1.The value of hepatic ischemic preconditioning in hepatectomy with a prospective randomized controlled study.
Hui HOU ; Xiao-ping GENG ; Li-xin ZHU ; Bo-gen YE
Chinese Journal of Surgery 2009;47(8):586-589
OBJECTIVETo evaluate the value of ischemic preconditioning in clinical hepatectomy.
METHODSA total of 48 unselected patients undergoing liver resection were analyzed by randomized controlled trial from December 2004 to June 2006. Forty-eight unselected patients were randomized into two groups: IP group (5 minutes of ischemia followed by 5 minutes of reperfusion) and control group (received Pringle's maneuver no and no IP was given). Postoperative days 1, 3 and 7, the liver function were checked. Perioperative mortality, morbidity and hospitalized days were compared.
RESULTSIn IP group, ischemic times were 5 - 80 min, mean 31 min, hospitalized days were 13 - 50 days, mean 20 days. In control group, ischemic times were 10 - 60 min, mean 27 min, hospitalized days were 10 - 33 days, mean 17 days. Forty-seven patients were satisfactory with postoperative recovery, except one patient died of chronic liver dysfunction after 3 months postoperatively. Postoperative days 1, 3 and 7, the ALT, AST, TBIL, ALB levels in two groups were not statistically significant (P > 0.05).
CONCLUSIONSThe clinical use of IP through 5 minutes of warm ischemia in this technique of hepatectomy does not protect the liver from hepatic injury induced by the IRI.
Adolescent ; Adult ; Aged ; Child ; Female ; Hepatectomy ; methods ; Humans ; Ischemic Preconditioning ; Liver ; blood supply ; Male ; Middle Aged ; Prospective Studies ; Reperfusion Injury ; prevention & control ; Young Adult
2.Hepatic iron overload in hemochromatosis: a case report.
Gen-dong YANG ; Pu-xuan LU ; Bo-ping ZHOU ; Ru-xin YE ; Jian ZANG ; Jian SU
Chinese Journal of Hepatology 2006;14(8):634-634
Hemochromatosis
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metabolism
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Humans
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Iron Overload
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Liver
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metabolism
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Male
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Middle Aged
3.Retroperitoneal iaparoscopic partial nephrectomy(report of 23 cases)
Shuo WANG ; Qi-Meng LI ; Dan XIA ; Zhi-Gen ZHANG ; Bai-Hua SHEN ; Bai-Ye JIN ; Ge-Ming CHEN ; Dan-Bo FANG ; Li-Ping XIE ; Song-Liang CAI ; Shifang SHI ; Kexiang WEI ;
Chinese Journal of Urology 2001;0(07):-
Objective To report initial experience and the indications of retroperitoneal laparoscop- ic partial nephrectomy.Methods From December 2001 to October 2005,23 patients (including 14 cases of renal cell carcinoma,5 of hamartoma and 4 of duplex kidney) underwent retroperitoneal laparoscopic par- tial nephrectomy.One of the patients had solitary kidney.Results All the operations were successful ex- cept for only 1 requiring conversion to laparoscopic nephrectomy because of bleeding resulting from blocking anterior branch of renal artery.The mean operative time was 121 min (60-240 min),and mean ischemic time was 32 min (20-55 min).The estimated bleeding volume ranged from 100 ml to 300 ml,and no pa- tient needed blood transfusion.Pathology showed negative surgical margins in 14 cases of renal cell carcinoma and confirmed the diagnosis of hamartoma in 5 cases.One patient with duplex kidney required open partial nephrectomy because of renal cystic mass resulting from incomplete resection.Conclusions Retroperito- neal laparoscopic partial nephrectomy offers a new effective and minimally invasive treatment for selected pa- tients with renal mass.The long-term effects of the procedure need further investigation.