Anti-Bacterial Agents ; adverse effects ; Child, Preschool ; Clindamycin ; adverse effects ; Humans ; Infant ; Male ; Paraplegia ; chemically induced

Objective To explore the impact of partial or complete rupture of the tibiofibular syndesmosis on the biomechanical properties of the ankle joint.Methods Six fresh cadaveric specimens of adult ankle were used for creation of 3 models of tibiofibular syndesmosis.In model A,the medial and lateral ligaments of the ankle joint and the tibiofihular syndesmosis were intact.In model B,only the anterior lower tibiofibular ligament was broken.In model C,all inferior tibiofibular ligaments were broken.The 3 models were tested with an electronic pressure sensor in a BOSE material testing machine respectively at 5 positions:10° dorsal extension,20° inversion,20° eversion,20° plantar flexion,and neutral position.The peak values and locations of the compressive stresses of the 3 models at 5 positions were recorded.All the data were collected and analyzed using IBM SPSS 22.0 statistical software.Results Model A exhibited the smallest average stress at all the 5 positions,followed by model B and model C,with significant differences between groups (P ＜ 0.05).The locations of main compressive stress at the neutral position,10° dorsal extension,and 20° plantar flexion in model B and model C tended to expand outwards compared with model A,especially in model C.Conclusions Rupture of the anterior lower tibiofibular ligament and inferior tibiofibular ligaments may increase the compressive stress on the ankle joint,especially rupture of the inferior tibiofibular ligaments.The location of main compressive stress tends to expand outwards when the anterior lower tibiofibular ligament and inferior tibiofihular ligaments are broken,especially the inferior tibiofibular ligaments.

Objective:To study the expression and clinical significance of GPRC5A and SOCS3 in colorectal carcinoma.Methods:SP immunochemical method was performed to detect the expression of GPRCSA and SOCS3 in 45 cases of colorectal carcinoma,25 cases of colorectal adenomas and 22 cases of normal colorectal tissues.Results:1)Expression of GPRC5A in colorectal cancinoma tissue (22.2％) was significantly lower than that in adenomas tissue (52.0％,P＞0.05).The Latter was significantly lower than that in normal colorectal tissue (81.8％,P＜0.05).GPRC5Awas closely related to lymph node metastasis,Duke's stages and the deepness of invasion (P＜0.05).2) Expression of SOCS3 in colorectal cancinoma tissue (24.4％) was significantly lower than that in adenomas tissue (56.0％,P＜0.01).The Latter was significantly lower than that in normal colorectal tissue (86.4％,P＜0.05).SOCS3 was closely related to pathological differentiation,the deepness of invasion,Duke's stages and lymph node metastasis (P＜0.05).3)The expression of GPRC5A was positive correlated with SOCS3 (P＜0.05).Conclusions:The reduced expressions of GPRC5A and SOCS3 may participate in the occurence and development of colorectal carcinorma,suggesting that GPRC5A and SOCS3 may act as biological markers for evaluating the malign degree,prognosis and therapeutic targets of colorectal carcinorma.

Objective Analyse the causes,diagnosis and treatment for delayed hemorrhage after distal radical gastrectomy.Methods Retrospective study on 45 patients combined with intro-abdominal hemorrhage after distal radical gastrectomy from January 2008 to June 2013.Results Thirteen patients combined with delayed hemorrhage in these 45 patients,all of 13 patients had intro-abdominal hemorrhage in 1week to 4 weeks after operation.And 5 of the 13 patiens were intermittent intro-abdominal hemorrhage 1 week after operation,these patients were demonstrated the blood come from gastroduodenal artery pseudoaneurysm fracture by CT and DSA examine,and they were cured by interventional embolization.Other 8 patients were marginal ulcer hemorrhage diagnosed by gastroscope,and they stoped bleeding with the help of gastroscope.Conclusions The causes of delayed hemorrhage after distal radical gastrectomy were complicated,and CT,DSA and endoscope can use for diagnosis.What was more,interventional embolization and endoscope were helpful for curing the intro-abdominal hemorrhage,avoiding re-operation.

Myocardial ischemia-reperfusion injury (MI/RI) is an inflammatory cascade process involving the interaction of multiple factors.In recent years,more and more evidence suggests that NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome,an important component of the innate immune system,is closely associated with the inflammatory damage of MI/RI.Furthermore,blockage of NLRP3 inflammasome or the release of its downstream pro-inflammatory cytokines may provide new therapeutic targets for this disorder.

Objective To investigate the mechanism of recombinant human growth hormone(rhGH) in articular cartilage defect repair in vivo.Methods The cylindrical,full-thick articular cartilage defects,(3.5 mm) in diameter,were made in the knee joints of 25 rabbits.rhGH of 0.1 U/kg was injected into the right knee joints 3 times a week for 4 weeks and equal volume of physiological saline to the left knee joints as control.The animals were killed respectively in 4,6,8,12,24 weeks,and the macroscopic,histologic and ultrastractural examinations were performed.Results The repairing process in experimental group was faster and better than that in the control.In the experimental groups,the defect was filled on week 4,the regenerated cartilage mainly in the shallow region and fibrous tissue in the deep region;on week 24,the regenerated tissue was morphologically close to the neighbour normal cartilage,hard to differentiate by macroscopy;Light microscopy showed the defect recovered to normal cartilage structure and the electron microscopy showed a large quantity of mature cartilage cells.In the control groups,the defect was of shallow introcession,mainly of fibrous tissue.The histological examination showed the significant difference between experimental and control groups(P

Objective To investigate the diagnostic value of fine needle aspiration biopsy for children with thyroid nodules.Methods Eleven children with thyroid nodule were examined by fine needle aspiration biopsy.The cytologic features of thyoid nodules were observed by the light microscope.The pathological sections of thyroid nodules were acquired and compared with fine needle aspiration biopsy.Results Eleven cases were diagnosed by fine needle aspiration biopsy including nodule goiter 4 cases,papillary thyroid carcinoma 2 cases,follicular adenoma 2 cases,medullary carcinima 1 cases,Hashimoto′s thyroiditis 1 case and cyst 1 case.Compared with pathological section,10 cases were diagnosed correctly and one was misdiagnosis.Conclusion Fine needle aspiration biopsy is a valuable methods to the diagnosis of children with thyroid nodules.

Purpose: This study aimed to assess the perception and performance of antimicrobial stewardship among clinical nurses and to contribute to establishing their role through an Importance-Performance Analysis(IPA) matrix. Methods: The study included 203 nurses working in hospitals of general hospital level or higher. Data collection took place from April 9 to May 6, 2024. Data analysis involved descriptive statistics, t-tests, ANOVA, Scheffé́ tests, and IPA analysis. Results: The average perception score for antimicrobial stewardship was 4.42±0.46, while the performance score was 3.96±0.53. Significant differences in perception and performance were observed across several ares: observation of patients, checking with/suggesting to physician based on assessments, implement tests and antimicrobial administration, patient education and support, coordinating multiple disciplines and institutions, acquiring up to date knowledge(p<.050). Perception was highest in the area of implement tests and antimicrobial administration but lowest in coordinating multiple disciplines and institutions. Conclusion To establish the specific role of nurses in antimicrobial stewardship, improving nurse perception and fostering collaboration with various experts are essential. Developing educational programs and institutional support tailored to nurses is necessary to address areas identified for improvement in both perception and performance.

Purpose: This study aimed to assess the perception and performance of antimicrobial stewardship among clinical nurses and to contribute to establishing their role through an Importance-Performance Analysis(IPA) matrix. Methods: The study included 203 nurses working in hospitals of general hospital level or higher. Data collection took place from April 9 to May 6, 2024. Data analysis involved descriptive statistics, t-tests, ANOVA, Scheffé́ tests, and IPA analysis. Results: The average perception score for antimicrobial stewardship was 4.42±0.46, while the performance score was 3.96±0.53. Significant differences in perception and performance were observed across several ares: observation of patients, checking with/suggesting to physician based on assessments, implement tests and antimicrobial administration, patient education and support, coordinating multiple disciplines and institutions, acquiring up to date knowledge(p<.050). Perception was highest in the area of implement tests and antimicrobial administration but lowest in coordinating multiple disciplines and institutions. Conclusion To establish the specific role of nurses in antimicrobial stewardship, improving nurse perception and fostering collaboration with various experts are essential. Developing educational programs and institutional support tailored to nurses is necessary to address areas identified for improvement in both perception and performance.

Purpose: This study aimed to assess the perception and performance of antimicrobial stewardship among clinical nurses and to contribute to establishing their role through an Importance-Performance Analysis(IPA) matrix. Methods: The study included 203 nurses working in hospitals of general hospital level or higher. Data collection took place from April 9 to May 6, 2024. Data analysis involved descriptive statistics, t-tests, ANOVA, Scheffé́ tests, and IPA analysis. Results: The average perception score for antimicrobial stewardship was 4.42±0.46, while the performance score was 3.96±0.53. Significant differences in perception and performance were observed across several ares: observation of patients, checking with/suggesting to physician based on assessments, implement tests and antimicrobial administration, patient education and support, coordinating multiple disciplines and institutions, acquiring up to date knowledge(p<.050). Perception was highest in the area of implement tests and antimicrobial administration but lowest in coordinating multiple disciplines and institutions. Conclusion To establish the specific role of nurses in antimicrobial stewardship, improving nurse perception and fostering collaboration with various experts are essential. Developing educational programs and institutional support tailored to nurses is necessary to address areas identified for improvement in both perception and performance.