1.Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
Chi Hyun AHN ; Won Woo LEE ; Yun Chan JUNG ; Ji Ae SHIN ; Kyoung Ok HONG ; Sujung CHOI ; Neeti SWARUP ; Jihoon KIM ; Min Hye AHN ; Minjung JUNG ; Sung Dae CHO ; Bohwan JIN
Laboratory Animal Research 2019;35(4):194-201
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied yet. Here, we attempted to confirm antitumor activity of TW37 in human oral cancer. TW-37 significantly inhibited cell proliferation and increased the number of dead cells in MC-3 and HSC-3 human oral cancer cell lines. TW-37 enhanced apoptosis of both cell lines evidenced by annexin V/propidium iodide double staining, sub-G1 population analysis and the detection of cleaved poly (ADP-ribose) polymerase and caspase-3. In addition, TW-37 markedly downregulated the expression of Bcl-2 protein, while not affecting Bcl-xL or myeloid cell leukemia-1. In vivo, TW-37 inhibited tumor growth in a nude mice xenograft model without any significant liver and kidney toxicities. Collectively, these data reveal that TW-37 may be a promising small molecule to inhibit human oral cancer.
Animals
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Apoptosis
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Caspase 3
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Cell Line
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Cell Proliferation
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Heterografts
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Humans
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Kidney
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Liver
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Mice
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Mice, Nude
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Mouth Neoplasms
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Myeloid Cells