1.Associations of unspecified pain, idiopathic pain and COVID-19 in South Korea: a nationwide cohort study
Namwoo KIM ; Jeewuan KIM ; Bo Ram YANG ; Bong-Jin HAHM
The Korean Journal of Pain 2022;35(4):458-467
Background:
Few studies have investigated unspecified or idiopathic pain associated with COIVD-19. This study aimed to provide the incidence rates of unspecified pain and idiopathic pain in patients with COVID-19 for 90 days after COVID-19 diagnosis.
Methods:
A propensity score matched cohort was used, including all patients with COVID-19 in South Korea, and analyzed their electronic medical records. The control group consisted of those who had not had tests for COVID-19 at all. Unspecified pain diagnoses consisted of diagnoses related to pain included in the ICD-10 Chapter XVIII. Idiopathic pain disorders included fibromyalgia, temporomandibular joint disorders, headaches, chronic prostatitis, complex regional pain syndrome, atypical facial pain, irritable bowel syndrome, and interstitial cystitis.
Results:
After matching, the number of participants in each group was 7,911. For most unspecified pain, the incidences were higher in the COVID-19 group (11.7%;95% confidence interval [CI], 11.0–12.5) than in the control group (6.5%; 95% CI, 6.0–7.1). For idiopathic pain, only the headaches had a significantly higher in-cidence in the COVID-19 group (6.6%; 95% CI, 6.1–7.2) than in the control group (3.7%; 95% CI, 3.3–4.1). However, using a different control group that included only patients who visited a hospital at least once for any reasons, the incidences of most unspecified and idiopathic pain were higher in the control group than in the COVID-19 group.
Conclusions
Patients with COVID-19 might be at a higher risk of experiencing unspecified pain in the acute phase or after recovery compared with individuals who had not had tests for COVID-19.
2.Use of the International Classification of Functioning, Disability and Health as a Functional Assessment Tool for Breast Cancer Survivors.
Eun Joo YANG ; Bo ram KIM ; Hyung Ik SHIN ; Jae young LIM
Journal of Breast Cancer 2012;15(1):43-50
PURPOSE: To develop a patient self-completed questionnaire from the items of the Brief Core Set Questionnaire for Breast Cancer (BCSQ-BC) and to investigate the prevalence of specific dysfunctions throughout the course of cancer and treatments. METHODS: From January 2010 to February 2011, 96 breast cancer patients were evaluated with BCSQ-BC developed for clinical application of International Classification of Functioning, Disability and Health (ICF). Quality of life and upper limb dysfunction using disabilities of arm, shoulder and hand (DASH) were assessed. Content validity was evaluated using correlations between BCSQ-BC and European Organization for Research and Treatment of Cancer (EORTC) QLQ and DASH scores. Construct validity was computed using exploratory factor analysis. Kappa statistics were computed for agreement between test-retest ICF data. The level of significance and odds ratios were reported for individuals with early post-acute and long-term context and with total mastectomy and breast conservative surgery. RESULTS: There was consistently good test-retest agreement in patient-completed questionnaires (kappa value, 0.76). Body function, activity and participation subscales are significantly related with EORTC QLQ and DASH. Problems with activity and participation were strongly associated with physical functional domains of EORTC QLQ (r=-0.708, p<0.001) and DASH (r=0.761, p<0.001). The prevalence of dysfunctions varied with type of surgery and time after cancer. Immobility of joint (15% vs. 7%) and lymphatic dysfunction (17% vs. 3%) were indexed more frequently in extensive surgery cases than in conservative surgery. Muscle power (16% vs. 8%), exercise tolerance functions (12% vs. 4%) and looking after one's health (10% vs. 2%) were impaired within 1 year after surgery, while sleep dysfunction (8% vs. 14%) was a major problem over 1 year after surgery. CONCLUSION: The BCSQ-BC identifies the problems comprehensively in functioning of patients with breast cancer. We revealed the interaction with the ICF framework adopting a multifactor understanding of function and disability.
Arm
;
Breast
;
Breast Neoplasms
;
Exercise Tolerance
;
Hand
;
Humans
;
Joints
;
Mastectomy, Simple
;
Muscles
;
Odds Ratio
;
Prevalence
;
Quality of Life
;
Shoulder
;
Survivors
;
Upper Extremity
;
Surveys and Questionnaires
3.Use of the International Classification of Functioning, Disability and Health as a Functional Assessment Tool for Breast Cancer Survivors.
Eun Joo YANG ; Bo ram KIM ; Hyung Ik SHIN ; Jae young LIM
Journal of Breast Cancer 2012;15(1):43-50
PURPOSE: To develop a patient self-completed questionnaire from the items of the Brief Core Set Questionnaire for Breast Cancer (BCSQ-BC) and to investigate the prevalence of specific dysfunctions throughout the course of cancer and treatments. METHODS: From January 2010 to February 2011, 96 breast cancer patients were evaluated with BCSQ-BC developed for clinical application of International Classification of Functioning, Disability and Health (ICF). Quality of life and upper limb dysfunction using disabilities of arm, shoulder and hand (DASH) were assessed. Content validity was evaluated using correlations between BCSQ-BC and European Organization for Research and Treatment of Cancer (EORTC) QLQ and DASH scores. Construct validity was computed using exploratory factor analysis. Kappa statistics were computed for agreement between test-retest ICF data. The level of significance and odds ratios were reported for individuals with early post-acute and long-term context and with total mastectomy and breast conservative surgery. RESULTS: There was consistently good test-retest agreement in patient-completed questionnaires (kappa value, 0.76). Body function, activity and participation subscales are significantly related with EORTC QLQ and DASH. Problems with activity and participation were strongly associated with physical functional domains of EORTC QLQ (r=-0.708, p<0.001) and DASH (r=0.761, p<0.001). The prevalence of dysfunctions varied with type of surgery and time after cancer. Immobility of joint (15% vs. 7%) and lymphatic dysfunction (17% vs. 3%) were indexed more frequently in extensive surgery cases than in conservative surgery. Muscle power (16% vs. 8%), exercise tolerance functions (12% vs. 4%) and looking after one's health (10% vs. 2%) were impaired within 1 year after surgery, while sleep dysfunction (8% vs. 14%) was a major problem over 1 year after surgery. CONCLUSION: The BCSQ-BC identifies the problems comprehensively in functioning of patients with breast cancer. We revealed the interaction with the ICF framework adopting a multifactor understanding of function and disability.
Arm
;
Breast
;
Breast Neoplasms
;
Exercise Tolerance
;
Hand
;
Humans
;
Joints
;
Mastectomy, Simple
;
Muscles
;
Odds Ratio
;
Prevalence
;
Quality of Life
;
Shoulder
;
Survivors
;
Upper Extremity
;
Surveys and Questionnaires
4.Transformation of Recurred Lupus Nephritis from Class IV to Class V.
Jin Ju PARK ; Ji Yeong KWAK ; Ju Yang JUNG ; Bo Ram KOH ; Hyoun Ah KIM ; Chang Hee SUH
Journal of Rheumatic Diseases 2012;19(5):290-294
There are numerous studies about the transformation of renal pathology during lupus nephritis progression. A number of researchers suggest that patients with previous proliferative glomerulonephritis may not need to repeat renal biopsy in relation to treatment strategies. However, the pathology of renal biopsy could offer important information to clinicians about the progression of disease. Here, we report a rare case of the convertion of ISN/RPS classification from a proliferative lesion to a wholly non-proliferative lesion. A 40-year-old female was admitted complaining of generalized edema for 1 month. At the age of 33 she had been diagnosed as SLE with proliferative lupus nephritis. The renal remission was induced with corticosteroid pulse therapy and 12 cycles of intravenous cyclophosphamide treatment. The repeated renal biopsy revealed class V lupus nephritis compared with referential biopsy of class IV-G. A better prognosis is expected with lower activity and a lower chronicity index. Repeat renal biopsy may give useful information relating to the prognosis of nephritis.
Adult
;
Biopsy
;
Cyclophosphamide
;
Edema
;
Female
;
Glomerulonephritis
;
Humans
;
Lupus Nephritis
;
Nephritis
;
Prognosis
5.The Effect of a Potential Antiobesity-Supplement on Weight Loss and Visceral Fat Accumulation in Overweight Women.
Bo Ram CHA ; Jey Sook CHAE ; Jong Ho LEE ; Yang Soo JANG ; Jin Hee LEE ; Jong Wook SON
The Korean Journal of Nutrition 2003;36(5):483-490
Chitosan, hydroxycitrate and L-carnitine have been known to be antiobesity components. The purpose of this study was to evaluate the combined effects of chitosan, hydroxycitrate and L-carnitine mixture as a potential antiobesity supplement in overweight women. Pre-menopausal healthy females who were overweight (percent ideal body weight >110) were included in this study. Forty-nine subjects randomly received a placebo (n=25) or antiobesity-supplement (n=24), which was a mixture of chitosan, hydroxycitrate, and L-carnitine. Before and after the eight-week experimental period, anthropometric parameters, blood components and computerized tomography were measured. At baseline, the two groups were well matched in terms of age, body mass index and lipid profile. After the eight weeks of potential antiobesity supplementation, the subjects' body fat percent had decreased significantly (p<0.001) by 5.6% (39.1+/-1 vs 36.9+/-1%) while lean body mass increased (p<0.01). Vsceral fat area at the L4 vertebra decreased significantly (p<0.01) by 8.6% in the supplemented group and the total fat area at the L4 vertebra showed a tendency to decrease (p=0.051) by 2.4%. Also, in the group given the antiobesity-supplement rather than the placebo, the fasting triglyceride level decreased significantly (p<0.05) by 10.0%. In addition, serum total cholesterol levels in the antiobesity-supplement group showed a tendency to decrease (p=0.159) by 2.7% (194+/-6 vs 189+/-6 mg/dl). No side effects were found in either group during the intervention. In conclusion, the present study demonstrated that taking a mixture of chitosan, hydroxycitrate, and L-carnitine as a potential antiobesity supplement for eight weeks produced advantageous changes in the weight and visceral fat accumulation of overweight women without any side effects.
Adipose Tissue
;
Body Mass Index
;
Carnitine
;
Chitosan
;
Cholesterol
;
Fasting
;
Female
;
Humans
;
Ideal Body Weight
;
Intra-Abdominal Fat*
;
Overweight*
;
Spine
;
Triglycerides
;
Weight Loss*
6.Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.
Jungmee KIM ; Ji Hwan BANG ; Ju Young SHIN ; Bo Ram YANG ; Joongyub LEE ; Byung Joo PARK
Yonsei Medical Journal 2018;59(10):1245-1252
PURPOSE: A high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART). MATERIALS AND METHODS: From a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertension at baseline were analyzed. The use of ART was treated as a time-varying covariate measured as a daily unit. Incidence rate of hypertension was calculated, and Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) with 95% confidence interval (CI) of incident hypertension overall and among subgroups. RESULTS: From the 6493 participants, 24072 person-years (PY) of follow-up were contributed during 2008–2016. The incidence rates of hypertension were 4.6 and 3.6 per 100 PY for abacavir and non-abacavir ART users, respectively. The population attributable fraction of abacavir use on hypertension was 12%. Abacavir exposure did not elevate the risk of hypertension among overall study population [HR, 1.2 (95% CI, 1.0–1.4), p=0.061]. However, those with poor ART adherence, defined as a medication possession ratio < 50% [HR, 1.9 (95% CI, 1.5–2.4), p < 0.0001] or requiring prophylactic antibiotics [HR, 1.2 (95% CI, 1.0–1.3), p=0.023], were at risk of hypertension induced by abacavir, as were men, individuals aged ≥40 years, and patients visiting tertiary hospitals in urban areas. CONCLUSION: When present, poor ART adherence, requiring prophylactic antibiotics, male sex, and older age may warrant additional concern for hypertension in patients treated with abacavir.
Anti-Bacterial Agents
;
Cardiovascular Diseases
;
Cohort Studies*
;
Epidemiology
;
Follow-Up Studies
;
HIV
;
Humans
;
Hypertension*
;
Incidence
;
Male
;
Proportional Hazards Models
;
Tertiary Care Centers
7.Signal Detection for Adverse Events of Finasteride Using Korea Adverse Event Reporting System (KAERS) Database
Ji-Won BAEK ; Bo Ram YANG ; Subin CHOI ; Kwang-Hee SHIN
Korean Journal of Clinical Pharmacy 2021;31(4):324-331
To investigate signals of adverse drug reactions of finasteride by using the Korea Adverse Events Reporting System (KAERS) database. This pharmacovigilance was based on the database of the drug-related adverse reactions reported spontaneously to the KAERS from 2013 to 2017. This study was conducted by disproportionality analysis. Data mining analysis was performed to detect signals of finasteride. The signal was defined by three criteria as proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). The signals of finasteride were compared with those of the other drugs; dutasteride (similar mechanism of action), minoxidil (different mechanism but similar indications for alopecia), silodosin (different mechanism but similar indications for BPH). It was examined whether the detected signals exist in drug labels in Korea. The total number of adverse eventdrug pairs was reported 2,665,429 from 2013 to 2017, of which 1,426 were associated with finasteride. The number of investigated signals of finasteride was 42. The signals that did not include in the drug label were 29 signals, including mouth dry, hypotension, dysuria etc. The signal of finasteride was similar to that of dutasteride and silodosin but was different to that of minoxidil. Early detection of signals through pharmacovigilance is important to patient safety. We investigated 29 signals of finasteride that do not exist in drug labels in Korea. Further pharmacoepidemiological studies should be needed to evaluate the signal causality with finasteride.
8.Comparison of the Safety of Seven Iodinated Contrast Media.
Jong Mi SEONG ; Nam Kyong CHOI ; Joongyub LEE ; Yoosoo CHANG ; Ye Jee KIM ; Bo Ram YANG ; Xue Mei JIN ; Ju Young KIM ; Byung Joo PARK
Journal of Korean Medical Science 2013;28(12):1703-1710
We aimed to determine the characteristic adverse events (AEs) of iodinated contrast media (IOCM) and to compare the safety profiles of different IOCM. This study used the database of AEs reports submitted by healthcare professionals from 15 Regional Pharmacovigilance Centers between June 24, 2009 and December 31, 2010 in Korea. All reports of IOCM, including iopromide, iohexol, iopamidol, iomeprol, ioversol, iobitridol and iodixanol, were analyzed. Safety profiles were compared between different IOCM at the system organ level using the proportional reporting ratio (PRR) and 95% confidence interval (95% CI). Among a total of 48,261 reports, 6,524 (13.5%) reports were related to the use of IOCM. Iopromide (45.5%), iohexol (16.9%), iopamidol (14.3%) and iomeprol (10.3%) were identified as frequently reported media. 'Platelet, bleeding & clotting disorders' (PRR, 29.6; 95%CI, 1.9-472.6) and 'urinary system disorders' (PRR, 22.3; 95% CI, 17.1-29.1) were more frequently reported for iodixanol than the other IOCM. In conclusion, the frequency of AEs by organ class was significantly different between individual media. These differences among different IOCM should be considered when selecting a medium among various IOCM and when monitoring patients during and after its use to ensure optimum usage and patient safety.
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Blood Platelet Disorders/chemically induced
;
Child
;
Child, Preschool
;
Contrast Media/*adverse effects/diagnostic use
;
Databases, Factual
;
Female
;
Humans
;
Infant
;
Infant, Newborn
;
Iodine Radioisotopes/chemistry
;
Male
;
Middle Aged
;
Neoplasms/radionuclide imaging
;
Radiopharmaceuticals/*adverse effects/diagnostic use
;
Urologic Diseases/chemically induced
;
Young Adult
9.Pulmonary hemorrhage as an unusual initial manifestation of systemic lupus erythematosus.
Yun Seok YANG ; Bo Ram CHEON ; Jae Won SHIM ; Deok Soo KIM ; Hye Lim JUNG ; Moon Soo PARK ; Jung Yeon SHIM
Allergy, Asthma & Respiratory Disease 2015;3(5):370-374
Pulmonary hemorrhage as the initial manifestation of systemic lupus erythematosus (SLE) has been rarely reported in children. We present the case of a 10-year-old girl who was admitted to Kangbuk Samsung Hospital with hemoptysis. She had a 5-day history of cough with dyspnea. On physical exam, breath sound was significantly decreased combined with rales on both lung fields. Blood tests revealed pancytopenia, decreased complement levels (C3, 21.28 mg/dL; C4, 3.10 mg/dL), positive antinuclear antibody (>1:640) and anti-double-stranded DNA antibody (262.5 IU/mL). Chest computed tomography revealed patchy ground glass opacity on both lung fields. She had proteinuria and diffuse lupus nephritis (International Society of Nephrology/Renal Pathology Society class IV-G(A)) confirmed by renal biopsy. High-dose methylprednisolone pulse therapy (30 mg/kg/day) was given for 3 days and then switched to a maintenance dose (1 mg/kg/day). Initially hemoptysis resolved after administration of methylprednisolone, but recurred on the 14th day of treatment. She was then treated with cyclophosphamide pulse therapy and hemoptysis subsided without recurrence. She was discharged on the 31st day of admission. She continued to receive monthly cyclophosphamide pulse therapy until the occurrence of leukopenia and then her regimen was switched to mycophenolate and hydroxychloroquine. SLE continues to be well controlled after 18 months of treatment. Recognition of pulmonary hemorrhage as a possible initial manifestation of SLE is crucial for early diagnosis. SLE was successfully treated with good outcome.
Antibodies, Antinuclear
;
Biopsy
;
Child
;
Complement System Proteins
;
Cough
;
Cyclophosphamide
;
DNA
;
Dyspnea
;
Early Diagnosis
;
Female
;
Glass
;
Hematologic Tests
;
Hemoptysis
;
Hemorrhage*
;
Humans
;
Hydroxychloroquine
;
Leukopenia
;
Lung
;
Lupus Erythematosus, Systemic*
;
Lupus Nephritis
;
Methylprednisolone
;
Pancytopenia
;
Pathology
;
Pediatrics
;
Proteinuria
;
Recurrence
;
Respiratory Sounds
;
Thorax
10.Clinical Features of Wrist Drop Caused by Compressive Radial Neuropathy and Its Anatomical Considerations.
Bo Ram HAN ; Yong Jun CHO ; Jin Seo YANG ; Suk Hyung KANG ; Hyuk Jai CHOI
Journal of Korean Neurosurgical Society 2014;55(3):148-151
OBJECTIVE: Posture-induced radial neuropathy, known as Saturday night palsy, occurs because of compression of the radial nerve. The clinical symptoms of radial neuropathy are similar to stroke or a herniated cervical disk, which makes it difficult to diagnose and sometimes leads to inappropriate evaluations. The purpose of our study was to establish the clinical characteristics and diagnostic assessment of compressive radial neuropathy. METHODS: Retrospectively, we reviewed neurophysiologic studies on 25 patients diagnosed with radial nerve palsy, who experienced wrist drop after maintaining a certain posture for an extended period. The neurologic presentations, clinical prognosis, and electrophysiology of the patients were obtained from medical records. RESULTS: Subjects were 19 males and 6 females. The median age at diagnosis was 46 years. The right arm was affected in 13 patients and the left arm in 12 patients. The condition was induced by sleeping with the arms hanging over the armrest of a chair because of drunkenness, sleeping while bending the arm under the pillow, during drinking, and unknown. The most common clinical presentation was a wrist drop and paresthesia on the dorsum of the 1st to 3rd fingers. Improvement began after a mean of 2.4 weeks. Electrophysiologic evaluation was performed after 2 weeks that revealed delayed nerve conduction velocity in all patients. CONCLUSION: Wrist drop is an entrapment syndrome that has a good prognosis within several weeks. Awareness of its clinical characteristics and diagnostic assessment methods may help clinicians make diagnosis of radial neuropathy and exclude irrelevant evaluations.
Arm
;
Diagnosis
;
Drinking
;
Electrophysiology
;
Female
;
Fingers
;
Humans
;
Male
;
Medical Records
;
Neural Conduction
;
Paralysis
;
Parasomnias
;
Paresthesia
;
Posture
;
Prognosis
;
Radial Nerve
;
Radial Neuropathy*
;
Retrospective Studies
;
Stroke
;
Wrist*