The development of traditional Chinese medicine (TCM) diagnosis and treatment has undergone multiple paradigms, evolving from sporadic experiential practices to systematic approaches in syndrome differentiation and treatment and further integration of disease and syndrome frameworks. TCM is a vital component of the medical system, valued alongside Western medicine. Treatment based on syndrome differentiation embodies both personalized treatment and holistic approaches; however, the inconsistency and lack of stability in syndrome differentiation limit clinical efficacy. The existing integration of diseases and syndromes primarily relies on patchwork and embedded systems, where the full advantages of synergy between Chinese and Western medicine are not fully realized. Recently, driven by the development of diagnosis and treatment concepts and advances in analytical technology, Western medicine has been rapidly transforming from a traditional biological model to a precision medicine model. TCM faces a similar need to progress beyond traditional syndrome differentiation and disease-syndrome integration toward a more precise diagnosis and treatment paradigm. Unlike the micro-level precision trend of Western medicine, precision diagnosis and treatment in TCM is primarily reflected in data-driven applications that incorporate information at various levels, including precise syndrome differentiation, medication, disease management, and efficacy evaluation. The current priority is to accelerate the development of TCM precision diagnosis and treatment technology platforms and advance discipline construction in this area.

Objective To investigate the application value of metronidazole combined with cefuroxime sodium in the laparoscopic treatment of patients with acute non-simple appendicitis.Methods The subjects were 80 patients with acute non-simple appendicitis who underwent laparoscopic appendectomy from July 2020 to June 2023.Among them,41 patients with acute non-simple appendicitis who were treated with metronidazole combined with cefuroxime sodium for laparoscopic surgery were used as the observation group,and 39 patients with acute non-simple appendicitis who were treated with metronidazole combined with ceftriaxone sodium for laparoscopic surgery were used as the control group.The intraoperative situation,inflammation control before and after surgery,postoperative recovery status,and adverse reactions after medication were compared between the two groups.Results There were no statistically significant difference between the two groups in terms of periappendiceal abscess/peritonitis,surgical time,and intraoperative bleeding,the differences were not statistically significant(P>0.05);The inflammatory indexes of acute non-simple appendicitis in both groups gradually returned to normal after surgery,and the white blood cell count,procalcitonin(PCT)and C-reaction protein(CRP)levels in the observation group showed greater decrease than those in the control group,the differences were statistically significant(P<0.05)on the first day and the third day after surgery.The duration of analgesics use and hospital stay in the observation group were(1.8±1.2)and(3.5±0.7)d,respectively,which were significantly shorter than those of(2.7±1.4)and(4.6±0.4)d,the differences were statistically significant(P<0.05).The incidence of intra-abdominal infection in the observation group was 7.7%,which was significantly lower than that of 24.4%in the control group,the difference was statistically significant(P<0.05).The adverse reactions in the two groups were 4.9%and 7.7%,respectively,and the difference was not significant(P>0.05).Conclusion Metronidazole combined with cefuroxime sodium combined with laparoscopic appendectomy can significantly reduce the incidence of abdominal infection in patients with acute non-simple appendicitis,it has high safety.

OBJECTIVETo study the role of exercise in asthma management in children and formulate exercise prescriptions for asthmatic children.

METHODSA total of 112 asthmatic children aged 7-14 years were randomized into control group (n=56, with medications only) and exercise group (n=56, with medications and exercise prescription) for a trial lasting for 4 months. An asthma diary was used for all children to record the morning and evening peak expiratory flow (PEF), daytime and nighttime asthma symptom score, use of short-acting beta agonists, participation in physical activity, and exercise-induced asthma symptoms.

RESULTSOf the 112 children, 5 dropped out before the trial completion. From the 13th week, PEF variation in exercise group was significantly lowered compared to that in the control group (P<0.05). Upon the completion of the trial, the daytime and nighttime symptoms score and emergency medication score were all significantly lower in the exercise group than in the control group (P<0.05). No severe adverse events occurred in the children during the trial.

CONCLUSIONExercise for no less than 20 min, 3 days a week for 4 months is safe and beneficial for asthma control in children.

Adolescent ; Asthma ; prevention & control ; Child ; Exercise ; Female ; Humans ; Male

Objective To study the role of exercise in asthma management in children and formulate exercise prescriptions for asthmatic children. Methods A total of 112 asthmatic children aged 7-14 years were randomized into control group (n=56, with medications only) and exercise group (n=56, with medications and exercise prescription) for a trial lasting for 4 months. An asthma diary was used for all children to record the morning and evening peak expiratory flow (PEF), daytime and nighttime asthma symptom score, use of short-acting beta agonists, participation in physical activity, and exercise-induced asthma symptoms. Results Of the 112 children, 5 dropped out before the trial completion. From the 13th week, PEF variation in exercise group was significantly lowered compared to that in the control group (P<0.05). Upon the completion of the trial, the daytime and nighttime symptoms score and emergency medication score were all significantly lower in the exercise group than in the control group (P<0.05). No severe adverse events occurred in the children during the trial. Conclusion Exercise for no less than 20 min, 3 days a week for 4 months is safe and beneficial for asthma control in children.

Objective To study the role of exercise in asthma management in children and formulate exercise prescriptions for asthmatic children. Methods A total of 112 asthmatic children aged 7-14 years were randomized into control group (n=56, with medications only) and exercise group (n=56, with medications and exercise prescription) for a trial lasting for 4 months. An asthma diary was used for all children to record the morning and evening peak expiratory flow (PEF), daytime and nighttime asthma symptom score, use of short-acting beta agonists, participation in physical activity, and exercise-induced asthma symptoms. Results Of the 112 children, 5 dropped out before the trial completion. From the 13th week, PEF variation in exercise group was significantly lowered compared to that in the control group (P<0.05). Upon the completion of the trial, the daytime and nighttime symptoms score and emergency medication score were all significantly lower in the exercise group than in the control group (P<0.05). No severe adverse events occurred in the children during the trial. Conclusion Exercise for no less than 20 min, 3 days a week for 4 months is safe and beneficial for asthma control in children.

The STandards for Reporting Interventions in Clinical Trials Of Moxibustion (STRICTOM), in the form of a checklist and descriptions of checklist items, were designed to improve reporting of moxibustion trials, and thereby facilitating their interpretation and replication. The STRICTOM checklist included 7 items and 16 sub-items. These set out reporting guidelines for the moxibustion rationale, details of moxibustion, treatment regimen, other components of treatment, treatment provider background, control and comparator interventions, and precaution measures. In addition, there were descriptions of each item and examples of good reporting. It is intended that the STRICTOM can be used in conjunction with the main CONSORT Statement, extensions for nonpharmacologic treatment and pragmatic trials, and thereby raise the quality of reporting of clinical trials of moxibustion. Further comments will be solicited from the experts of the CONSORT Group, the STRICTA Group, acupuncture and moxibustion societies, and clinical trial authors for optimizing the STRICTOM.

In this article, we introduced the concept and technology of network biology and network pharmacology, and proposed the possible strategy for building the methodology for discovering and developing Chinese medicine based on network biology. The concept of network pharmacology of Chinese medicine and its potential application in the modernization of traditional Chinese medicine was also discussed.
Animals ; Biology ; methods ; Drug Therapy ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Medicine, Chinese Traditional ; methods

OBJECTIVETo discover and interpret the correlations between traditional Chinese medicine (TCM) slices and their properties such as function, symptom and channel tropism by constructing the relationship network using network pharmacology approaches.

METHODTCM slices related information was extracted from Chinese Pharmacopeia (2010 edition, volume I) by text mining, and was used to construct the TCM slices-symptom relationship network. The corresponding network analysis was also performed.

RESULTThree thousands and sixteen pair of TCM slice-symptom correlation associated with 646 TCM slices was discovered, and the constructed network unfolded the complex relationships between TCM slices. Further network analysis results indicated that the un-annotated function and channel tropism of TCM slice can be revealed by proposed symptom-based network.

CONCLUSIONNetwork pharmacology approaches can be applied in TCM research to discover and interpret the relationships between TCM slices and their properties.

Animals ; Drug Interactions ; Drug Therapy ; Drugs, Chinese Herbal ; analysis ; pharmacology ; Humans ; Medicine, Chinese Traditional

OBJECTIVETo investigate the correlations between multi-compounds of Fufang Danshen formula and their multi targets and multi diseases.

METHODLiterature knowledge of nine major active compounds from Fufang Danshen formula, including tanshinone II(A), salvianolic acid B, protocatechuic aldehyde, danshensu, cryptotanshinone, notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1 and borneol were collected from PubMed. Combined with cardiovascular related diseases and genes from OMIM database, the corresponding multi-compound-multi- target-multi-disease network was constructed and visualized by Cytoscape software.

RESULTAND CONCLUSION: Network analysis showed that the 9 compounds could modulate 42 cardiovascular associated genes (e. g. PPARG, ACE, KCNJ11, KCNQ1, ABCC8, et al), which related to 30 cardiovascular associated diseases including non-insulin-dependent diabetes mellitus, hyperinsulinemic hypoglycemia, hypertension, and coronary heart disease. These results suggested new potential indications of Fufang Danshen formula.

Animals ; Disease ; genetics ; Drug Therapy ; Drugs, Chinese Herbal ; analysis ; pharmacology ; Gene Regulatory Networks ; Humans ; Salvia miltiorrhiza ; chemistry