The study was carried out in 65 aplastic anemia patients admitted into B¹ch Mai hospital during the period 1995-1999 on the issues of immunological characteristics. The results can be summarized as follows: The count of lymphocytes and the majority of sub-groups of lymphocytes were decreased compared with the control group (p<0.05 - 0.01). The TCD4/TCD8 ratio is decrease compared with the control group. The level of IgG in plasma increased. In the bone marrow, the count of subgroup of lymphocytes decreased compared with the control group. Comparing between peripheral blood and bone marrow, it can be seen that the percentage of T lymphocytes and its sub-groups decreased significantly. The change of the percentage of B lymphocytes however, it is not significant.
Bone Marrow Diseases ; Etiology

To explore the theory of "Shaoyang Meridians being in charge of the bone" in Huangdi's Internal Classic, which has been buried for long time. With citation of Huangdi's Internal Classic and exposition of famous experts, speculate on the contents and meanings systematically. Results indicate that the theory of "Shaoyang Meridians being in charge of the bone" possibly first in the world recognizes osteoporosis being a general bony disease, and articulates that the Foot-Shaoyang Meradians can modulate bony strength under physiological and pathological conditions, and treat osteoporosis which mainly manifests as ostealgia and easy fracture.
Bone Density ; Bone Diseases ; etiology ; therapy ; Humans ; Medicine, Chinese Traditional ; Meridians ; Osteoporosis ; etiology

Adult ; Bone Diseases, Metabolic ; etiology ; Female ; Fractures, Spontaneous ; etiology ; Humans ; Liver Diseases, Alcoholic ; complications

There is much confusion in orthopedic literature regarding the nature and significance of the so-called acetabular labrum in congenital dislocation of the hip. This experiment describes an animal model in which the relationship between eversion of the acetabular labrum and acetabular dysplasia with degeneration of the articular cartilage was studied. The acetabulum gradually become shallower and more vertically oriented and the femoral head gradually subluxed, but never dislocated. The radiographic appearance of the hip dysplasia was very similar to that seen in human beings. The animals remained asymptomatic without clinically visible signs of hip abnormality throughout the study. It was clearly demonstrated that there was substantial amounts of degenerative change in the articular cartilages of the subluxed hip with no evidence of degenerative change radiologically. It could be concluded that excision of the acetabular labrum should be avoided during open reduction of congenital dislocation of the hip.
Acetabulum/pathology* ; Animal ; Bone Diseases, Developmental/etiology* ; Dogs ; Hip Dislocation/complications* ; Osteoarthritis/etiology*

Bone Diseases ; complications ; Child ; Facial Paralysis ; etiology ; Female ; Humans ; Hyperplasia ; Temporal Bone ; pathology

Multiple myeloma (MM) is a B cell malignancy characterized by enhanced bone loss that commonly associated with diffuse osteopenia, focal lytic lesions, pathologic fractures, and bone pain. The key mechanism of bone damage in myeloma is the abnormal regulation in bone metastasis, with increased osteoclast function and decreased osteoblast activity. This article reviewed the factors implicated, such as receptor activator of nuclear factor-kappaB (RANK), receptor activator of nuclear factor-kappaB ligand (RANKL), osteoprotegerin (OPG), macrophage inflammatory protein-1alpha (MIP-1alpha), SDF-1 and Wnt pathway. Further understanding of the regulation system of bone homeostasis helps to offer possible targets for future therapy.
Bone Diseases ; etiology ; Bone and Bones ; pathology ; Humans ; Multiple Myeloma ; complications ; pathology ; Osteoblasts ; pathology ; Osteoclasts ; pathology

To compare the bone mineral density (BMD) and determine the frequency of osteoporosis in mild and advanced ankylosing spondylitis (AS) cases. Seventy three patients with AS were enrolled in this study. The BMD was analyzed at the lumbar spine and hip by dual energy X-ray absorptiometry. The patients were diagnosed as being "normal, osteopenia, or osteoporosis" according to the WHO classification. Using the BASRI-lumbar and BASRI-hip scores, the patients were grouped in mild and advanced AS categories. The mean BMD in the lumbar spine and hip of patients with mild and advanced AS was similar (p > 0.05). While 61.6% of the patients were found to have osteopenia or osteoporosis in the lumbar spine, 46.6% had osteopenia or osteoporosis in the total hip. Of the patients with advanced AS 54.3% had osteopenia or osteoporosis in the lumbar spine, 75% in the total hip. Of the patients with mild AS patients had 68.4% osteopenia or osteoporosis in the lumbar spine, and 42.3% in the total hip. The osteopenia or osteoporosis frequency of the mild and advanced cases of AS in the lumbar spine was similar (p > 0.05). In the advanced AS patients, osteopenia or osteoporosis frequency was significantly higher in the total hip than in the mild AS patients (p < 0.05). In conclusion, there was evidence of osteoporosis in both the advanced AS and mild AS patients. The reason why the anteroposterior lumbar DXA results in the advanced AS patients were similar to the mild ones may be due to the existence of syndesmophytes and ligament calcification. In these cases, it is more convenient to use a hip DXA for assessing the extent of osteoporosis.
Adult ; *Bone Density ; Bone Diseases, Metabolic/etiology ; Disease Progression ; Female ; Human ; Male ; Middle Aged ; Osteoporosis/etiology ; Spondylitis, Ankylosing/complications/*physiopathology

UNLABELLEDTo explore the occurrence patterns of pulmonary complications at different stages in haploidentical bone marrow transplantation, a series of clinical data as the onset time, etiology, management choices and prognosis in 18 patients with pulmonary disorders were summarized. The results showed that in 18 out of 70 patients after bone marrow transplantation occurred pulmonary complications which included pneumonia affected by bacteria (7 cases), fungus (5 cases) and cytomegalovirus (CMV, 4 cases), bronchiolitis obliterans organizing pneumonia (BOOP, 1 case), and idiopathic pneumonia syndrome (1 case), out of which 8 cases died. Fungal and CMV pneumonia occurred predominantly 2 to 3 months after transplantation, whereas bacterial pneumonia was observed in the duration of 3 to 12 months and 4 cases of them suffered from secondary fungal infections during treatment. BOOP and idiopathic pneumonia syndrome were diagnosed 12 months and 50 days after transplantation respectively.

IN CONCLUSIONpulmonary complications were commonly seen in haploidentcal bone marrow transplantation, and fungal pneumonia might be the main cause that needs intensive management.

Adult ; Bone Marrow Transplantation ; adverse effects ; Cryptogenic Organizing Pneumonia ; etiology ; Cytomegalovirus Infections ; etiology ; Female ; Haplotypes ; Humans ; Lung Diseases ; etiology ; Male

Bone Diseases, Metabolic ; diagnosis ; etiology ; therapy ; Chronic Disease ; Humans ; Liver Diseases ; complications ; diagnosis ; therapy

Seventy-two cases of benign fibro-osseous lesions of the jaws were reassessed, and a modified classification is proposed that may be helpful in their understanding and management. The anatomical distribution of these cases is described and compared to previously reported cases. The histogenesis of each particular lesion is also discussed. Correlative analysis of histopathologic and oral radiographic features is essential for definitive diagnosis.
Adolescent ; Adult ; Aged ; Child ; Female ; Fibrous Dysplasia of Bone/classification/*diagnosis/etiology ; Human ; Jaw Diseases/classification/*diagnosis/etiology ; Male ; Middle Age