The evolution and different functions of central health administrative organs in different historical periods of China was described in order to fill the gaps in research of their history.

Numerous studies showed that Helicobacter pylori (HP) infection and gastric cancer have a correlation, which is a important factor to influence the development of gastric cancer, with scholars' intensive research, it is found that the way of HP acting on gastric cancer is complicated and diverse, this review summarizes the role of HP in mechanism, correlation factor and action way of gastric cancer.

Objective To explore the effect of pre-operation intestinal preparation by orally taking magnesium sulfate of different concentrations. Methods 50 patients were divided into the high-concentration group and the low - concentration group, according to the concentration of magnesium sulfate orally taken for pre-operation intestinal preparation. Some factors were compared between the two groups including: the acting amount of water, starting and lasting timing of magnesium sulfate, times of stool, the efficiency of the intestinal preparation, the tolerance, uncomfortable reaction and changes of serum electrolyte of the patients. Results There were no difference between the two groups on the acting amount of water, starting and lasting timing of magnesium sulfate, times of stool, the efficiency of the intestinal preparation, the tolerance of the patients. The rate of the stool without solid substance was higher in the high-concentration group than the low-concentration group(40% vs 8%). The uncomfortable reaction rate was also higher in the high-concentration group, the concentration of serum electrolyte decreased in both groups, among which serum Ca2+ decreased significantly in the low-concentration group. Conclusions Orally taking magnesium sulfate of different concentrations both has effect on bowel preparation, influence on patients' serum electrolyte is remarkable.

OBJECTIVE:To establish a method for determination of ionization equilibrium constant of sildenafil using ultraviolet spectrophotometry.METHODS:Methanol solutions of sildenafil with pH values of 2.26,8.56,9.31,9.83 and 12.38 were respectively scanned at the wavelength within the range of 200nm～400nm.The absorbability and pKa value of sildenafil were determined at the selected wavelength of 280,287,290,295 and 297nm respectively.RESULTS:The pKa value of sildenafil was 9.35?0.02.CONCLUSION:The present method is convenient and practicable.

【Objective】To observe the influence of hot-needle therapy and herbal medicine fuming-washing combined with western medicine for the treatment of rheumatoid arthritis(RA).【Methods】One hundred and twenty-eight RA patients were equally randomized into two groups: group A received hot-needle therapy and herbal medicine fuming-washing combined with western medicine of meloxicam,salazosulfamide,and methotrexate,and group B was treated with western medicine only.The treatment lasted one month.Symptoms and signs of early morning stiffness time,grip strength,joints with tenderness count,tenderness index,auricular rest pain,swollen joints count,swelling index as well as the evaluation by the patients themselves and the doctors were observed before and after treatment.Meanwhile,the changes of rheumatoid factor(RF),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),the white blood cell(WBC) count and platelet(PLT) count were evaluated before and after treatment.【Results】The total effective rate in group A was 78.1%,which was superior to 53.1% in group B(P

Penile erection (PE) is a physiological phenomenon involving complex mechanisms. PE may occur as reactive erections, psychogenic erections in the conscious state and spontaneous erections during the sleep. Sleep-related PE refers to the erections occurring spontaneously during the sleep with rapid eye movement. Studies have shown a correlation between sleep and PE as well as between sleep disorders and erectile dysfunction but not yet revealed the exact mechanisms. This paper updates the relationship between sleep and erectile function.
Erectile Dysfunction ; etiology ; Humans ; Male ; Penile Erection ; physiology ; Sleep ; physiology ; Sleep Wake Disorders ; complications ; Sleep, REM ; physiology

Objective To evaluate the effectiveness of a newly designed modular flexible ureteroscope with holmium laser lithotripsy for the treatment of renal calculi based. Methods 40 patients were treated with modular flexible ureteroscopic lithotripsy (German Polydiagnost) with holmium laser. 40 patients were treated by traditional flexible ureteroscopic lithotripsy. Their therapeutic effects were compared. Results For modular flexible ureteroscopic lithotripsy group, 37 patients underwent successful operation, with lithotripsy with operation time of (86.0 ± 34.4) min and postoperative hospital stay of (5.3 ± 1.6) days. No severe complication including ureteral perforation, high fever or severe bleeding occurred. One month after the operation, KUB and B-ultrasonography showed complete stone free in 35 patients. Residual calculi (0. 4 cm in diameter) in the calyces were found in 2 patients. Medication and postural drainage therapy were applied. Two weeks later , KUB and B-ultrasonography showed that the residual stones have been removed completely. There was no significant differences in stone size , operation time, rate of calculus clearance, the incidence of postoperative complications, operating time and duration of postoperative hospitalization between the traditional flexible ureteroscopic lithotripsy group and modular ureteroscopic lithotripsy group. Conclusions The modular flexible ureteroscope is effective and safe in treating reanl calculi. It has similar surgical efficacy as traditional flexible ureteroscope , but is more costly effective in terms of maintenance costs.

Objective Study the inhibitory action of gastric H~+/K~+-ATPase by scopaparia dulcis,extractive from ethanol.Methods measure the gastric H~+/K~+-ATPase activity by animal test and inorganic phosphorus measurement method.Results chemical estimation shows the H~+/K~+-ATPase activity of experiment group is lower than that of control group,there is remarkable difference in statistics.Conclusion the scopaparia dulcis'extractive from ethanol can inhibit the rats' gastric H~+/K~+-ATPase activity.

Objective To explore the diagnosis and treatment rule of eczema by Zhuang Guokang. Methods Data of 58 eczema patients treated by Zhuang Guokang were collected as research objects to set up the database. Support vector machine (SVM) method was adopted to take data mining research of the key points of syndrome differentiation and the rule of medication. Results The nourishing Yin method was extracted as the category property to get 3 classification models of the syndrome differentiation key points, the related treatment methods and medication rule and 63 relevant quantitative data. The accuracy rate of model classification of the main differentiation points of nourishing Yin method corresponding to Yin reached 77.586%, and Kappa value was 0.536. Among these points, the weight of chapping(1.558), papules(1.456), thready pulse(1.036)and desquamation(0.858) got higher significance. The accuracy rate of model classification of medication feature reached 86.2069%, and Kappa value was 0.719. Among these medicines, Pseudostellaria heterophylla(0.776), Semen plantaginis (0.550), Asparagus root(0.525) and Solomonseal (0.388) got higher significance. Conclusion The research revealed the syndrome differentiation key points and the medication rule of Zhuang Guokang’snourishing Yin methodin the treatment of eczema, and explored the path of experience transforming to knowledge of the famous old TCM doctors.

The imbalance between histone acetylation and histone deacetylation can lead to the inactivation of suppressor genes and the activation of oncogenes by influencing transcription. Based on this, researchers found that HDAC inhibitors can induce prostate cancer cells growth arrest, differentiation and apoptosis. This review summarizes the advance research of histone deacetylase inhibitors in treatment of prostate cancer.