BACKGROUND: This prospective cohort study was carried out to investigate the relation of lifestyle variables to total mortality in residents aged 60-64 of a rural community in Korea. METHODS: A total of 1,042 residents was interviewed by face-to-face survey for baseline data collection in 1996 and 955 residents were successfully followed up until April 2002, among which 91 died. RESULTS: In univariate logistic regression, consumption of cigarette per day, duration of smoking, status of smoking, frequency of drinking per month, status of drinking, average duration of TV watching per day and average duration of sleeping were statistically significant, predicting total mortality. None of the variables reflecting leisure-time physical activities were statistically significant. Adjusting for sex, age, education, current as well as past chronic diseases history, and limitation of daily living with multiple logistic regression, those smoking more than 40 years and current smokers showed reduced, but statistically significant RRs, 1.89 (95% CI 1.05-3.41) and 1.82 (95% CI 1.01-3.25), respectively. Sleeping more than 10 hours a day showed RR, 2.41 (95% CI 1.11-5.22). CONCLUSION: These results suggested that some lifestyle variables, smoking and sleeping were predictive of total mortality while drinking, TV watching and leisure-time physical activities were not.
Chronic Disease ; Cohort Studies* ; Data Collection ; Drinking ; Education ; Korea ; Life Style* ; Logistic Models ; Mortality* ; Motor Activity ; Prospective Studies ; Rural Population* ; Smoke ; Smoking ; Tobacco Products

Purpose: Exercise is a representative noninvasive treatment that can be applied to various diseases. We studied the effect of resistance exercise on motor function and spatial learning ability in Parkinson disease (PD) mice. Methods: The rotarod test and beam walking test were conducted to evaluate the effect of resistance exercise on motor function, and the Morris water maze test was conducted to examine the effect of resistance exercise on spatial learning ability. The effect of resistance exercise on brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) expression and 5’-adenosine monophosphate-activated protein kinase (AMPK) phosphorylation was investigated by Western blot analysis. New cell generation was confirmed by immunohistochemistry for 5-bromo-2’-deoxyuridine. Results: Resistance exercise improved coordination, balance, and spatial learning ability in PD mice. Resistance exercise enhanced new cell production, BDNF and TrkB expression, and AMPK phosphorylation in PD mice. The effect of such resistance exercise was similar to that of levodopa application. Conclusions In PD-induced mice, resistance exercise enhanced AMPK phosphorylation to increase BDNF expression and new neuron generation, thereby improving spatial learning ability. Resistance exercise is believed to help improve symptoms of PD.