No abstract available.
Leiomyoma*

No abstract available.
Humans ; Schools, Medical*

We looked for and discussed the changes of curricula of medical course of 31 medical schools during the period of 1984 and 1993. The data used in this study were Educational State Report of Korean Med ical Schools published from Dean Association of Korean Medical Schools in 1984 and 1992-1993. The significant findings were as follows. 1. There were great variability in number of subjects and in time for lecture and exercise in each subject among 31 medical schools. 2. There were a great deal of changes during the period of 1984 and 1993. There were increased tendency in number of subjects and especially block lectures. Schools which had 1-4 subjects vanished in curriculum were most frequent among 22 schools during 9 years. Name of most frequent subjects in block lecture were clinico-patholo gical conference, reproductive medicine, hematology, oncology and cardiology in 1993. 3. Subjects which were transferred to pre-medical program were classified to two groups. One group was traditional basic medical subjects such anatomy, physiology and biochemistry, the other group was newly introduced subjects such as molecular biology and cell biology as basic medical subjects. 4. The data were suggested that long time was needed to stabilized in newly introduced subjects of clinical medicine such as neurology and plastic surgery. Time for lecture and exercise of these subjects shows increasing tendency in schools established before 1978, but decreasing tendency in schools established after 1978.
Biochemistry ; Cardiology ; Clinical Medicine ; Curriculum* ; Hematology ; Humans ; Lectures ; Molecular Biology ; Neurology ; Physiology ; Reproductive Medicine ; Schools, Medical ; Surgery, Plastic

We have investigated and discussed the changes of scholarship, tuition and educational facilities in national medical colleges and private medical colleges for the period of 1984 and 1993. The data an alysed in this study were cited from the third edition and the seventh edition and raw data for the eighth edition of the Educational State Report of Korean Medical Schools which were issued by the Deans' Association of Korean Medical Schools. The significant findings were as follows: 1. In all investigated medical college libraries, the number of seats and medical books and the sorts of medical journals have increased, particularly the average budgets for medical journals have increased over 3 times in 1993 compare to 1994. 2. Between 1984 and 1993, total budget for scholarship have been increased out average benefit rate have been decreased from 38.6% to 34.3%. But the average benefit doubled its amount. 3. Average tuition in national medical college was about 52% of that in private medical college in 1993. In national medical colleges, average tuition for premedical course was 10% costly than medical course but it was just opposite to private medical colleges. 4. Between 1984 and 1993, Audio-visual aids have increased in number a little bit but there was nothing significant changes between national and private medical college. 5. Eighty one percent of investigated medical colleges have animal laboratory for research but only 15.6% of medical colleges have specific pathogen free rooms in the animal laboratories. 6. In 1993, the space in medical college buildings was occupied 29.6% by student education facilities, 25.8% by research space for professors and 10.5% by medical library. The average area for student educations was 42.4m2, for professors research was 32.2m2 and for library was 11.4m2 per a student.
Animals ; Audiovisual Aids ; Budgets ; Education ; Fellowships and Scholarships* ; Humans ; Libraries, Medical ; Schools, Medical ; Specific Pathogen-Free Organisms

OBJECTIVE: For the optimal use of antidepressants, it is important to consider the behavioral effects of drugs affecting the real lives of depressed patients, as there is little difference in therapeutic effects between drugs. The aim of this study was to determine the acute pharmacodynamic effects of two recently introduced antidepressants, venlafaxine and mirtazapine, on psychomotor performance, motor activity and daytime sleepiness. METHODS: Twelve healthy male volunteers received a single dose of venlafaxine 37.5 mg, mirtazapine 15 mg or amitriptyline 25 mg (positive control) at one-week intervals in a double-blind, placebo-controlled, crossover design. Volunteers wore an actigraph on their non-dominant wrist for the duration of each test day. A battery of psychomotor tests was performed prior to dosing and at 2 and 6 h post-dose. Subjective daytime sleepiness was also assessed at the end of each test day. RESULTS: Venlafaxine did not affect psychomotor performance, motor activity and daytime sleepiness. Mirtazapine decreased thresholds in critical flicker fusion frequency, increased reaction times in choice reaction tests, and increased peripheral reaction times in compensatory tracking tests. It also caused significant daytime sleepiness and decreased motor activity. CONCLUSION: The differences in the behavioral effect profiles presented in this study should assist in the selection or scheduling of antidepressants.
Amitriptyline ; Antidepressive Agents ; Cross-Over Studies ; Flicker Fusion ; Humans ; Male ; Motor Activity* ; Psychomotor Performance* ; Reaction Time ; Volunteers ; Wrist ; Venlafaxine Hydrochloride

Kawasaki disease (KD) is an acute vasculitis of small and medium sized arteries. Even many years after onset, aneurysms and stenosis in coronary arteries may lead to an acute myocardial infarction, which is described as atypical or missed KD in childhood. KD is an underlying disease of young adults with acute myocardial infarction. We report on a rare case involving a total occlusion in the proximal left anterior descending coronary artery combined with a giant left main aneurysm in a young adult patient with acute myocardial infarction ascribed to antecedent KD that is undefined but almost certain.
Aneurysm* ; Arteries ; Constriction, Pathologic ; Coronary Aneurysm ; Coronary Vessels ; Humans ; Mucocutaneous Lymph Node Syndrome* ; Myocardial Infarction* ; Vasculitis ; Young Adult

BACKGROUND AND OBJECTIVES: Accumulation of keratin debris in the middle ear is one of the characteristics of the cholesteatoma. It is related to increased rate of cell death and differentiation of keratinocytes compare to normal skin. This kind of cell death is known as apoptosis. In this study, we plan to investigate the apoptotic cell death and expression of Fas in both normal and cholesteatoma epithelia. MATERIALS AND METHODS: Seven cholesteatomas and retroauricular skins were obtained from patients undergoing middle ear operations. Detection of the fragmented DNA in apoptosis was done by in situ TUNEL methods and agarose gel electrophoresis. For the morphologic confirmation of apoptosis, transmission electron microscopy (TEM) was done. Immunohistochemistry was also performed for detection of Fas expression on the tissue. RESULTS: In TUNEL staining, many positive staining nuclei were observed in upper layers of cholesteatoma epithelium whereas a few positive cells were found on the granular layer of retroauricular skin. Typical "ladder pattern" was seen on the gel electrophoresis of the genomic DNA of cholesteatoma. On TEM study, we observed condensation of chromatin in the keratinocytes of the cholesteatoma epithelium. Immunohistochemical studies revealed that Fas protein was expressed in all layers of cholesteatoma epithelium, while retroauricular skin showed weak reactions only in the granular layer. CONCLUSION: We confirmed that increased apoptosis and up-regulated expression of Fas in cholesteatoma epithelium. Since Fas is known as apoptosis triggering protein, the authors suggest that accumulation of keratin debris is due to increased apoptotic cell death and further investigation should be needed about the mechanism of cell death in cholesteatoma.
Apoptosis ; Cell Death* ; Cholesteatoma* ; Chromatin ; DNA ; Ear, Middle ; Electrophoresis ; Electrophoresis, Agar Gel ; Epithelium* ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Keratinocytes ; Microscopy, Electron, Transmission ; Skin

No abstract available.

Kawasaki disease (KD) is an acute vasculitis of small and medium sized arteries. Even many years after onset, aneurysms and stenosis in coronary arteries may lead to an acute myocardial infarction, which is described as atypical or missed KD in childhood. KD is an underlying disease of young adults with acute myocardial infarction. We report on a rare case involving a total occlusion in the proximal left anterior descending coronary artery combined with a giant left main aneurysm in a young adult patient with acute myocardial infarction ascribed to antecedent KD that is undefined but almost certain.
Aneurysm ; Arteries ; Constriction, Pathologic ; Coronary Aneurysm ; Coronary Vessels ; Humans ; Mucocutaneous Lymph Node Syndrome ; Myocardial Infarction ; Vasculitis ; Young Adult

Autoimmune hepatitis accompanied by systemic erythematosus lupus is rare. Usually, lupus-related advanced liver involvement is indistinguishable from autoimmune hepatitis accompanied by lupus, as they share common clinical, biochemical, serological, and histological manifestations. However, each disease has its own diagnostic criteria, and they have been defined as two different categories. Therefore, distinguishing between the two diseases is important to determine the correct diagnosis and treatment. A 41-year-old woman was hospitalized with jaundice and a malar rash. The patient met the diagnostic criteria of both systemic erythematosus lupus and autoimmune hepatitis. After corticosteroid treatment, the patient's condition improved. Therefore, we report our experience of a rare case of autoimmune hepatitis accompanied by systemic erythematosus lupus with a review of the literature.
Adult ; Exanthema ; Female ; Hepatitis ; Hepatitis, Autoimmune ; Humans ; Jaundice ; Liver ; Lupus Erythematosus, Systemic