The aircraft industry is crucial to the economy and security of a nation. In this paper, the spatial characteristics and patterns of the aircraft industry are analyzed on different spatial scales. It is found that there is a 'Matthew effect' in the global aircraft industry and the spatial evolution of the industry is consistent with the industrialization process of the whole country. It is also revealed that the spatial evolution of the country is driven by both the centripetal forces including capital, talents, technology and agglomeration economies and the centrifugal forces including the comparative advantage, cost &risk sharing, emerging markets, development policy for less-developed regions and the military imperative. These forces have both market-stabilizing and market-disrupting effects on the spatial evolution of the aircraft industry. The study suggests that lessons drawn from the experiences in the United States and France are expected to be conducive to the rise of China's aircraft industry in the future.

As a new learning method,mind map presents learning materials in a visual,radical and non-linear way.Application of mind map in teaching of pathophysiology could help teachers get the thread of textbook,enhance students'motivation for learning,help students get the main points and improve their efficiency.Mind map could make students think in a way of problem-based learning,and its advantage in training up divergent thinking could also develop students'innovation ability.

Following the medical discipline’s own developmental pattern,according to the intrinsic requirement of the university’s construction,the edge disciplines which are the medicine and the humanities overlapping,and relatively superior should be developed by high starting point,specialization and the key breakthrough way.Considering the multidisciplinary development on the construction and developmental strategic altitude of the academy by following the development regularity of different subject itself,by consummating the leadership mechanism,transforming management conceptions,concising discipline direction,strengthening construction of the talented person troop and so on,is the inevitable choice of the related disciplines development in the provincial medical academy

MicroRNA(miRNA) is a class of small noncoding RNA molecules that regulate gene expression by functioning as a post-transcriptional regulatory factor basing on pairing with target mRNA,leading to mRNA cleavage or translation repression,and playing an important role in several fundamental biological and pathological processes.Consequently,nearly every biological process is related to miRNA.MicroRNA-21 is a typical miRNA,which has been found in recent years.It has been shown to participate in the development and prognosis of the pathogenesis of acute kidney injury,IgA nephropathy,renal cell carcinoma and other renal disea ses.Therefore,microRNA-21 may be a new target for the treatment of these diseases in the future.This paper reviews the correlative literature and research development regarding the roles of microRNA-21 in kidney disease,and providing references for diagnosis and treatment of kidney disease in the future.

Objective To explore the clinical effect of precise radiotherapy combined with gefitinib in the treatment of elderly patients with locally advanced non -small cell lung cancer. Methods 88 cases with locally advanced non small cell lung cancer patients treated from December 2014 to January 2016 in Shanxi Cancer hospital were randomly divided into control group and study group (n=44) by random number table method, the control group received radiotherapy, the study group on precise radiotherapy given gefitinib oral treatment, clinical intervention for 3 months evaluation of clinical efficacy of the two groups, the levels of serum tumor markers (CEA, CA125, CA242) in the two groups were compared before and after the intervention, and the incidence of adverse drug reactions was observed and compared. Results The control rate of the study group and the control group were 90.91％ and 72.72％ respectively, the difference was statistically significant (P<0.05). After treatment, the levels of CEA, CA125 and CA242 in the two groups were significantly lower than those in the control group (P<0.05). The level of CEA, CA125 and CA242 in the study group was significantly lower than that in the control group (P<0.05), after treatment the study group decreased more significant than the control group (P<0.05). The study group and the control group had adverse adverse reaction rates were 34.14％ and 27.27％, and rank sum test the research group VS control group (Z=0.657, P=0.511), there was no significant difference between the two groups. Conclusion Precise radiotherapy combined with gefitinib in the elderly patients with locally advanced NSCLC treatment is a safe treatment method, can effectively improve the clinical efficacy, improve the level of serum tumor markers, it is worthy of clinical application.

Objective To discuss the clinical effects of enteral immunonutrition on patients with hyperlipidemic acute pancreatitis and its influence on levels of immunologic function and nutrition indicators.Methods 2015,100 patients with hyperlipidemic acute pancreatitis Selected from department of general surgery between January 2012 and December were randomly divided into observation group and control group,and each group had 50 cases.All patients were treated with conventional treatment,monitored for vital signs,fasting water,gastrointestinal decompression,anti-infection,acid suppression therapy and suppression of trypsin activity,balance of water electrolyte and acid-basewere included.After bowel function in patients with recovery,two groups were given enteral nutrition support,observation group were received enteral immunonutrition therapy.At the same time,we added the immune enhancement components.After treatment for 10 days,we compare two groups of patients with therapeutic effect,for APACHE-Ⅱ score,nutrition indicators (ALB,PAB),immune index(TLC,IgA,IgG,IgM) changes.Results After two groups of patients were given different enteral nutrient solution,the clinical total effective rate of observation group was obviously higher than that of control group(P ＜ 0.05).After treatment for 10 days,the indicators were obviously improved.The APACHE-Ⅱ score of the observation group were significantly fallinger than that of the control group (t =3.311,P ＜0.05).The ALB and PAB levels of the observation group were significantly higher than those of the control group (t =2.217,6.622,P ＜ 0.05).At the same time,the TLC,IgA,IgG,IgM of the observation group were improved significantly better than the control group (t =3.600,4.867,3.270,3.911,P ＜ 0.05).Conclusion Enteral immunonutrition can improve the nutrition indicators and immunological function of patients with hyperlipidemic acute pancreatitis,thus improve prognosis and promoting recovery of the patient.

Objective To explore the clinicopathologic features and surgicalResultsof paraaortic node-positive periampullary adenocarcinoma. Methods101 patients underwent pancreatectomy with regional and paraaortic lymphadenectomy.Fifteen(15%)patients had histologically proven paraaortic lymph node disease. ResultsThe 15 patients included 9(26%)of 34 patients with pancreatic head carcinoma and 6(17%)of 36 patients with bile duct adenocarcinoma.All 15 patients had locally advanced tumor invading adjacent structures.The 1-,2-,and 3-year survival rates were 33%,27%,and 0%,with median survival of 12 months(range from 3 to 33months).In patients with pancreatic head carcinoma or bile duct adenocarcinoma,survival curve for those without paranortic lymph node metastasis was significantly better than those with involved paraaortic lymph nodes(P＜0.01). ConclusionWhen the paraaortic lymph nodes obtained from sampling biopsy were histologically positive,radical pancreatectomy with extended lymphatic and soft tissue clearance should be abandoned owing to poor outcome.

Systemic review of all the relevant randomized controlled trials (RCTs) was performed. RCTs were identifiedfrom Cochrane Library, MEDLINE, EMBASE. Limited evidence showed that problem-based learning in continuingmedical education increased participants' knowledge, performance and patients' health. Moderate evidence also showedthat doctors are more satisfied with problem-based learning. Problem-based learning may work in continuing medicaleducation, however,the evidence is too weak to be recommended. Rigorously large sample, well-designed randomizedcontrolled trials are required.[

Based on analyzing problems that traditional medical eduction mode faces,the author puts forward the construction of education mode of evidence-based medicine in medical students. And at the same time ,the article also makes research and discussion in relation to the following aspects: how to introduce evidence-base medicine into medical education; how to effectively implement teaching of evidence-based medicine.