1.Design and Implementation of Bluetooth wireless management and monitoring system
Chinese Medical Equipment Journal 2004;0(08):-
This paper introduces the design and implementation of Bluetooth wireless management and monitoring system. Combined with hospital information system, this system replaces the current monitoring system in hospital, and thus the efficiency of hospital can be improved.
2.Clinical efficacy of Simo Tang on functional dyspepsia with syndrome of incoordination between the liver and spleen and its effect on motilin and substance P in plasma
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(06):-
0.05). However,Simo Decoction can ameliorate the symptoms,such as epigastric pain,early satiety,etc.,better than Domperidone tablets(P
3.Progress in the pathogenesis of Henoch-Schonlein purpura
International Journal of Pediatrics 2010;37(1):39-41
Henoch-Schonlein purpura(HSP) is one of the most common blood capillary allergic disorder in children, and its pathogenesis has not been well explained. The studies show that the main mechanism of HSP is the abnormality of humoral immunity, and the role of IgA is emphaszed. Meanwhile, many agents such as changes in T cell function,participation of cytokine and mediators of intlammation, suscepti-bility gene and other factors also play an important role in the incidence of HSP. The pathogenesis of HSP can be better understood through extensive analysis of the immunology factors,genetic factors,and so on.
4.A new target in non-small cell lung cancer: ROS1 fusion gene.
Chinese Journal of Oncology 2013;35(1):1-4
Antigens, Differentiation, B-Lymphocyte
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genetics
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Carcinoma, Non-Small-Cell Lung
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drug therapy
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genetics
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metabolism
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Gene Fusion
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Gene Rearrangement
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Histocompatibility Antigens Class II
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genetics
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Humans
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Immunohistochemistry
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In Situ Hybridization, Fluorescence
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Lung Neoplasms
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drug therapy
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genetics
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metabolism
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Protein Kinase Inhibitors
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therapeutic use
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Protein-Tyrosine Kinases
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antagonists & inhibitors
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genetics
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metabolism
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Proto-Oncogene Proteins
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antagonists & inhibitors
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genetics
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metabolism
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Pyrazoles
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therapeutic use
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Pyridines
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therapeutic use
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Reverse Transcriptase Polymerase Chain Reaction
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Signal Transduction
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Sodium-Phosphate Cotransporter Proteins, Type IIb
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genetics
6.Study of association between interstitial Cells of cajal in bile duct and drug-induced intrahepatic cholestasis
Jia CAI ; Shujun ZHANG ; Bo QIN
Chongqing Medicine 2015;(3):306-308,311
Objective To study the effect of emodin on biochemical indicators of drug‐induced intrahepatic cholestasis model and the interstitial cells of cajal (ICC) in bile duct and to explore the role of ICC and emodin in intrahepatic cholestasis .Methods Fif‐teen rats were randomly divided into drug‐induced intrahepatic cholestasis group ,emodin intervention group and control group(n=5) .Rat cholestatic hepatitis model and emodin intervention model were established .RT‐PCR and immunohistochemistry were used to detect liver function ,c‐kit mRNA and protein expression levels in drug‐induced intrahepatic cholestasis group ,emodin interven‐tion group and control group .Results The degree of liver dysfunction and bilirubin level in drug‐induced intrahepatic cholestasis group were significantly higher than those in control group(P<0 .05);the above indicators in emodin intervention group were sig‐nificantly higher than those in control group but lower than those in drug‐induced intrahepatic cholestasis group(P<0 .05) .The c‐kit mRNA expression located at 548 bp was observed in control group ,emodin intervention group and drug‐induced intrahepatic cholestasis group .Relative expression level of c‐kit mRNA in drug‐induced intrahepatic cholestasis group was significantly lower than that in emodin intervention group and control group (P<0 .05) .Meanwhile ,there was no significant difference in relative ex‐pression level of c‐kit mRNA between emodin intervention group and control group (P>0 .05) .Immunohistochemistry results indi‐cated that expression of c‐kit in drug‐induced intrahepatic cholestasis group was significantly lower than those in control group and emodin intervention group(P<0 .05) .Conclusion There may be close relationship between the forming process of drug‐induced in‐trahepatic cholestasis and decrease of ICC in bile duct .The therapeutic effect of emodin on intrahepatic cholestasis may be related with the number of ICC in bile duct or the positive effect on ICC.
7.Effect of transfected tissue inhibitor of metalloproteinase-2 on nuclear factor-?B and protein kinase C of the injured rabbit vascular smooth cells
Chinese Journal of Trauma 1993;0(05):-
Objective To study the expression changes of matrix metalloproteinases (MMPs), protein kinase C (PKC) and nuclear factor-?B (NF-?B ) on the injured rabbit vascular smooth muscular cells (VSMC) transfected with tissue inhibitor of metalloproteinase-2 (TIMP-2) vector. Methods Lipofectin method was used to transfect TIMP-2 vector into VSMC, Western blot analysis to detect TIMP-2 peptides and zymography assay to determine MMPs. The activities of MMPs and NF-?B were detected by electrophoretic mobility shift assay (EMSA). The mRNA and protein expressions of PKC? were determined by RT-PCR and immunocytochemistry. Results The injured VSMC showed increased enzyme activity of MMP-2. There was very lower level expressions of PKC? and NF-?B in the normal VSMC but high in the injured VSMC. However, in injured VSMC transfected with TIMP-2 vector, the activity of MMP2/9 was suppressed and the expressions of PKC? and NF-?B decreased (P
8.Influence of parental age at delivery and birth order on ankylosing spondylitis
Bo YANG ; Xinghai HAN ; Qing CAI
Academic Journal of Second Military Medical University 2000;0(08):-
2 in B27 positive groups and X = l. 58
9.Primary ureteral carcinoma: MRI diagnosis and comparison with other diagnostic imaging facilities
Ningyu AN ; Bo JIANG ; Youquan CAI ; Yan LIANG
Chinese Journal of Radiology 2001;0(08):-
Objective To investigate MRI examination methods and imaging manifestations of primary ureteral carcinoma, and to evaluate its clinical values when comparing with other diagnostic imaging facilities. Methods Eighty-seven cases of primary ureteral carcinoma who were operated within recent 8 years came into the study, among which, 35 cases had MRI examinations. For MRI examination, coronal heavy T2WI (water imaging) was performed to show the dilated ureter, then axial T2WI and T1WI were scanned at the obstruction level. 11 cases underwent additional Gd-DTPA dynamic contrast enhanced scans. The original pre-operative diagnostic reports of various imaging facilities were analyzed comparing with the results of operation and pathology. Results MRI showed ureteral dilatation in 33 of 35 cases, no abnormal appearance in 1 case, and only primary kidney atrophy post renal transplantation in 1 case. Among the 33 cases with ureteral obstruction, soft mass at the obstruction level was detected on axial scans in 32 cases. The lesions showed gradual and homogeneous mild to moderate enhancement on contrast MRI. The overall employment rate of imaging facilities was as follows: ultrasound (94. 3% ) , IVU (59. 8% ) , CT (52. 9% ) , MRI (40. 2% ) , and RUP (35. 6% ). The accurate diagnostic rate was as follows: MRI (91. 4% ) , RUP (80. 6% ) , CT (63. 0% ) , ultrasound (47. 6% ) , and IVU (11. 5% ). Conclusion Combination of MR water imaging and conventional sequences can demonstrate most primary ureteral carcinoma lesions and has a highest diagnostic accuracy among the current diagnostic imaging facilities. It should be taken as the first diagnostic imaging method of choice when primary ureteral carcinoma is suspected after ultrasound screening.
10.Visfatin and metabolic syndrome
Bo PAN ; Ning LIN ; Donglian CAI
Parenteral & Enteral Nutrition 1997;0(01):-
Obesity-related diabetes and the metabolic syndrome are significantly related to increased adipose tissue mass.Understanding of the effect of adipose tissue on the metabolic regulation will play a key role in therapeutic strategies aimed to reduce obesity-induced insulin resistance and alleviate symptoms of the metabolic syndrome.Visfatin is a novel adipokine that appears to be preferentially produced by visceral adipose tissue and has insulin-mimetic actions.We discusse the relationship between visfatin and metabolic syndrome as well as future therapeutic strategies to these diseases.