Background:Complete resection of locally advanced sigmoid colon cancer (LASCC) is sometimes diffcult. Patients with LASCC have a dismal prognosis and poor quality of life, which has encouraged the evaluation of alternative multimodality treatments. This prospective study aimed to assess the feasibility and effcacy of neoadjuvant chemora?diotherapy (neoCRT) followed by surgery as treatment of selected patients with unresectable LASCC.
Methods:We studied the patients with unresectable LASCC who received neoCRT followed by surgery between October 2010 and December 2012. The neoadjuvant regimen consisted of external?beam radiotherapy to 50Gy and capecitabine?based chemotherapy every 3weeks. Surgery was scheduled 6–8weeks after radiotherapy.
Results:Twenty?one patients were included in this study. The median follow?up was 42months (range, 17–57months). All patients completed neoCRT and surgery. Resection with microscopically negative margins (R0 resection) was achieved in 20 patients (95.2%). Pathologic complete response was observed in 8 patients (38.1%). Multivisceral resection was necessary in only 7 patients (33.3%). Two patients (9.5%) experienced grade 2 postopera?tive complications. No patients died within 30days after surgery. For 18 patients with pathologic M0 (ypM0) disease, the cumulative probability of 3?year local recurrence?free survival, disease?free survival and overall survival was 100.0%, 88.9% and 100.0%, respectively. For all 21 patients, the cumulative probability of 3?year overall survival was 95.2% and bladder function was well preserved.
Conclusion:For patients with unresectable LASCC, preoperative chemoradiotherapy and surgery can be performed safely and may result in an increased survival rate.

To study the application effect of enterprise WeChat platform in the process of residency teaching management. Fujian Provincial Maternal and Child Health Care Hospital introduced the enterprise WeChat platform in the process of standardized residency training management. Then, residents and rotation departments carried out various activities of standardized residency training through the WeChat platform, and submitted the results of teaching tasks. At last, relevant evaluation data of the enterprise WeChat platform were collected through the network by the teaching management department. At present, there were 732 users, the cumulative usage rate of users reached 100%, the timely delivery rate of teaching materials increased by 31.02%, and 100% of the residents believed that compared with the paper method, they were more inclined to use the enterprise WeChat platform for attendance checking, teaching quality evaluation and questionnaire survey. Besides, the work flow and efficiency of the teaching management department were significantly improved.