Objective To explore the clinical efficacy and safety of pituitrin and phentolamine in the treatment of senile bronchiectasis with massive hemoptysis,thus to provide guidance for the clinical.Methods 80 elderly patients were selected as the subjects of this experiment,and the patients were randomly divided into two groups using the envelope random grouping method.40 patients in the control group used phentolamine.40 cases in the observation group were treated with pituitrin and phentolamine.The clinical curative effect,bleeding time,bleeding volume and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 92.50％,which was significantly higher than 70.00％ of the control group (x2 =6.646,P ＜ 0.05).The bleeding time,total amount of bleeding of the observation group were significantly less than those of the control group (tbleeding time =5.069,tbleeding volurne =5.447,all P ＜ 0.05).The incidence rate of adverse reaction in the observation group was 7.50％,which was significantly lower than 27.50％ of the control group (x2 =5.541,P ＜ 0.05).Conclusion Phentolamine combined with pituitrin in the treatment of senile bronchiectasis with massive hemoptysis can significantly relieve symptoms,shorten the bleeding time,reduce the total amount of bleeding,reduce the probability of adverse reactions in patients.

Objective To explore the clinical effect of precise radiotherapy combined with gefitinib in the treatment of elderly patients with locally advanced non -small cell lung cancer. Methods 88 cases with locally advanced non small cell lung cancer patients treated from December 2014 to January 2016 in Shanxi Cancer hospital were randomly divided into control group and study group (n=44) by random number table method, the control group received radiotherapy, the study group on precise radiotherapy given gefitinib oral treatment, clinical intervention for 3 months evaluation of clinical efficacy of the two groups, the levels of serum tumor markers (CEA, CA125, CA242) in the two groups were compared before and after the intervention, and the incidence of adverse drug reactions was observed and compared. Results The control rate of the study group and the control group were 90.91％ and 72.72％ respectively, the difference was statistically significant (P<0.05). After treatment, the levels of CEA, CA125 and CA242 in the two groups were significantly lower than those in the control group (P<0.05). The level of CEA, CA125 and CA242 in the study group was significantly lower than that in the control group (P<0.05), after treatment the study group decreased more significant than the control group (P<0.05). The study group and the control group had adverse adverse reaction rates were 34.14％ and 27.27％, and rank sum test the research group VS control group (Z=0.657, P=0.511), there was no significant difference between the two groups. Conclusion Precise radiotherapy combined with gefitinib in the elderly patients with locally advanced NSCLC treatment is a safe treatment method, can effectively improve the clinical efficacy, improve the level of serum tumor markers, it is worthy of clinical application.

In order to study the significance of FasL expression in immune escape of breast cancer, FasL protein expression and the number of tumor-infiltrating lymphocytes (TILs) in 40 specimens of breast cancer were detected by immunohistochemitry. The expression of FasL mRNA was measured by in situ hybridization in the consecutive tissue slices of 40 breast cancers respectively. By using terminal deoxynucleotidyl transferase-mediaed dUTP nick end labeling (TUNEL), apoptotic cells were detected in 40 specimens of breast cancer. The expression of FasL was detected in all 40 specimens to varying degrees. In the consecutive tissue slices, the location of expression of FasL protein corresponded with that of FasL mRNA. In those with FasL extensive expression, the number of TILs was less (P<0.05), the apoptotic index (AI) of TILs was higher and the AI of tumor cells was lower (P<0.01) than those with FasL weak expression respectively. The AI of TILs was correlated with that of tumor cells (r= -0.629, P<0.01). In conclusion, breast cancer cells can induce the apoptosis of TILs through the expression of FasL, which can counterattack the immune system. This may be a mechanism of immune evasion in breast cancer.

The researches on ocular dominance have been continuing deeply last decade years since the concept was first described by means by Porta in 1593.Based on the neurophysiology and molecular biology,it is confirmed that the procedure of ocular dominance involves sublayer 4C of the visual cortex,N-Methyl-D-aspartate (NMDA)-receptor,a-calmodulin kinase Ⅱ (aCaMK Ⅱ),synapses and about candidate gens.Meanwhile,ocular dominance theory plays an important guiding role in optometry,laser-assisted in situ keratomileusis and cataract operation.In this review,the mechanism and clinical application of ocular dominance were summarized.

Objective: To investigate the therapeutic value of dual source CT coronary CTA (DSCTA) in coronary atherosclerosis. Methods: Ninety five cases with clinical highly suspected coronary artery disease in DSCTA were selected from January 2013 to December 2014, coronary angiography (CAG) as thegold standard, analysis of DSCTA assessment of coronary artery stenosis and coronary artery display accuracy and consistency of CAG findings. Results: ①CAG inspection coronary artery stenosis with mild, moderate stenosis, severe stenosis were 149, 81, 55, DSCTA accurate assessment of were respectively 140, 79, 54, accuracy rate of 95.79 %, consistency test was statistically significant (Kappa=0.679, P<0.05); ②CAG examination coronary artery branch show: <3, 3-5 branch,>5 were 8 cases, 68 cases, 19 cases, DSCTA were accurately detected in 8 cases, 65 cases, 15 cases, accuracy rate of 92.63%, consistency test was statistically significant(Kappa=0.608, P<0.05). Conclusion:DSCTA in assessing the degree of stenosis of coronary atherosclerosis and coronary branch vessels show areas with good results, worthy of recognition in clinical.

OBJECTIVE To investigate the distribution characteristic and drug resistance status in pathogens isolated from infected urinary tract and offer the scientific evidence for reasonable usage of antibiotics.METHODS Totally 257 strains of pathogens isolated from infected urinary tract were identified by auto-microbiological assay and antibiotic susceptibility test was performed by K-B method.RESULTS Among 257 strains,Escherichia coli accounted for 60.3%,ranking the first.Enterococci ranked the second,accounting for 10.5%.Except for 100% sensitivity to imipenem,meropenem,vancomycin and teicoplanin,the pathogens were resistant to the other antibiotics in different degrees.The detection rate of extended-spectrum beta-lactamases(ESBLs) producers in E.coli and Klebsiella pneumoniae were 40.0% and 37.5%,respectively.CONCLUSIONS The drug resistance of pathogens from infected urinary tract is on the rise.We should strengthen monitoring and controlling of it.

OBJECTIVE To investigate drug-resistance status and changing tendency of Escherichia coli inducing hospital infection to provide the evidence for reasonable use of antibiotics. METHODS Pathogenic bacteria were isolated and identified according to the National Clinical Laboratory Manipulation Rules. Drug resistance profile was analyzed by K-B methods. RESULTS In the four years, the resistance to seventeen common antibiotics in E. coli was on the rise. The resistance rate to ampicillin was the most highest, 90.8-94.2%. There was no strain that was resistant to imipenem and meropenem. Detection rate of extended spectrum ?-lactamases (ESBLs) producing E. coli increased from 13.2% to 32.0%. CONCLUSIONS Drug-resistance status of E. coli inducing hospital infection is very serious. We should strengthen the management of antibiotic use and control the spread and prevalence of the drug-resistant bacteria.

Objective To explore the clinicopathologic features and surgicalResultsof paraaortic node-positive periampullary adenocarcinoma. Methods101 patients underwent pancreatectomy with regional and paraaortic lymphadenectomy.Fifteen(15%)patients had histologically proven paraaortic lymph node disease. ResultsThe 15 patients included 9(26%)of 34 patients with pancreatic head carcinoma and 6(17%)of 36 patients with bile duct adenocarcinoma.All 15 patients had locally advanced tumor invading adjacent structures.The 1-,2-,and 3-year survival rates were 33%,27%,and 0%,with median survival of 12 months(range from 3 to 33months).In patients with pancreatic head carcinoma or bile duct adenocarcinoma,survival curve for those without paranortic lymph node metastasis was significantly better than those with involved paraaortic lymph nodes(P＜0.01). ConclusionWhen the paraaortic lymph nodes obtained from sampling biopsy were histologically positive,radical pancreatectomy with extended lymphatic and soft tissue clearance should be abandoned owing to poor outcome.

8 m. Class Ⅱ: phonation time 6-9 s, and 6-9 syllables; clear pronunciation, fluent expression, audible distance 5 m. Class Ⅲ: phonation time 80 dB was regarded as normal. ③Language diagram: Normal vowels were characterized by sine harmonic wave, even and regular flow mark, clear first and second resonance peaks and little noise in high frequency area above 4 000 Hz. RESULTS: All 60 patients were included in final analysis. ①After professional instruction and training, 39 cases reached the class Ⅰ, 14 reached class Ⅱ, and only 7 was at class Ⅲ. ②The maximum mean sound intensity was 85.5 dB. ③The language diagram characteristics of the patients was similar to healthy persons. The sound energy predominantly located at low and medium frequency areas, and gradually decreased in high frequency area. CONCLUSION: The pneumatic artificial larynx is characterized by simple operation, clear speech, nearly normal sound intensity, tone, and tone color. It is worthy of extensive application in clinic.