Objective: To explore the clinical and magnetic resonance imaging (MRI) features of papillary musclehypertrophic cardiomyopathy. Methods: Our research contained 2 groups: Papillary muscle hypertrophic cardiomyopathy group,n=21 patients treated in our hospital from 2013-01 to 2015-12 including 18 male and 3 female; Control group,n=50 subjects without cardiovascular disease those were conifrmed by our hospital at the same period of time. Clinical and MRI examinations were conducted in all patients, the ifndings were compared between 2 groups. Results: Compared with control subjects, papillary musclehypertrophic cardiomyopathy patients had the main symptoms of shortness of breath, chest tightness and pain; associated with systolic murmur; ECG could be normal or with T wave inversion; cardiac MRI showed that 1/2 papillary muscle diameter>1.1cm. Blood levels of triglyceride, left atrial diameter, inter-ventricular septum thickness, the values of E/A and EDT were statistically different between 2 groups, allP<0.05. Conclusion: Clinical features of papillary muscle hypertrophic cardiomyopathy were lack of speciifcity, the morbidity and clinical signiifcance should be further investigated.

In 1982, ADP-ribosylation factors (ARFs), a family of GTP-binding proteins associated with Golgi complexes, were initially recognized based on their ability to stimulate the ADP-ribosyltransferase activity of cholera toxin in vitro, and named so. In fact, this pathophysiologic activity has been useful for functionally defining members of the ARF family. However, during last decade, genetic and biochemical studies have shown the physiologic role of ARFs that also play an essential role in intracellular vesicular transport, particularly in Golgi complexes, activate phospholipase D activity as a nod of signal transduction of cells. Moreover, their more functions were revealed continuously recently. Especially, human ARF1 was found earliest, and studied profoundly in human body cell. Therefore, in this article, there is a comprehensive review about its regulators and effectors, functions and its possibilities involved in tumorigenesis, development of tumors.

Objective To study the correlation between organizational commitment of nurses and their intention to drop out. Methods Toally 304 contract nurses were recruited in this investigation. The questionnaires including demographic data, scale of organizational commitment and intention to drop out scale were used. Results The score of intention to drop out was 16.94 ± 2.16. The score on organizational commitment was 71.19 ± 6.65. There was a positive correlation between intention to drop out and organizational commitment among the contract nurses. Conclusions Improving contract nurses′organizational commitment can be an effective mean to reduce contract nurses′intention to drop out. It is an important means to promote the development of the nurse team and provide a reference for the scientific development of nursing.

In this article,a new approach tosleep analysis based on fuzzy prediction theory is described.This article gives a general introduction todetection and processing of biological signals with LabVIEW technique.The designed fuzzy measurement system is applied tofuzzy prediction analysis of physiological signals.The experiment results show that our method of analysis is correct.SoLabVIEW-based fuzzy prediction analysis is more helpful for early diagnosis,monitoring and prognosis assessment of some diseases.The method might reflect the sleep state of SASpatient.

This paper mainly introduces a new method for detection of QT interval in ordinary ECG. As the interval between QRS waves and T wave in ECG, QT interval represents the depolarization of ventricle. QT interval and its aberrance can be used to forecast malignant abnormalities of heart rate. Wavelet transform is a time scale analysis method of the signal. It has a high frequency resolution and a low time resolution for the low-frequency part of the signal, and has a high time resolution and a low frequency resolution for the high-frequency part. On the basis of the characteristics of the starting point of QT interval, the second derivative of Gaussian function is adopted as the wavelet basis and applied to multi-scale transform of ECG signal. The waveforms with QRS waves as starting point and T wave as the end point are selected as the subjects. Then the measurement result is transformed into corrected QT interval, that is, QTC. QTC can be applied to forecasting the diseases.

Objective To investigate the CT and MRI features of levamisole induced encephalopathy. Methods The CT and MRI features of 6 cases with clinically proven levamisole induced encephalopathy were retrospectively analyzed. Gd-DTPA enhancement examinations were performed in 5 cases. CT examinations were performed in 4 cases before MRI. Results MRI features: Lesions were mainly located in bilateral periventricular and hypophloeodal white matter, scattered as multifocal lesions, and were different in sizes. Most of the lesions presented as irregular plaques (masses), with round/oval or spotty nodules in second. The lesions had low signal intensity on T 1WI and high signal intensity on T 2WI, and commonly without enhancement. Edema and mass effect were slight. CT features: Two cases showed multiple irregular plaque-sheet low density lesions scattered in bilateral periventricular white matter. One showed symmetrical low density in bilateral putamina nuclei. Another one was negative. Conclusion CT and MRI are valuable for the diagnosis and differentiated diagnosis of levamisole induced encephalopathy. MRI has higher sensitivity and specificity than CT does, and can favorably evaluate the treatment and prognosis.

objective To evaluate endoscopic surgery for high risk patients over 70 years old with severe acute cholangitis. Methods From October 1991 to October 2003, 84 high risk patients over 70 years old suffering from severe acute cholangitis were included and divided into laparotomy surgery (ST) and endoscopic surgery (ET) group. Results 80 patients were cured. The care rate was 81.2% in ST group and 91.6% in ET group. The mortality rate was lower in ET compared with ST (9.1% vs 18.8%). The rate of complication was reduced from 37.5% in ST group to 13.9% in ET group. The average duration of drainage was reduced from 49.4 days in ST group to 18.6 days in ET group. The total treatment days were shortened from 46.2 days to 22.8 days comparing ST with ET. Conclusions Endoscopic surgery should be the first choice for the senile and high risk patients with severe acute cholangitis. Endoscopic surgery was convenient, with mininal injury, safe and effective, and period of treatment was shortened, especially for elderly or critically ill patients, as well as those with MODS or previous billiary operations.

Objective To explore the protective effect of resveratrol on rat brain injury resulting from severe acute pancreatitis (SAP). Methods Ninety-six male Sprague-Dawley rats were randomly divided into four groups:sham-operation (SO) group,severe acute pancreatitis (SAP) group,resveratrol-treated (RES) group and dexamethasone-treated (DEX) group,with eight rats in each group evaluated at 3,6 and 12 h. Levels of serum myelin basic protein (MBP),tight junction protein zonula occludens 1 (Zo-1),TNF-? and IL-6 were determined by ELISA. The ultrastructural changes of the brain and pancreatic tissues were examined using a transmission electron microscope. Results MBP,Zo-1,TNF-? and IL-6 levels in RES group were lower than those in SAP group at all time points (P0.05). Conclusion The degradation of Zo-1 is involved in the pathophysiology of brain injury in SAP; MBP can be used as a marker of brain injury in SAP rats. Resveratrol can inhibit brain injury associated with SAP.

The application and development of catalytic fluorimetry in recent years were reviewed with 103 references. The new technique and application of catalytic fluorimetric methods, such as the determination of catalyst and activator, multicomponent determination, enzyme catalysis, the effect of micelle in multicomponent determination and enzyme catalysis, the combination with flow-injection or stopped-flow tachniques and laser induced fluorimetry, time resolved fluorimetry, bioreactor control, biosensor, medicine assay, bioanalysis were mainly discussed. Future study was envisioned

Objective To establish a stable brain injury model with pancreatitis and explore the mechanism of brain injury resulting from severe acute pancreatitis (SAP) in experimental rat models. Methods Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham operation (SO) group, SAP group and trypsin group, with eight rats in each. Brain tissue and pancreas tissue specimens were collected at 12 h after treatment. Death rate in each group was evaluated; the level of tight junction protein zonula occludens 1 (Zo-1) was determined by enzyme-linked immunosorbent assay. The ultrastructure of the brain tissues was examined using transmission electronic microscope; pathological changes in the brain tissues were observed with HE staining. Results The death rate was increased significantly in SAP group compared with that in trypsin group; no rats in SO group died. Zo-1 level was obviously lower in SO group than in SAP group and trypsin group (P<0.05). The ultrastructural changes were seen in the latter two groups, including obvious neuronal cell swelling, capiliary stasis, increased vascular permeability, thrombosis and cell apoptosis. Conclusion Trypsin may cause brain injury with pancratitis. The death rate of SAP model established by trypsin was low. We have provided a stable animal brain injury model for further study and treatment of brain injury.