No abstract available.
Bone Diseases ; Bone Marrow ; Bone Regeneration ; Necrosis

Craniodiaphyseal dysplasia is a rare hereditary bone dysplasia characterized by craniofacial hyperostosis anddiaphyseal dysplatic changes. We reviewed the clinical, radiologic and laboratory features of one such case.
Bone Diseases, Developmental ; Hyperostosis

From 1990 to 2000, 513 cases of aplastic anemia were diagnosed and treated in Blood transfusion and Hematology Centre of Ho Chi Minh city, composing of 144 children and 369 adults with 279 males and 234 females. By bone marrow aspiration and biopsy, we diagnosed these cases as follow: aplastic anemia 449 cases (87.5%), hypocellularity of bone marrow: 45 (8.8%), one lignea hypocellularity of bone marrow: 19 (3.7%). From these cases, we have found that: - ’s difficult to point out accurately the cause of aplastic anemia and this is still the question for many studies in future. - All the patient was treated mainly blood transfusion, corticoid and androgen (77.5%) with complete and partial response was 25.5%. Besides, 32 cases were treated with corticoid + Sandimum given better results with complete response (32.7%).
Bone Marrow Diseases ; therapeutics

The study was carried out in 65 aplastic anemia patients admitted into B¹ch Mai hospital during the period 1995-1999 on the issues of immunological characteristics. The results can be summarized as follows: The count of lymphocytes and the majority of sub-groups of lymphocytes were decreased compared with the control group (p<0.05 - 0.01). The TCD4/TCD8 ratio is decrease compared with the control group. The level of IgG in plasma increased. In the bone marrow, the count of subgroup of lymphocytes decreased compared with the control group. Comparing between peripheral blood and bone marrow, it can be seen that the percentage of T lymphocytes and its sub-groups decreased significantly. The change of the percentage of B lymphocytes however, it is not significant.
Bone Marrow Diseases ; Etiology

Study was conducted over 102 workers working directly at 3 workshops of agriculture machine by questionnaire and by measuring parameters at working environment to assess the impacts of working positions and working conditions to ache of musco-skeletal of workers. Results: the temperature exceed the allowed limits from 2.8 to 5.3 0C, wind speed at one site not to meet the standard, the noise exceed the allowed limits from 1 to 11dBA. 49.5% of workers said that the illumination power at workshops was insufficiency. Dust levels exceed the allowed limits twofold. The number of accident at work and the cases of occupational disease are significantly increasing every year. The results suggested that it must improve work condition as well as health care for worker of the agriculture machine manufactures.
Muscular Diseases ; Bone and Bones

Delayed presentation of Developmental Dysplasia of Hip (DDH) comes with challenges in treatment as well as high surgical cost. Therefore the objective of this study is to quantify the economic impact of management of late presentation of DDH during a last 3-year period. We conducted a retrospective study with analysis of DDH cases managed between years 2012 to 2014. Early and late presentations of DDH were identified and cost management for both was estimated. Out of twenty-four DDH cases, thirteen cases fulfilled the inclusion criteria. All were female with majority of them presenting with unilateral DDH predominantly of the left hip. Most patients presented after age of six months and the principal complaint was abnormal or limping gait. The grand total cost for managing DDH during the three years period was USD 12,385.51, with 86% of the amount having been used to manage late presentation of DDH that was mostly contributed by the cost of surgery. We concluded that delayed presentation of DDH contributes heavily to high national expenditure. Early detection of DDH cases with systematic neonatal screening may help to minimize the incidence of the late presenting DDH and subsequently reduce the economic burden to the government.
Bone Diseases, Developmental

We had drawn out some following remarks from the our studied group of patients with bone marrow failure; - There are 89.29% patients with bone marrow failure in three blood cell lineages; and 35.71% of the patients is servere aplastic anemia. - 14.29% patients with bone marrow failure were finished in the diagnosis of acute leukemia(M1= 50%, M2= 50%). - The persentages of the patients with bone marrow failure died from infection (37.5%) and hemorrhage (50.0%) are still high. Almost of the patients were died in the stage from 24 months to 48 months after having the diagnosis.
Bone Marrow Diseases ; diagnosis ; bone marrow

MR imaging may help detect the bone marrow edema, which is seen as increased signal intensity with poorly defined margins on STIR images. Unfortunately, STIR sequence is not available in our Magnetom 1.0 Tesla menu. Based on old IR sequence in this MR unit, we have tried to make a new STIR sequence. This sequence is proved on image quality in bone contusion and early inflammation diagnosis.
Bone Diseases ; diagnosis ; Early Diagnosis ; Bone and Bones

There were 39 aplastic anemia patients with immunopathology, who was treated by immunosuppresion such as: Spleenectomy, thymus transplantation using cyclosporine A. The results show that: immunosuppression has successful rate of 50-60% in aplastic anemia after internal treatment was not effectiveness.
Bone Marrow Diseases ; Immunosuppression ; Therapeutics

Background: Vitamin D deficiency occurs in 10% to 36% of children with cholestasis. The relationship between serum vitamin D levels, severity of liver disease and bone abnormalities in children has not been extensively investigated.

Objective: To determine serum vitamin D levels and its association with liver disease severity and presence of radiographic rickets in children with cholestasis.

Methods: Children aged 0-10 years with cholestasis underwent serum 25-hydroxyvitamin D levels (25-[OH]D) determination, radiographs of wrists and knees and liver function tests. Liver disease severity was evaluated using the Child-Pugh score. Radiographs were assessed using Thacher Rickets Severity Score. Data were analyzed using odds ratio and Spearman's correlation coefficient.

Results: We included 51 children [Mean (SD) age: 5 (6) months, 63% are males], mostly with biliary atresia (51%). Forty-seven (92%) had serum 25-(OH)D deficiency and four (8%) had insufficiency. Radiologic bone abnormalities were observed in 22 (43%) cases; specifically, rickets in 16 (31%). No association was observed with vitamin D levels and liver disease severity (OR 1.27, 95% CI 0.12-13.31) nor with rickets score (OR 0.07, 95% CI 0.004-1.37).

Conclusion: Majority of the children with cholestasis had vitamin D deficiency, with a third having radiographic findings of rickets. Serum vitamin D levels were not associated with liver disease severity or with rickets score.

Key Words: Vitamin D, rickets, cholestasis, bone disease, bone abnormalities