No abstract available.
Chorion* ; Chorionic Villi Sampling* ; Chorionic Villi* ; Female ; Pregnancy

Eosinophilic granuloma of the lung, first described by Farrinaci et al. in 1951, is rare. A 35-year-old male smoker presented with recurrent pneumothorax. Open thoracotomy with bleb resection and biopsy was performed. Microscopically there was histological changes consistent with typical eosinophilic granuloma and intertitial fibrosis. The Langerhans cells showed positive reaction for S-100 protein and typical Birbeck granules in their cytoplasm. A brief summary of histopathological aspect of this disease and a review of literature are presented.
Male ; Humans ; Biopsy

No abstract available.

PURPOSE: To report a case of a young man with nonspecific normal retinal vessels found in foveal avascular zone. METHODS: We experienced a 20-year-old man with decreased visual acuity of left eye. In anterior segment there was no abnormality, but there were unusual vessels in foveal avascular zone that appeared to be normal vessels. RESULTS: In fluorescein angiography, dye was exhibited on the vessel of foveal avascular zone in 14-15 sec after injection, and there were no leaking or abnormal findings. CONCLUSIONS: Normal retinal vasculature in foveal avascular zone is known to be an extremely unusual case in normal adult, and it is to report a case with review of available papers.
Adult ; Fluorescein Angiography ; Humans ; Retinal Vessels* ; Retinaldehyde* ; Visual Acuity ; Young Adult

OBJECTIVE: To compare COH characteristics and IVF outcomes among IVF-ET patients who were treated with various therapeutic modalities for ovarian endometriomas and to propose effective pre-cyclic therapeutic modalities to improve IVF-ET outcomes in the patients with ovarian endometriomas. METHODS: All cases that had undergone IVF-ET after laparoscopy between January 1997 to August 2003 were reviewed. Forty-eight patients with tubal factor were assigned to Group I. Twenty seven, 22 and 38 patients diagnosed as severe pelvic adhesion with ovarian endometriomas by laparoscopy received only medical therapy (Group II), cyst aspiration (Group III), and sclerotherapy (Group IV), respectively. Laparoscopic cystectomy was performed in 20 patients (Group V). Resistance index was measured on day administering hCG. RESULTS: As compared with Group I, in Group II resistance index increased (p<0.05) but number of oocytes, good-quality oocyte ratio (mature and intermediate oocytes/total retrieval oocytes), fertilization rate, and embryo development rate decreased (p<0.05). In Group III fertilization rate and embryo development rate decreased (p<0.05). There was no difference between Group IV and Group I in all parameters except basal FSH which increased (p<0.05). In Group V basal FSH, and resistance increased (p<0.05) and number of oocytes and good-quality oocytes ratio decreased (p<0.05). CONCLUSION: Sclerotherapy is an effective therapeutic option which can be done prior to IVF-ET cycles in the patients with ovarian endometriomas. Further studies on a large scale are necessary to confirm these data.
Cystectomy ; Embryonic Development ; Endometriosis* ; Female ; Fertilization ; Humans ; Laparoscopy ; Oocytes ; Pregnancy ; Sclerotherapy

Hemoglobin M (HbM) is a group of abnormal hemoglobin variants that form methemoglobin, which leads to cyanosis and hemolytic anemia. HbM-Milwaukee-2 is a rare variant caused by the point mutation CAC>TAC on codon 93 of the hemoglobin subunit beta (HBB) gene, resulting in the replacement of histidine by tyrosine. We here report the first Korean family with HbM-Milwaukee-2, whose diagnosis was confirmed by gene sequencing. A high index of suspicion for this rare Hb variant is necessary in a patient presenting with cyanosis since childhood, along with methemoglobinemia and a family history of cyanosis.

Ulcerative colitis is a chronic inflammatory disorder causing mucosal inflammation of the colorectum with crypt abnormality on biopsy. It affects the rectum and a variable extent of the colon in continuity. Ulcerative colitis is characterized by a relapsing and remitting course. It arises from an interaction between genetic and environmental factors, but the precise etiology is unknown. The incidence and prevalence in Korea are still low compared with those of Western countries, but have increased in recent years. There are many challenging issues on the diagnosis of ulcerative colitis, and sometimes these lead to differences in practice between clinicians. Therefore, IBD Study Group of KASID set out the Korean diagnostic guideline of ulcerative colitis. The diagnosis is based on clinical, endoscopic, radiologic, and histologic criteria. The symptoms are dependent upon the extent and severity of disease and most commonly include bloody diarrhea, rectal bleeding, and/or urgency. The systemic symptoms of malaise, tachycardia, fever, or weight loss are features of a severe attack. The laboratory findings may reveal leucocytosis, thrombocytosis, iron deficiency anemia, hypoalbuminemia, and elevated erythrocyte sedimentation rate and C-reactive protein indicating severe disease activity or chronicity. For the elimination of infectious causes, microbial investigation with stool specimens should be performed for common enteric pathogens including assays for Clostridium difficile toxin, and sometimes for amoeba or other parasites. The most typical endoscopic features are continuous, confluent, and concentric colonic involvement proximal to the anal verge. Endoscopic severity may be best well reflected by the presence of mucosal friability, spontaneous bleeding, and deep ulcerations. Typical pathologic findings are composed of widespread crypt architectural distortion (cryptitis, crypt abscess, and crypt atrophy), heavy, diffuse lamina propria cell infiltration, and basal plasmacytosis.
Blood Chemical Analysis ; Colitis, Ulcerative/*diagnosis/epidemiology/pathology ; Colonoscopy ; Diagnostic Imaging ; Hematologic Tests ; Humans ; Severity of Illness Index

In this study, we investigated the effects of a selective urotensin II (UII) receptor antagonist, SB-657510, on the inflammatory response induced by UII in human umbilical vein endothelial cells (EA.hy926) and human monocytes (U937). UII induced inflammatory activation of endothelial cells through expression of proinflammatory cytokines (IL-1beta and IL-6), adhesion molecules (VCAM-1), and tissue factor (TF), which facilitates the adhesion of monocytes to EA.hy926 cells. Treatment with SB-657510 significantly inhibited UII-induced expression of IL-1beta, IL-6, and VCAM-1 in EA.hy926 cells. Further, SB-657510 dramatically blocked the UII-induced increase in adhesion between U937 and EA.hy926 cells. In addition, SB-657510 remarkably reduced UII-induced expression of TF in EA.hy926 cells. Taken together, our results demonstrate that the UII antagonist SB-657510 decreases the progression of inflammation induced by UII in endothelial cells.
Cytokines ; Endothelial Cells* ; Human Umbilical Vein Endothelial Cells ; Humans* ; Inflammation ; Interleukin-6 ; Monocytes ; Thromboplastin ; Vascular Cell Adhesion Molecule-1

BACKGROUND AND OBJECTIVES: Concha bullosa is one of the most common obstructive anatomical variants seen in patients with sinusitis. We wanted to illustrate the relationship of the contents and CT findings of concha bullosa, and of the contents of concha bullosa and the lesion at the origin site of concha bullosa. MATERIAL AND METHODS: We evaluated PNS CT of 1023 patients with sinusitis, and a total of 172 patients with concha bullosa were evaluated to study the contents and origin site of concha bullosa by CT and endoscopic findings and pathologic confirmation of the contents. RESULTS: Contents of the concha bullosa were normal mucosa in 29.2%, mucosal thickening 26.0%, mucopurulent discharge 35.6% and polyp 9.2%. Although CT findings and the origin site of concha bullosa were normal, the diseased concha bullosa were 30.1% and 23.0%. CONCLUSION: Regardless to the presence of disease at the origin site and CT findings of Concha bullosa, we found it necessary to validate concha bullosa.
Humans ; Mucous Membrane ; Polyps ; Sinusitis

BACKGROUND AND OBJECTIVES: Endoscopic sinus surgery has recently become a popular and effective treatment method for chronic paranasal sinusitis. Although several papers have been written about the results of ESS, little has appeared about its longterm results. The purpose of this study is therefore to add to the understanding long-terms results of EES by presenting our experience. MATERIAL AND METHODS: We report our experience on 410 patients who underwent endoscopic sinus surgery for chronic paranasal sinusitis from January 1993 to August 1995 and a long term follow-up study from 12 to 36 months. We evaluated their preoperative symptoms, previous nasal surgery history, anatomical variations on the preoperative OMU-CT, pattern of inflammatory sinonasal disease, as well as their postoperative improvement of the symptoms using questionnaires and the endoscopic sinonasal findings. RESULTS: Nasal obstruction was the most improved symptom. Patients without any history of nasal surgery had relatively good results compared to those with previous operation history. Patients with an OMU anatomical variation also had relatively good results compared to those with no OMU variation. Among the different patterns of chronic paranasal sinusitis based on the Babbel classification, the sinonasal polyposis pattern (IV) showed most inferior postoperative improvement of the symptoms. Nevertheless, the overall postoperative improvement of chronic paranasal sinusitis indicates that the endoscopic sinonasal surgery was effective. CONCLUSION: On the whole, 371 (91%) of the 410 patients benefited from this procedure, indicating that endoscopic sinus surgery provides an efficient method for treating chronic sinusitis and that sinonasal polyposis can be managed with a high level of success.
Classification ; Follow-Up Studies ; Humans ; Nasal Obstruction ; Nasal Surgical Procedures ; Surveys and Questionnaires ; Sinusitis*