1.The STAT3 in Glucose Homeostasis.
Bon Jeong KU ; Su Hyeon PARK ; Koon Soon KIM ; Young Kun LIM ; Min Ho SHONG
Journal of Korean Society of Endocrinology 2004;19(3):274-280
No abstract avaiable.
Glucose*
;
Homeostasis*
2.Osteosarcoma, Arising after Resection and Irradiation of Synovioma: A Case Report
Jin Ho KIM ; Bon He KU ; Se Il SUK ; Moon Sik HAHN
The Journal of the Korean Orthopaedic Association 1970;5(3):112-114
1. A Case of osteosarcoma is reported which arose 8 years after synovima of the knee had been locally excised. The patient is a 51-year-old housewife who had received irradiation therapy upon her knee for 30 days post-operatively. Following irradiation, asymptomatic latent period lasted 8 years when mass appeared on the site, which was biopsied and diagnosed as osteosarcoma one year later. 2. This case generally suffices the McKennas criterias for irradiation-induced osteosarcoma, 3. It seems to be worthwhile to keep an eye upon the prognosis of this possible case of irradiation- induced osteosarcoma, which is largely reported to be very grave.
Humans
;
Knee
;
Middle Aged
;
Osteosarcoma
;
Prognosis
;
Sarcoma, Synovial
3.Subacute bacterial endarteritis associated with patent ductus arteriosus: A case report.
Dong Ky HAN ; Bi o CHOI ; Bon Il KU ; Yong Won PARK ; Hong Sup LEE ; Chang Ho KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(10):801-803
No abstract available.
Ductus Arteriosus, Patent*
;
Endarteritis*
4.Therapeutic Effects of Tazarotene on Psoriasis and Its Potential Action Mechanism in Inflammatory Angiogenesis.
Bon Seok KU ; Chae Wook LEE ; Ki Ho KIM
Korean Journal of Dermatology 2007;45(9):898-907
BACKGROUND: Psoriasis is characterized by chronic recurrent erythematous skin plaques that exhibit epidermal hyperplasia, inflammatory cell accumulation and abnormalities of the papillary dermal vasculature. Psoriatic skin lesions show enlargement and increased tortuosity of cutaneous microvessels without formation of new vessel sprouts, that is, inflammatory angiogenesis. Placental growth factor (PlGF) and Tie-2 were reported to be up-regulated during inflammatory angiogenesis. Tazarotene is the first receptor-selective retinoid and its effects include normalizing keratinocyte differentiation, reducing keratinocyte proliferation and reducing inflammation. OBJECTIVE: Our study evaluated the clinical efficacy of topical tazarotene treatment and clarified histological changes and possible action mechanisms of this agent in respect of inflammatory angiogenesis. METHODS: We selected patients with symmetric psoriatic lesions and applied 0.1% tazarotene gel (Tazorac(R)) versus calcitriol 3 microgram/g gel (Silkis(R)) twice a day for 12 weeks with a right-left comparison. We grouped the patients with treatment modalities. Clinical efficacy, which was measured by the overall lesional assessment (OLA) scores, was assessed at each visit in 2 week' intervals until treatment closed. Skin biopsies were performed before the treatment started and again at 4 weeks and 12 weeks after treatment. Immunohistochemistry of PlGF, Tie-2 and factor-VIII was performed to elucidate the anti-angiogenetic effect of tazarotene. RESULTS: At the completion of 12 weeks of treatment, the OLA score of tazarotene-treated lesions was more reduced than that of calcitriol-treated lesions combined with phototherapy, it was more effective. Several histologic features such as epidermal hyperplasia, inflammatory cell infiltration and vessel dilation/tortousity were improved with decreased PlGF and Tie-2 expressions. CONCLUSION: These results indicate that tazarotene is an effective topical agent for psoriasis by blocking inflammatory angiogenesis.
Biopsy
;
Calcitriol
;
Humans
;
Hyperplasia
;
Immunohistochemistry
;
Inflammation
;
Keratinocytes
;
Microvessels
;
Phototherapy
;
Psoriasis*
;
Skin
5.Two Cases of Acute Esotropia in Contralateral Thalamic Hemorrhage.
Jong Ho LEE ; Bon Dae KU ; Kye Hoon LEE ; Kyoung HEO
Journal of the Korean Neurological Association 1999;17(5):710-712
Monocular gaze palsies which result from a supranuclear cerebral lesion are rare clinical manifestations. The prefrontal cortico-oculomotor pathways travel across the thalamus and mesodiencephalic junction terminating directly in oculomotor complexes. These pathways exist bilaterally and the contralateral oculomotor bundle exerts an inhibitory influence upon the oculomotor neurons, particularly those related to the medial rectus muscle. The acute disinhibition of these neurons by a posterior thalamic lesion results in a sustained but transient discharge of the medial rectus and tonic activation. Impairment of monocular projections in the contralateral posterior thalamus could result in a tonic activation of the medial rectus, analogous to the conjugate gaze deviation observed with a frontal lobe lesion. We describe two patients with an acute onset of esotropia and contralateral supranuclear lesions - thalamic hemorrhages.
Esotropia*
;
Frontal Lobe
;
Hemorrhage*
;
Humans
;
Intracranial Hemorrhages
;
Neurons
;
Paralysis
;
Thalamus
6.Effects of Epidural Analgesia with Morphine and Bupivacaine on Bowel Motility after Gastrectomy.
Jong Seok LEE ; Yong Taek NAM ; Soon Ho NAM ; Bon Nyeo KU ; Min Woo GU
Korean Journal of Anesthesiology 1998;34(3):608-613
BACKGROUND: Postoperative ileus is a universal complication after major intraabdominal surgery. Choice of postoperative analgesia may affect the rate of functional recovery of bowel. Epidural analgesia with morphine and bupivacaine is a popular method for pain relief. However little is known about the effects of this regimen on bowel motility. METHODS: Forty patients undergoing partial or total gastrectomy were randomized into two groups. All groups received a standardized general inhalation anesthesia with enflurane. Control group received traditional intramuscular(IM) administration of meperidine for the postoperative analgesia. Experimental group received a bolus of epidural 0.5% bupivacaine 10 ml followed by continuous epidural infusion of 0.21% bupivacaine with 0.01% morphine, started at the end of operation with the basal infusion rate of 1 ml/hours, bolus 1 ml, and ldegrees Ckout interval 30 min during 48 hr. We compared the analgesic effect, side effects and restoration of bowel function(first passage of flatus and feces)between two groups. Postoperative pain was assessed using the 10 cm visual analog pain scale (0=no pain, 10=worst imaginable pain) at rest. Scores were taken at 1, 6 hours after operation and 7 AM, 6 PM of the 1st postoperative day and 7 AM of the 2nd postoperative day. RESULTS: Experimental group revealed superior analgesia(p<0.005) but had a greater incidence of nausea, pruritus and urinary retention. No significant difference was found in restoration of bowel function between two groups. CONCLUSION: There was no superior effect of epidural analgesia with morphine and bupivacaine on bowel motility after gastrectomy than the effect of traditional IM meperidine administration.
Analgesia
;
Analgesia, Epidural*
;
Anesthesia, Inhalation
;
Bupivacaine*
;
Enflurane
;
Flatulence
;
Gastrectomy*
;
Humans
;
Ileus
;
Incidence
;
Meperidine
;
Morphine*
;
Nausea
;
Pain Measurement
;
Pain, Postoperative
;
Pruritus
;
Urinary Retention
7.Angiomatoid Spitz Nevus.
Oh Eon KWON ; Bon Seok KU ; Yeong Kyu LEE ; Young Hun KIM ; Ki Ho KIM
Annals of Dermatology 2008;20(1):14-17
Spitz nevus is a variant of melanocytic nevus which is histopathologically defined as large spindle and/or epithelioid cells. Angiomatoid Spitz nevus is a rare histologic variant of desmoplastic Spitz nevus characterized by prominent vasculature. We present a case of angiomatoid Spitz nevus, celluar type, that has not been reported before. We provide another example to show the remarkable diversity of Spitz nevus.
Epithelioid Cells
;
Nevus, Epithelioid and Spindle Cell
;
Nevus, Pigmented
8.Clicnical experiences of arteriovenous fistula and associated operations for hemodialysis in 290 cases.
Young Chul YOON ; Bi O CHOI ; Bon Il KU ; Sang Jun OH ; Hong Sup LEE ; Haeng Il KO ; Chang Ho KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(10):761-768
No abstract available.
Arteriovenous Fistula*
;
Renal Dialysis*
9.A Case of Calcifying Aponeurotic Fibroma with Gait Disturbance.
Oh Eon KWON ; Bon Seok KU ; Dae Cheol KIM ; Chae Wook LEE ; Ki Ho KIM
Korean Journal of Dermatology 2006;44(1):71-74
Calvus, callus, plantar warts and piezogenic papules are well known to cause discomfort and disturbance of gait in ordinary physical and sports activities. Furthermore, calcifying aponeurotic fibroma, whose mass slowly grows on the palms and soles of children and young adults, leads to pain, disturbance of gait, and even to skeletal deformities. A 22-year-old woman noticed an elevated subcutaneous mass on the left plantar surface of her big toe, which was accompanied with pain, tenderness and gait disturbance. The histologic findings showed an ill-circumscribed fibroblastic proliferation with foci of calcification and chondroid differentiation. After total excision of the mass, the patient became free of the above symptoms and the lesion did not recur for 9 months.
Bony Callus
;
Child
;
Congenital Abnormalities
;
Female
;
Fibroblasts
;
Fibroma*
;
Gait*
;
Humans
;
Sports
;
Toes
;
Warts
;
Young Adult
10.Aortoesophageal Fistula after Prosthetic Patch Aortoplasty for Mycotic Aneurysm of the Descending Thoracic Aorta.
Hong Sup LEE ; Jae Wuk KIM ; Jae Il JUNG ; Chan Sik YUN ; Sun Hun LEE ; Young Chul YOON ; Bon Il KU ; Chang Ho KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2000;33(10):839-842
Aortoesophageal fistula is an uncommon and fatal complication after surgery of aortic aneurysm. A case of aortoesophageal fistula as a complication of synthetis patch aortoplasty for mycotic aneurysm of descending thoracic aorta is described. After 3 months since patch aortoplasty for mycotic aneurysm of descending thoracic aorta this patient visited the emergency room due to melena and hematemesis. After gastrofiberoscopy and computed tomography the patient was taken ot the operating room. The surgical intervention was performed in two steps. Median sternotomy and midline laparotomy were made. Hemashield's Dacron(16mm) bypass between ascending thoracic aorta and infra-renal abdominal aorta was established first. Through the posterolateral thoracotomy false aneurysm and previous Hemashield's Dacron patch of descending aorta were resected. The two ends of the aorta were sutured and esophageal fistula was repaired. The esophageal suture line and the stumps were covered with omental graft. Thirty months later the patient has had no difficulty referable to the aortic surgery.
Aneurysm, False
;
Aneurysm, Infected*
;
Aorta
;
Aorta, Abdominal
;
Aorta, Thoracic*
;
Aortic Aneurysm
;
Emergency Service, Hospital
;
Esophageal Fistula
;
Fistula*
;
Hematemesis
;
Humans
;
Laparotomy
;
Melena
;
Operating Rooms
;
Polyethylene Terephthalates
;
Sternotomy
;
Sutures
;
Thoracotomy
;
Transplants