A study on 116 patients more than 50 years in a private clinic in Hue City has shown that 39 patients had symptoms of osseous demineralization in the film of thoraco-liunbal spine. The rat of osseous demineralization increased with age, especially in women. The common complications of the osseous demineralization were long bone fracture and spinal flat.
Bone Demineralization, Pathologic ; aged

Bone Demineralization, Pathologic ; prevention & control ; Dental Caries ; prevention & control ; therapy ; Dental Restoration, Permanent ; Education, Dental ; Gingivitis ; prevention & control ; Humans ; Orthodontics, Corrective ; Preventive Dentistry ; education

OBJECTIVETo study the characteristics of mandible and condyle in Dmp1 gene knockout mice, and to investigate the role of Dmp1 in the osteogenesis and mineralization of bone and cartilage.

METHODSDmp1-/-mice were executed at birth, 2 weeks, 2 months, 3 months and 5 months, and the mandible was taken out for physical, radiography, transmission electron microscopic, and histological examination. The difference between Dmp1 knockout mouse (ko) and wild type mouse (wt) in bone development, bone densitometry and histology were compared.

RESULTSThere were obvious changes in the mandible and condyle of Dmp1-/-mouse, such as incomplete ossification, low density, decreased volume and condyle cartilage degeneration.

CONCLUSIONSDmp1 is the key factor in the formation of growth plates and secondary ossification center, and plays an important role in the process of bone and cartilage formation and bone nodule remodeling. Dmp1 may be the candidate gene that controls the development of mandible and cartilage.

Animals ; Bone Demineralization, Pathologic ; genetics ; pathology ; Chondrogenesis ; genetics ; Extracellular Matrix Proteins ; genetics ; Gene Knockout Techniques ; Mandible ; pathology ; Mandibular Condyle ; pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Osteogenesis ; genetics