In 1982, ADP-ribosylation factors (ARFs), a family of GTP-binding proteins associated with Golgi complexes, were initially recognized based on their ability to stimulate the ADP-ribosyltransferase activity of cholera toxin in vitro, and named so. In fact, this pathophysiologic activity has been useful for functionally defining members of the ARF family. However, during last decade, genetic and biochemical studies have shown the physiologic role of ARFs that also play an essential role in intracellular vesicular transport, particularly in Golgi complexes, activate phospholipase D activity as a nod of signal transduction of cells. Moreover, their more functions were revealed continuously recently. Especially, human ARF1 was found earliest, and studied profoundly in human body cell. Therefore, in this article, there is a comprehensive review about its regulators and effectors, functions and its possibilities involved in tumorigenesis, development of tumors.

Objective: To explore the clinical and magnetic resonance imaging (MRI) features of papillary musclehypertrophic cardiomyopathy. Methods: Our research contained 2 groups: Papillary muscle hypertrophic cardiomyopathy group,n=21 patients treated in our hospital from 2013-01 to 2015-12 including 18 male and 3 female; Control group,n=50 subjects without cardiovascular disease those were conifrmed by our hospital at the same period of time. Clinical and MRI examinations were conducted in all patients, the ifndings were compared between 2 groups. Results: Compared with control subjects, papillary musclehypertrophic cardiomyopathy patients had the main symptoms of shortness of breath, chest tightness and pain; associated with systolic murmur; ECG could be normal or with T wave inversion; cardiac MRI showed that 1/2 papillary muscle diameter>1.1cm. Blood levels of triglyceride, left atrial diameter, inter-ventricular septum thickness, the values of E/A and EDT were statistically different between 2 groups, allP<0.05. Conclusion: Clinical features of papillary muscle hypertrophic cardiomyopathy were lack of speciifcity, the morbidity and clinical signiifcance should be further investigated.

Objective To study the correlation between organizational commitment of nurses and their intention to drop out. Methods Toally 304 contract nurses were recruited in this investigation. The questionnaires including demographic data, scale of organizational commitment and intention to drop out scale were used. Results The score of intention to drop out was 16.94 ± 2.16. The score on organizational commitment was 71.19 ± 6.65. There was a positive correlation between intention to drop out and organizational commitment among the contract nurses. Conclusions Improving contract nurses′organizational commitment can be an effective mean to reduce contract nurses′intention to drop out. It is an important means to promote the development of the nurse team and provide a reference for the scientific development of nursing.

The present situation and the deficiencies of high-value medical consumables were analyzed. Two-dimensional barcode technology was suggested to be involved in the whole-course dynamic tracing of the high-value consumables to combine the high-value consumables information with the patient information. The course included the links of acquisi-tion, warehousing, barcode preparation, delivering and charging. Two-dimensional barcode technology may enhance the medical consumables management and decrease medical dispute, and thus contributes to the development of digital hospi-tal.

Objective To evaluate the the brow position and shape in young Chinese women using a photography measurement.Methods A total of 100 Chinese women aged 20 to 30 years were photographed to determine the distance between brow and eye.Measurements were made from a horizontal plane through the lateral canthus of right eye to three vertical points on the upper brow margin at the medial canthus,lateral limbus of the iris,and lateral canthus.Results The distance between brow and eye in young Chinese women was 2.12,2.52 and 2.46 cm at medial canthus,lateral limbus of the iris and lateral canthus,respectively.The distances were higher between the brows and eyes at lateral limbus of the iris and lateral canthus than that at medial canthus (P＜0.05).Conclusions The measurement used in this study is a simple and practical quantitative method.The results can be used to guide the surgical choice and help to evaluate the surgical techniques.

In this article,a new approach tosleep analysis based on fuzzy prediction theory is described.This article gives a general introduction todetection and processing of biological signals with LabVIEW technique.The designed fuzzy measurement system is applied tofuzzy prediction analysis of physiological signals.The experiment results show that our method of analysis is correct.SoLabVIEW-based fuzzy prediction analysis is more helpful for early diagnosis,monitoring and prognosis assessment of some diseases.The method might reflect the sleep state of SASpatient.

This paper mainly introduces a new method for detection of QT interval in ordinary ECG. As the interval between QRS waves and T wave in ECG, QT interval represents the depolarization of ventricle. QT interval and its aberrance can be used to forecast malignant abnormalities of heart rate. Wavelet transform is a time scale analysis method of the signal. It has a high frequency resolution and a low time resolution for the low-frequency part of the signal, and has a high time resolution and a low frequency resolution for the high-frequency part. On the basis of the characteristics of the starting point of QT interval, the second derivative of Gaussian function is adopted as the wavelet basis and applied to multi-scale transform of ECG signal. The waveforms with QRS waves as starting point and T wave as the end point are selected as the subjects. Then the measurement result is transformed into corrected QT interval, that is, QTC. QTC can be applied to forecasting the diseases.

Telemedicine is the significant object of the medicine in the future. This paper introduces an available counteractive mechanism which is derived from the orthogonal Latin squares, and a modulation method for the data transmission of the telemedicine system is proposed. This method could resolve the problem of overlapping interference from multiple accesses on one channel efficiently. At the same time, it also has potential advantages in increasing the user numbers in one channel and improving the channel utilization.

Objective:To investigate the duck thymocyte surface antigens.Methods:Repeated immunization of normal BALB/c mice with separated thymocyte from mature duck result in the production of mAbs which react with duck thymocyte surface antigens.Applying the immunohistochemistry assay,tracing the originating and distributing of lymphocytes which reacted with mAb in spleen,thymus,and bursa of duck different development stages.Results:Five monoclonal antibody-producing hybridomas(B6,B8,C12,E6,H5)were isolated.According to the result of immunohistochemistry assay,there were distributing strained lymphocytes in thymus,bursa and spleen of duck.The stained cells belonged to different populations.Conclusion:The mAb C12 reacted with the common cell surface marker of between mature T lymphocytes and dendritic cells.

Objective To explore the protective effect of resveratrol on rat brain injury resulting from severe acute pancreatitis (SAP). Methods Ninety-six male Sprague-Dawley rats were randomly divided into four groups:sham-operation (SO) group,severe acute pancreatitis (SAP) group,resveratrol-treated (RES) group and dexamethasone-treated (DEX) group,with eight rats in each group evaluated at 3,6 and 12 h. Levels of serum myelin basic protein (MBP),tight junction protein zonula occludens 1 (Zo-1),TNF-? and IL-6 were determined by ELISA. The ultrastructural changes of the brain and pancreatic tissues were examined using a transmission electron microscope. Results MBP,Zo-1,TNF-? and IL-6 levels in RES group were lower than those in SAP group at all time points (P0.05). Conclusion The degradation of Zo-1 is involved in the pathophysiology of brain injury in SAP; MBP can be used as a marker of brain injury in SAP rats. Resveratrol can inhibit brain injury associated with SAP.