infectious and inflammatory bone diseases, based on understading of pathogenesis and radiologic imaging findings.
Bone Diseases
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Bone Diseases, Infectious*
;
Bone Marrow
;
Diagnosis*
;
Early Diagnosis
;
Joints
;
Magnetic Resonance Imaging
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Nuclear Medicine*
;
Osteomyelitis
;
Prostheses and Implants
;
Radiography
;
Radionuclide Imaging
7.Two Cases of Myelofibrosis Mimicking Malignant Lymphoma in Computed Tomography of Abdomen: A Case of Autoimmune Myelofibrosis associated with Systemic Lupus Erythematosus Showing Extensive Lymphadenopathy and A Case of Chronic Idiopathic Myelofibrosis wit.
Kyung A LEE ; Goeun LEE ; Sun Hyoung KIM ; Sookwon RYU ; Jin Kyung LEE ; Yunjung CHO ; Young Kee KIM
The Korean Journal of Laboratory Medicine 2004;24(6):352-357
Myelofibrosis results from stimulation of bone marrow stromal fibroblasts by fibrogenic cytokines elaborated by neoplastic or reactive cells in the marrow. Chronic idiopathic myelofibrosis should be differentiated from secondary myelofibrosis resulting from bone marrow involvement of malignant lymphoma because these diseases have different therapeutic strategies. Myelofibrosis in systemic lupus erythematosus is an uncommon but well-recognized complication, and identifying an autoimmune myelofibrosis is important in diagnosing this benign cause of myelofibrosis. We report two cases of myelofibrosis presenting the clinical and radiologic findings that mimicked malignant lymphoma -a case of autoimmune myelofibrosis associated with systemic lupus erythematosus showing extensive lymphadenopathy and a case of chronic idiopathic myelofibrosis with focal intrasplenic extramedullary hematopoiesis- and discuss the importance of the clinical information and radiologic findings for the pathologic diagnosis of myelofibrosis.
Abdomen*
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Bone Marrow
;
Cytokines
;
Diagnosis
;
Fibroblasts
;
Hematopoiesis, Extramedullary*
;
Lupus Erythematosus, Systemic*
;
Lymphatic Diseases*
;
Lymphoma*
;
Primary Myelofibrosis*
8.Evaluation for usefulness of bone marrow study in fever of unknown origin.
Yeong Sic KIM ; Woo In LEE ; Jin Tae SUH ; Hee Joo LEE
Korean Journal of Clinical Pathology 1999;19(6):598-601
BACKGROUND: As the new diagnostic methods for evaluation of fever of unknown origin (FUO) have been developed, the clinical spectrum of FUO has been changed. Although bone marrow study was commonly used in the evaluation of FUO, it's value has not been established. We evaluated the value of bone marrow study for FUO patients. MATERIAL AND METHODS: The 53 patients with FUO who have been performed bone marrow study from 1991 to 1998 were studied, retrospectively. Radiologic, serologic, hematologic, biopsy of tissue, chemistry, molecular and microbiologic review were included in this study. RESULTS: The etiology of FUO was identified in 31(58.5%) of the 53 patients through bone marrow examination. Of 53 patients, bacterial infection accounts for 12(22.6%); neoplasm 10(18.9%); SLE 3(5.7%); aplastic anemia 2(3.8%); drug induced 2(3.8%); necrotizing lymphadenitis 1(1.8%); hereditary spherocytosis 1(1.8%). Bone marrow examination as confirmative diagnostic method was valuable in 12(38.7%) of 31 patients who's etiology was identified. Of 53 patients, 22 persons (41.5%) showed no abnormal findings in marrow. CONCLUSION: Bone marrow study for FUO was very useful to diagnose hematologic diseases and miliary tuberculosis, but it was considered to be a less useful method for the initial diagnosis for the other diseases.
Anemia, Aplastic
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Bacterial Infections
;
Biopsy
;
Bone Marrow Examination
;
Bone Marrow*
;
Chemistry
;
Diagnosis
;
Fever of Unknown Origin*
;
Fever*
;
Hematologic Diseases
;
Humans
;
Lymphadenitis
;
Retrospective Studies
;
Tuberculosis, Miliary
9.Kostmann's Disease: A Case Report.
Cheol Gyu YOON ; Jin Gyu JANG ; Jong Beom SIN ; Soon Yong LEE
Korean Journal of Pediatric Hematology-Oncology 1999;6(1):136-140
Kostmann's disease is a rare hematologic disease entity which is characterized by persistent neutropenia and recurrent bacterial infections since early in infancy. The authors experienced a 2-month-old female infant with disseminated bacterial skin infection since 3 weeks of age and persistent neutropenia. Diagnosis was made by neutropenia in the peripheral blood, maturation arrest of myeloid hemopoiesis at myelocyte stage in the finding of bone marrow aspiration and improving response of neutropenia with G-CSF administration. She had experienced 4 episodes of sepsis and one episode of acute otitis externa during follow-up until 14 months of age.
Bacterial Infections
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Bone Marrow
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Bone Marrow Transplantation
;
Diagnosis
;
Female
;
Follow-Up Studies
;
Granulocyte Colony-Stimulating Factor
;
Granulocyte Precursor Cells
;
Hematologic Diseases
;
Humans
;
Infant
;
Neutropenia
;
Otitis Externa
;
Sepsis
;
Skin
10.Temporomandibular Joint Disorder from Skull Base Osteomyelitis: A Case Report
Byoung Gil RYU ; Hyun Joong YOON ; Sang Hwa LEE
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2012;34(6):484-487
bone marrow of the temporal bone, sphenoid bone, occipital bone. It occurs typically chronic ear canal infections by malignant otitis externa, but some of atypical osteomyelitis have been reported. It most commonly presents old diabetic patients, and have high morbidity and mortality rate if diagnosis and treatment are delayed. However with respect to pain or dysfunction, it appeared similar to the initial symptoms of temporomandibular joint disorder. So frequently, definitive diagnosis is tend to delayed. We have clinical experience that a patient who presented with symptom similar to temporomandibular disorder, and differential diagnosised by skull base osteomyelitis. We will report this case with literature review.]]>
Bone Marrow
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Diagnosis, Differential
;
Ear Canal
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Humans
;
Occipital Bone
;
Osteomyelitis
;
Otitis Externa
;
Rare Diseases
;
Skull
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Skull Base
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Sphenoid Bone
;
Temporal Bone
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Temporomandibular Joint
;
Temporomandibular Joint Disorders