No abstract available.
Epidermal Cyst* ; Nevus*

No abstract available.
Epidermal Cyst* ; Nevus*

No abstract available.
Adult ; Humans ; Still's Disease, Adult-Onset

No abstract available.
Adenocarcinoma* ; Neoplasm Metastasis* ; Prostatic Neoplasms

No abstract available.
Diabetes Mellitus, Type 2 ; Exercise ; Humans ; Insulin ; Insulin Resistance

No abstract available.
Osteoma*

BACKGROUND: Clear cells are defined as cells that contain abundant, clear, lightly eosinophilic cytoplasm. On rare occasions, clear cell changes have been observed in actinic keratosis (AK). OBJECTIVE: We aimed to evaluate the cytoplasmic contents of clear cells and the clinicohistopathological features of clear cell AK. METHODS: From 456 cases of histopathologically confirmed AK, we selected 30 cases (6.6%) with greater than 10% of clear cells in the epidermis. We collected the demographic data and clinical features for all specimens. In addition, the specimens were divided into five histopathologic types: hypertrophic, atrophic, Bowenoid, acantholytic, and pigmented. Clear cell distribution was classified into 3 categories: upper, middle, and lower areas of the epidermis. Periodic acid-Schiff (PAS), PAS diastase (d-PAS), and alcian blue staining were carried out, and immunoperoxidase stainings were performed for S-100, HMB45, and cardio embryonic antigen (CEA) to evaluate the origin of the clear cytoplasm. RESULTS: The cheek was the most common site of involvement. The most frequent lesion color was erythematous (66.7%). Scale and telangiectasia were found in the majority of patients (90% and 66.7%, respectively). The most common histopathological type was Bowenoid, found in 21 cases. This was followed by hypertrophic in 7 cases and pigmented in 2 cases. Seventeen specimens (56.7%) stained positive for PAS and negative for d-PAS. All of the PAS-positive specimens were Bowenoid AK. All specimens stained negative for alcian blue and immunoperoxidase staining results were negative for S-100, HMB 45 and CEA. CONCLUSION: We conclude that clear cells in AK most likely originate due to an accumulation of glycogen or due to hydropic degeneration. The presence of glycogen in clear cells may induce adnexal differentiation to an atypical keratinocyte in AK.
Actins* ; Alcian Blue ; Amylases ; Cheek ; Cytoplasm ; Eosinophils ; Epidermis ; Glycogen ; Humans ; Keratinocytes ; Keratosis, Actinic* ; Telangiectasis

In 1963, Rowell et al. reported a new syndrome characterized by lupus erythematosus with erythema multiforme-like lesions and specific immunological abnormalities, termed Rowell syndrome. Herein, we report a case meeting the criteria for Rowell syndrome. A 30-year-old woman presented with annular, targetoid, erythematous, scaly papules and plaques on her face and the whole body. She also showed abnormal immunoserologic findings. A biopsy specimen confirmed lupus erythematosus and erythema multiforme; therefore, she was diagnosed with Rowell syndrome.
Biopsy ; Erythema ; Erythema Multiforme ; Female ; Humans

BACKGROUND: Weight loss through low-calorie diets (LCDs) decreases visceral fat (VF). However, the effects on muscle mass, changes of dietary quality, and insulin sensitivity are unknown for Korean obese type 2 diabetic subjects. Therefore, this study examined such effects of LCDs. METHODS: A total of 30 obese type 2 diabetic subjects (body mass index, 27.0 +/- 2.2 kg/m2) were randomly assigned to an LCD or control group. Subjects on LCDs took 500~1,000 kcal fewer energy than their usual dietary intake (1,000~1,500 kcal/day) over the course of 12 weeks. The abdominal VF and femoral muscle mass were evaluated by computed tomography, and insulin sensitivity was assessed using an insulin tolerance test (Kitt; rate constant for plasma glucose disappearance, %/min). Dietary nutrient intake consumed by subjects was assessed by 3-day food records. RESULTS: The percent VF reduction was -23.4 +/- 17.2% in the LCD group and -9.8 +/- 11.8% in the control group after 12 weeks (P < 0.001, P = 0.002). However, significant decrease in femoral mass or proportional change of marcronutrient intake and mean adequacy ratio were not found in the LCD group, as compared to the control group. Insulin sensitivity improved in the LCD group, as compared to the control group (P = 0.040). CONCLUSION: LCD effectively improved insulin sensitivity and reduced abdominal VF without reduction of femoral muscle and dietary quality in obese type 2 diabetic subjects.
Caloric Restriction ; Diabetes Mellitus, Type 2 ; Glucose ; Insulin ; Insulin Resistance ; Intra-Abdominal Fat ; Muscles ; Plasma ; Weight Loss

BACKGROUND: Combination fitness regimens (including aerobic and resistance exercises) are effective for improving cardio-respiratory fitness, reducing visceral fat and increasing insulin sensitivity in diabetic patients. The combination exercise intensity that a patient is capable of is limited by his or her aerobic capacity and one repetition maximum (1RM). We investigated the relationships between 1RM, aerobic exercise capacity and body mass index in patients with type 2 diabetes. METHODS: A total of 177 (men: 85, women: 92) diabetic subjects with HbA1c < or = 10% were enrolled. Muscle strength and 1RM were assessed bychest press (upper body) and leg press (lower body). We assessed aerobic capacity by VO2max and muscle mass by bioimpedance analysis. RESULTS: There was no correlation between 1RM and VO2max in type 2 diabetic patients (upper: P = 0.122, lower: P = 0.138 for men, and upper: P = 0.952, lower: P = 0.570 for women). However, 1RM was significantly correlated with muscle mass both in men and women (upper: r = 0.493, P < 0.001, r = 0.315, P = 0.002 lower: r = 0.437 P < 0.001, r = 0.307, P =0.003, respectively). There was also a significant correlation between 1RM and BMI. In obese male subjects with BMI > or = 25 kg/m2, we observed a significant correlation between muscle mass and BMI (r = 0.374, P = 0.032), but this correlation was not observed in women. CONCLUSION: Clinicians treating Korean type 2 diabetic subjects should recommend resistance exercise to their patients. In particular, obese women with diabetes may receive greater benefits by increasing muscle mass through resistance exercises.
Body Mass Index ; Diabetes Mellitus ; Exercise ; Female ; Humans ; Insulin Resistance ; Intra-Abdominal Fat ; Leg ; Male ; Muscle Strength ; Muscles ; Resistance Training