No abstract available.
Bilirubin* ; Humans ; Infant, Newborn*

The aim of this study is to evaluate pituitary-ovarian function at different postpartum periods during the lactational amenorrhea in order to understand the mechanism by which puerperal lactation is associated with a protracted period of amenorrhea and natural infertility. Ninety four lactating women and 119 lactating women with menstruation, aged between 21 and 38 years, volunteered for this study. The pituitary was relatively insensitive to LH-RH during the first 3 weeks following delivery. The recovery of FSH responsiveness to LH-RH occurred earlier than that of LH. Normal FSH response resumed in the 2nd week while the LH response, although not normal, started at the 3rd week postpartum. Pituitary responsiveness after the 5th week postpartum was similar to that occurring in normally menstruating women, except that FSH response was exagerated. Serum prolactin levels were elevated above 160 ng/ml until the 5th week postpartum and decreased to 84.2 ng/ml in the 6th week postpartum. It appears that at least one reason for anovulation during the first four weeks following delivery is the relative insensitivity of the pituitary to hypothalamic stimulation. Prolactin does not seem to modulate pituitary responsiveness to LH-RH. In order to clarify hormonal profiles during the lactational amenorrhea beyond the 5th week puerperium, serum levels of LH, FSH, prolactin, estradiol and progesterone were determined during different postpartum periods. Serum FSH and LH levels during 1-10 months postpartum were similar to basal levels seen during the normal menstrual cycle. Serum estradiol concentrations throughout 1-10 months postpartum, however, were significantly decreased as compared with the levels during the follicular phase of the normal menstrual cycle. Serum prolactin levels were elevated throughout 1-10 months postpartum in lactating amenorrhic women but decreased as the postpartum period lengthened. As compared with lactating amenorrhic women, lactating women with resumed menstruation showed a decrease in prolactin levels from 89.20 ng/ml to 51.39 ng/ml at 1-3 months, from 75.08 ng/ml to 49.99 ng/ml at 4-6 months, and from 54.73 ng/ml to 28.74ng/ml at 7-10 months postpartum. These results suggest that the apparent anovulation seen beyond 5th week postpartum during lactation was not due to pituitary insensitivity to LH-RH. Rather, prolactindependent mechanism interfering with cyclic activity may be operative during long term lactation.
Amenorrhea/etiology* ; Female ; Gonadorelin/pharmacology ; Gonadotropins, Pituitary/secretion ; Human ; Lactation* ; Ovary/physiology* ; Pituitary Gland/physiology* ; Pregnancy ; Prolactin/physiology ; Puerperium*

PURPOSE: This post-marketing surveillance study (NCT00750360) assessed the safety and reactogenicity of an inactivated, trivalent split-virion influenza vaccine licensed for use in the Korea since 2002. METHODS: Eight hundred and eighty three subjects aged > or =6 months received a single dose of the vaccine; an additional dose was administered to those aged <9 years and unprimed with an influenza vaccine. Four hundred and eleven subjects used diary cards to record safety information; this report presents data from these subjects. Incidence of solicited local, general and unsolicited adverse events (4-days and 21-days post-vaccination follow-up periods, respectively) were recorded. Serious adverse events (SAEs) were recorded throughout the study period. RESULTS: Injection site pain (subjects aged <6 years: 12.6% of subjects, > or =6 years: 34.7%), fever (<6 years: 1.3%) and myalgia (> or =6 years: 13.9%) were the most frequently recorded solicited local and general adverse events. Grade 3 solicited adverse events were reported by < or =4.0% subjects. No vaccine-related SAEs were recorded (KFDA criteria). CONCLUSION: Considering the vaccine's well-established immunogenicity and its favourable safety and reactogenicity profile across all age groups and its high coverage rate in Korea, it may be recommended as a candidate to facilitate annual seasonal influenza vaccination for all ages as part of the Korean National Immunization Program.
Aged ; Fever ; Follow-Up Studies ; Humans ; Immunization Programs ; Incidence ; Influenza Vaccines ; Influenza, Human ; Korea ; Seasons ; Vaccination

The purpose of this study was to investigate influence of each file step of ProTaper(R) system on canal transportation. Twenty simulated canals were prepared with either engine-driven ProTaper(R) or manual ProTaper(R). Group R-resin blocks were instrumented with rotary ProTaper(R) and group M-resin blocks were instrumented with manual ProTaper(R). Pre-operative resin blocks and post-operative resin blocks after each file step preparation were scanned. Original canal image and the image after using each file step were superimposed for calculation of centering ratio. The image after using each file step and image after using previous file step were superimposed for calculation of the amount of deviation. Measurements were taken horizontally at five different levels (1, 2, 3, 4 and 5 mm) from the level of apical foramen. In rotary ProTaper(R) instrumentation group, centering ratio and the amount of deviation of each step at all levels were not significantly different (p > 0.05). In manual ProTaper(R) instrumentation group, centering ratio and the amount of deviation of each step at all levels except of 1 mm were not significantly different (p > 0.05). At the level of 1 mm, F2 file step had significantly large centering ratio and the amount of deviation (p < 0.05). Under the condition of this study, F2 file step of manual ProTaper(R) tended to transport the apical part of the canals than that of rotary ProTaper(R).
Dental Pulp Cavity* ; Tooth Apex ; Transportation

The purpose of this study was to analyze the stress distribution aspect of unrestored and restored combined shape (wedge shape occlusally and saucer shape gingivally) class V cavity, which found frequently in clinical cases. A maxillary second premolar restored with a combined shape class V composite restorations were modeled using the three dimensional finite element method. Static occlusal load of 170 N was applied on lingual incline of buccal cusp at the angle of 45degrees with the longitudinal axis of the tooth. And three dimensional finite element analysis was taken by ANSYS (Version 6.0, Swanson Analysis System Co., Houston, U.S.A) program which represent the stress distribution on unrestored and restored cavity wall and margin. The conclusions were as follows. 1. Compared to the unrestored cavity, Von Mises stress at the cementoenamel junction and line angle of the cavity base were reduced and in restored cavity. 2. Von Mises stress at the occlusal and cervical cavity margin and wall were increased in restored cavity in comparison with the unrestored cavity. 3. In the hybrid and hybrid/flowable composite resin restoration, Von Mises stress at the cementoenamel junction and line angle of the cavity base were reduced more than in the flowable restoration. 4. In the hybrid and hybrid/flowable composite resin restoration, Von Mises stress at the occlusal and cervical cavity margin and wall were increased more than in the flowable restoration.
Axis, Cervical Vertebra ; Bicuspid ; Finite Element Analysis ; Tooth ; Tooth Cervix

The relationship between hypercalcemic crisis and pancreatitis, first described in patients with hyperparathyroidism, still remains controversial. Acute pancreatitis may complicate the clinical course of hyperparathyroidism, particularly when the degree of hypercalcemia is severe. The incidence of hyperparathyroidism presenting as acute pancreatitis appears to be steadily decreasing, possibly reflecting the earlier diagnosis of asymptomatic hyperparaparathyroidism due to widespread application of screening methods. Here, we report two patients with primary hyperparathyroidism manifesting clinically as acute pancreatitis. One patient died of progessive pancreatitis and uncontrolled sepsis. The other patient was fullly recovered by emergent parathyroidectomy followed by medical management of hypercalcemia.
Diagnosis ; Humans ; Hypercalcemia ; Hyperparathyroidism* ; Hyperparathyroidism, Primary ; Incidence ; Mass Screening ; Pancreatitis* ; Parathyroidectomy ; Sepsis

The purpose of this study was to compare the shaping ability of the two different Ni-Ti file systems and the two different engine systems in simulated canals. A total of four groups of each 10 were tested. Each group was instrumented with HeroShaper(R)and Endo-Mate2(R) (Group HE), HeroShaper(R) and Tecnika(R) (Group HT), ProFile(R) and Endo-Mate2(R) (Group PE), and ProFile(R) and Tecnika(R) (Group PT). Canal preparation time was recorded. The images of pre- and post- instrumented root canals were scanned and superimposed. The amounts of increased width and centering ratio were measured and calculated at apical 1, 3 and 5 mm levels. These data were statistically analyzed with one-way ANOVA and Duncan's multiple range test The results of this study were as follows; 1. Canal preparation time of HT group was the shortest (p < 0.05). 2. The amount of increased canal width in HE group was significantly larger than PT group at apical 1 mm level (p < 0.05). At apical 3 mm level, PT group was significantly smaller than other groups (p < 0.05). At apical 5 mm level, PE group was significantly larger than PT group (p < 0.05). 3. The amount of centering ratio in HE group was significantly larger than other groups (p < 0.05). At apical 5 mm level, HT group was significantly larger than PE group and PT group (p < 0.05). Under the condition of this study, torque-controlled endodontic motor is safer than no torque controlled motor, especially when the active file is used.
Dental Pulp Cavity* ; Torque