1."Four Common Characteristics" of Liver and Eyes and Research Ideas Inspired by "Liver Opens at Eyes"
Suhui XIONG ; Jiahui YU ; Miao SUN ; Bohou XIA ; Zhimin ZHANG ; Yamei LI ; Zhe SHI ; Qiuxian PENG ; Duanfang LIAO ; Chun LI ; Qinhui TUO ; Jingchen XIE ; Limei LIN
Chinese Journal of Experimental Traditional Medical Formulae 2023;29(17):185-194
The theory of "liver opens at the eyes" was first seen in Yellow Emperor's Internal Canon of Medicine, which is the ancient people's summary of the connection between the liver and the eyes. The theory of "liver opens at the eyes" suggests the characteristic of "co-damage and co-recover of liver and eyes". It has been found in clinical practice that liver diseases and eye diseases often occur together, and "liver and eyes co-recover" is an ideal choice. The key to achieving "liver and eyes co-recover" is to analyze its pharmacological material basis and mechanism. With the development of modern medicine, more and more evidence indicates that the liver and eyes have complex and close relationships in physiological and pathological aspects. In a pathological state, there is a phenomenon of "liver and eyes co-damage", and after the intervention of traditional Chinese medicine, "liver and eyes co-recover" occurs. "Liver and eyes co-damage and co-recover" can be explained through the "co-material basis and co-action mechanism". On this basis, the research group tentatively proposed that the liver and eyes had "four common characteristics" (4CCs), namely "co-damage, co-recover, co-material basis, and co-action mechanism" from the theoretical connotation of traditional Chinese medicine, clinical practice, and molecular biology. Additionally, the group also took the intervention of Prunella vulgaris, traditional Chinese medicine, for removing liver fire and improving eyesight on immune liver injury (ILI) and allergic conjunctivitis (AC) as examples to analyze 4CCs. This project aims to deeply analyze the scientific connotation of the theory of "liver opens at the eyes", reveal the common characteristics and biological essence of liver and eyes, explore a new research paradigm of "liver and eyes co-recover", and provide a reference for the study of common problems of multi-organ associated diseases.
2.Delayed diagnosis is associated with greater disease severity of chronic obstructive pulmonary disease.
Xianru PENG ; Minyu HUANG ; Wenqu ZHAO ; Yafei YUAN ; Bohou LI ; Yanmei YE ; Jianpeng LIANG ; Shunfang ZHU ; Laiyu LIU ; Shaoxi CAI ; Haijin ZHAO
Journal of Southern Medical University 2018;38(12):1448-1452
OBJECTIVE:
To investigate the association of the time of initial diagnosis with the severity of chronic obstructive pulmonary disease (COPD).
METHODS:
A total of 803 patients who were diagnosed to have COPD for the first time in our hospital between May 2015 to February 2018 were enrolled in this study.The diagnoses of COPD and asthma COPD overlap (ACO) were made according GOLD guidelines and european consensus definition.Lung function of the patients was graded according to the GOLD guidelines.
RESULTS:
The patients with COPD had a mean age of 61.8±9.9 years,including 726 male and 77 female patients.The course of the patients (defined as the time from symptom onset to the establishment of a diagnosis) was 3(0.5,8) years.Among these patients,85.2% had a moderate disease severity (FEV1%<80%),and 48.3% had severe or very severe conditions (FEV1%<50%);47.0% of them were positive for bronchial dilation test.In the overall patients,295(36.7%) were also diagnosed to have ACO,and the mean disease course of ACO[3(1,9) years]was similar to that of COPD[3(0.5,8) years](>0.05).A significant correlation was found between the disease course and the lung function of the patients.Multiple linear regression analysis showed that an older age and a longer disease course were associated with poorer lung functions and a greater disease severity.
CONCLUSIONS
The delay of the initial diagnosis is significantly related to the severity of COPD.
Age Factors
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Aged
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Asthma
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diagnosis
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Delayed Diagnosis
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adverse effects
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Disease Progression
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Female
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Humans
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Lung
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physiopathology
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Male
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Middle Aged
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Pulmonary Disease, Chronic Obstructive
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diagnosis
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physiopathology
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Severity of Illness Index
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Time Factors