Objective To evaluate the efficacy and safety of combined intrapleural therapy with bevacizumab and cisplatin in controlling malignant pleural effusion(MPE)caused by non?small cell lung cancer(NSCLC). Methods A total of 63 NSCLC study subjects with MPE were randomly assigned to one of two groups(A and B). Group A(bevacizumab,n=32)received intrapleural bevacizumab(5 mg/kg)with cisplatin(40 mg/m2) therapy once a week for a total of three cycles. Group B(cisplatin,n=31)received intrapleural cisplatin therapy alone with the same dose and cycle. Pleural fluid was collected from both groups prior to and after treatment. The levels of VEGF in the pleural fluid were determined by ELISA. The cura?tive effect and adverse reaction were observed and follow?up was conducted. Results In 63 evaluable study subjects,the curative efficacy in the be?vacizumab group was significantly higher than that found in the cisplatin group(84.3%vs 61.3%,respectively,P<0.05). But the overall survival (OS)of the two groups showed no statistically significant difference(13.0 months vs 12.0 months,P>0.05). After treatment,The VEGF levels in the MPE were significantly decreased in both groups. In the bevacizumab group,the levels of VEGF in the pleural fluid were significantly lower com?pared to those of the cisplatin group after treatment,showing greater efficacy(P<0.05). The VEGF levels of the two groups whose treatment was in?valid had no statistically significant difference(P=0.079). There was no significant difference in gradeⅢ/Ⅳadverse events between the two groups. All procedures were well tolerated by the patients. Conclusion Combined intrapleural therapy with bevacizumab and cisplatin was effective and safe in managing NSCLC?mediated MPE. The patients showed high tolerance to the therapy. For prediction of local treatment efficacy of bevaci?zumab using the VEGF expression levels in MPE,further research was needed.

Objective To study the inhibitory effects of stachyose on the hyperacute rejection in pig-to-human heart xenotransplantation.Methods A pig-to-human xenogeneic heart transplantation model was established based on an in vitro free heart blood perfusion system.The pig hearts were di- vided into two groups:group A(pig hearts treated with human blood perfusion as control)and group B(pig hearts treated with human blood plus stachyose perfusion).After perfusion for 1h,the heart xenografts were examined for deposit of lgG and IgM by immunohistochemistry and pathological analy sis.Results The mean survival time of perfusion hearts in groups A and B was(9.5?2.5)min and (46.8?8.1)min respectively(P

Adult ; Elbow Joint ; injuries ; Female ; Humans ; Joint Dislocations ; therapy ; Musculoskeletal Manipulations ; Radius ; abnormalities ; Radius Fractures ; therapy ; Synostosis ; therapy ; Ulna ; abnormalities

BACKGROUND: Patients with amnestic mild cognitive impairment (MCI)were considered to be going to develop into Alzheimer disease, and were the high-risk group of Alzheimer disease.OBJECTIVE: To study the implicit and explicit memory in the patient with amnestic MCI. DESIGN: Homochronous and controlled observation.SETTING: Neurological Department of the Southern Building of General Hospital of Chinese PLA.PARTICIPANTS: The research was carried out at Neurological Department of the Southern Building of General Hospital of Chinese PLA from January to June 2003. Totally 20 male patients with amnestic mild MCI,with the average age of (78.7±4.9) years and the average educational time of (8.2±1.0) years, selected from neurological out-patient clinic and ward of southern building of General Hospital of Chinese PLA, Complaint memory losing and confirmed by the relatives and close friends of the patients, Mini-mental state examination (MMSE) ≥24, activity of daily living (ADL)＜26, and clinical dementia rating equal to 0.5, Objective memory examination score reduced compared to the examiners' educational background,the memory quotient recorded by clinical memory sheet to be 63-77 (lower than the normal value with 1.5-2.5 standard deviation), were accepted, and determined as experiment group.Totally 20 healthy male veterans selected from Beijing area, with the average age of(77.9±4.7) years and the average educational time (8.1±1.1) years were selected as control group. All subjects volunteered to take part in_the examination.METHODS: Explicit memory included word free recall and re-recognition task. The Chinese characters were selected from the 1000 most commonly used ones in the books of primary and middle schools. The 30 double characters-words were chosen and randomly divided into two tasks. Recall task included 10 double character words that were target words. Re-recognition task included 20 double character words, of which one half were target words, and the other half were interfering words. Implicit memory included word free recall and character-root-complementary task. The Chinese characters were from the same source as mentioned before. Thirty Chinese characters were chosen in free recall task at beginning. These Chinese characters at least had possibility of composing over 4 commonly used double character-words in primary and middle school books. One double-Chinese character-word in four possibilities was randomly selected and the total was 30 words. Then these 30 words were divided into two groups, one was target group and the other was interfering word. All selected Chinese characters were composed either up-down structure or right-left structure. Taking a part of the Chinese character would leave a characterroot. There were 30 character-roots and they were never the same each other.There were at least four possibilities to form a Chinese character for each root as properly matching among 1000 commonly used Chinese characters.At first, the subjects were asked to read the target words loudly for 3 times in 4 tasks and tried to remember all the target words (characters) and were told to test their memorization later on. The target words (or characters)would appear in one-minute interval. The subjects were asked to repeat the words (or characters) appeared before as many as possible based on their memory in free recall task and they did not have to remember the words (or characters) in order. The correct recall rate for 10 target words was calculated. In re-recognition task, the target words and interfering words were mixed up and appeared one by one in random order and the subjects were asked to tell if the words appeared before. The correct rate of 20-word rerecognition was calculated. In free recall task, the first character in target words was mixed with the first character in interfering words and they appeared one by one in random order. The subjects were asked to form any two-character-word with appeared Chinese characters and wrote down the first word thought of in test sheet. The hitting rate of target words and interfering words were calculated. t-test for independent samples was carried 9ut respectively between the two groups.MAIN OUTCOME MEASURES: ① Semantic priming effect (the hitting rate of target words in word free recall task and the hitting rate of interfering words) and apperception priming effect (the hitting rate of target words in character-root-complementary task and the hitting rate of interfering words) in the two groups. ② Difference of explicit memory (correct rate of free recall and correct rate of re-recognition) and difference of semantic and apperception priming effect in the two groups.RESULTS: All subjects in the two groups completed the test and entered the final analysis. ① Results of inner-group analysis: In the group of MCI,the hitting rate (0.41±0.15) of target words in word free recall task was significantly higher than that of interfering words (0.31±0.12, P ＜ 0.01),suggesting that there existed semantic priming effect in the patients with amnestic MCI as completing this task. In the character-root-complementary task, the hitting rate of target words (0.17±0.10) was significantly higher than that of the hitting rate of interfering words (0.10±0.07, P ＜ 0.05), suggesting that there existed perceptional priming effect in the patients with amnestic MCI as completing this task. In the control group, the hitting rate of target words (0.45±0.11) was significantly higher than that of the interfering words (0.33±0.10, P ＜ 0.01), suggesting that there existed semantic priming effect in the elderly with normal perception as completing this task as well. In the character-root-complementary task, the hitting rate of target characters (0.18±0.08) was higher than that of interfering characters (0.13±0.07, P ＜ 0.05), suggesting that there existed perceptional priming effect in the elderly with normal perception as completing this task as well. ② Results of inter-groups analysis: Correct rates of free recall and re-recognition in the MCI group was decreased (0.10±0.09, 0.45±0.13,t=9.858, P=0.000; 0.69±0.14, 0.83±0.08, t=3.685, P=0.000). There was not significantly different in Sementic priming effect and perceptional priming effect both in the MCI group and the control group.CONCLUSION: Sementic priming effect and perceptional priming effect were existed both in the MCI experiment group and the control group, but the implicit memory was not significantly different in the two groups. However, the patients with forgetful style MCI were exhibited a decline in explicit memory. Memory function of mild MCI patients was shown double characteristics, i.e. damage of explicit memory and preservation of implicit memory. The double character in memorial function provided theoretical basis for the rehabilitative training of MCI patients.

Objective To investigate the current status of medication compliance of patients with anky-losing spondylifis and analyze its related factors. Methods Seventy-four patients with ankylosing spondylitis were investigated about their general conditions,medication compliance and its related factors.The results were analyzed. Results Thirty-nine patients(52.7%) had good medication compliance while the rest 35 cases has poor medication compliance among which 24 patients with drug withdrawal exceeded 1 month.The medication compliance for patients with disease process of lower than 0.5 year,0.5 to 1.0 year,1 to 2 years and above 2 years was 82.0%,60.0%,25.0%and 31.0%.The logistic regression analysis showed that the disease process,dis-ease knowledge and media advertisement were the main influencing factor for medication compliance,while the age,sex,marital status,education background,adverse reaction,satisfaction degree with medication effect, economic conditions and depression were not major influencing factors. Conclusions About half of patients with anky-losing spondylitis had poor medication compliance,especialy with disease process of above 1 year.The main in-fluencing factors include disease process,disease knowledge and media advertisement.

Objective To explore the efficacy and safety of conversion from calcineurin inhibitor (CNI) to sirolimus (SRL) as major immunosuppressive therapy in lung transplant recipients.Method Retrospective analyses were conducted for the clinical data of all the patients undergoing lung transplantation in Wuxi People's Hospital between January 2011 and December 2014.Sixteen were given conversion treatment with Sirolimus in the postoperative irnmunosuppressive therapy.We analyzed the opportunity and reasons in the conversion treatment,and the safety,effectiveness and complications of the conversion treatment.Result The follow-up period was 8 to 25 months,and the median time of conversion was 6 months after operation (2-18 months).The indications of conversion concluded:malignant tumor (n =8),renal dysfunction (n =5),lymphangioleiomyomatosis (n =1) and intractable diarrhea caused by CNIs (n =2).Four cases suffered from interstitial pneumonitis associated with Sirolimus and one case suffered from spontaneous pneumothorax,and they all conversed back to CNIs.In those patients,cancer recurrence occurred in 4 cases (of them,there were 3 deaths),and 3 patients developed chronic rejection.Those recipients receiving the conversion treatment due to renal dysfunction showed recovery of renal function to some extent.Conclusion It's effective and safe to converse the immunosuppressive therapy based on Sirolimus.Sirolimus should be reduced or withdrawn when interstitial pneumonitis associated with Sirolimus occurred.

Nuclear medical emergency rescue , as an important task for the military , has become a priority in many countries.The U.S.military has accumulated rich experience in the development of nuclear medical emergency rescue forces.This paper analyzes the legal status , roles, responsibilities and tasks of the U .S.military during nuclear emergency rescue as well as the characteristics and current status of nuclear emergency rescue forces , hoping to provide some refer-ences for development of our military nuclear medical emergency rescue forces .

Based on literature research and data analysis, the current development situations of the large comprehensive hospitals in the underdeveloped area were analyzed objectively.In addition, with the practical situation of Guangxi, the article did not only elaborate the necessity of establishing a research oriented hospital, but also the way for the construction of research oriented hospital in the underdeveloped area.

Objective To summarize the treatment results,operative complications and experiences of laparoscopic modified pull-through(Soave)precedure.Methods Twenty children with Hirschsprung disease(HD),16 males and 4 females,with age from 3.5 months to 4 years old,underwent laparoscopic modified pull-through(Soave)precedure under whole anesthesia and tracheal intubation,and the pathological colon was freed by ultrasonic surgical knife.Results All cases were operated on successfully.The average operating time was 132 min.The average resection colon was 35 cm and the average volume of bleeding was about 14 mL without blood transfusion.Two patients had postoperative enterocolitis;3 patients were no complications postoperation,such as constipation,soiling,intestinal obstruction,preianal intestine prolapse or cuff narrowing,and all patients had 1-2 bowel movements per day during a period of 6 months to 3 years follow-up.Conclusion Laparoscopic modified pull-through(Soave)precedure has smaller incision,less bleeding,quick recovery and less complications.

Animals ; Biological Specimen Banks ; utilization ; Humans ; Specimen Handling ; methods ; Tissue Fixation ; methods