A bronchial obstruction of the remaining lung is a rare complication of thoracic surgery. We report a case of this rare complication after a right upper lobectomy due to a giant bulla. Post-resectional angulation of the bronchus intermedius caused the bronchial obstruction. An intrabronchial stent was inserted into the bronchus intermedius, which relieved the obstruction.
Blister ; Bronchi ; Lung ; Stents ; Thoracic Surgery

Endophthalmitis following the filtering surgery is rare and the visual prognosis is reported to be very poor. In many cases the infection starts in the bleb. Methods of treatment should be chosen according to the type and stage of infection, but the prompt use of appropriate antibiotic and corticosteroid is important. This report presents a case of endophthalmitis following trabeculectomy in a 61-year old female patient, which was successfully treated.
Blister ; Endophthalmitis* ; Female ; Filtering Surgery ; Humans ; Middle Aged ; Prognosis ; Trabeculectomy*

In glaucoma filtering surgery, we conducted subconjunctival injection of Mitomycin-C(MMC) 12 hours before and after surgery, and examined histologic findings of the filtering bleb, and condition of the anterior chamber which ensued after the injection. We divided 15 full-grown rabbits into three groups, and for each group, administered subconjunctivally 0.1cc of 0.002%, 0.004%, and 0.008% MMC, respectively. The subconjunctival injection of MMC before surgery was given to the right eye and post-surgical injection to the left, and we examined the results 1, 2, 4, 7, and 14 days after the administration.In conclusion, subconjunctival injection of MMC 12 hours before glaucoma filtering surgery is shown to be more effective than the injection after the surgery.
Anterior Chamber ; Blister* ; Filtering Surgery* ; Glaucoma* ; Mitomycin* ; Rabbits

PURPOSE: To investigate the effects of varying the time of Mitomycin-C (MMC) subconjunctival injection before, during and after operation. METHOD: We divided rabbits into 3 groups according to injection time. Subconjunctival injections of 0.01% MMC 0.05 ml were given to the preoperative group at 6, 12 and 24 hours before operation, and to the postoperative group at 6, 12 and 24 hours after operation. The control group was given the injections during operation. Bleb formation and histologic analyses were studied for 4 weeks after operation. RESULTS For gross findings, the blebs of the preoperative and control groups were seen on the fourth day and completely formed at one week after operation, and were larger than those of the postoperative group. On the other hand, the blebs of the postoperative group were seen to have poor formation, displaying hypervascularity on the fourth day and disappearing one week after operation. For histologic findings, the proliferation of collagen fibers and the undifferentiation of fibroblasts observed in the preoperative and control groups were almost identical. But, the proliferation of collagen fibers and well-differentiated fibroblasts were seen to increase in the postoperative group, so aqueous flow was obstructed at week 3. CONCLUSIONS: Subconjunctival injections within 24 hours before or during glaucoma filtration surgery were better for bleb formation and preservation than those administerd after surgery.
Blister ; Collagen ; Fibroblasts ; Filtering Surgery* ; Filtration* ; Glaucoma* ; Hand ; Mitomycin* ; Rabbits*

PURPOSE: To investigate the effects of varying the time of Mitomycin-C (MMC) subconjunctival injection before, during and after operation. METHOD: We divided rabbits into 3 groups according to injection time. Subconjunctival injections of 0.01% MMC 0.05 ml were given to the preoperative group at 6, 12 and 24 hours before operation, and to the postoperative group at 6, 12 and 24 hours after operation. The control group was given the injections during operation. Bleb formation and histologic analyses were studied for 4 weeks after operation. RESULTS For gross findings, the blebs of the preoperative and control groups were seen on the fourth day and completely formed at one week after operation, and were larger than those of the postoperative group. On the other hand, the blebs of the postoperative group were seen to have poor formation, displaying hypervascularity on the fourth day and disappearing one week after operation. For histologic findings, the proliferation of collagen fibers and the undifferentiation of fibroblasts observed in the preoperative and control groups were almost identical. But, the proliferation of collagen fibers and well-differentiated fibroblasts were seen to increase in the postoperative group, so aqueous flow was obstructed at week 3. CONCLUSIONS: Subconjunctival injections within 24 hours before or during glaucoma filtration surgery were better for bleb formation and preservation than those administerd after surgery.
Blister ; Collagen ; Fibroblasts ; Filtering Surgery* ; Filtration* ; Glaucoma* ; Hand ; Mitomycin* ; Rabbits*

Endophthalmitis is a severe and unfortunate complication after glaucoma filtering surgery which may present months to years after the initial surgical intervention. Amniotic membrane is immunologically inert and has antiadhesive and wound-protectioning effects. Furthermore, it reduces pain and helps epithelization. So several reports disclosed the uses of amniotic membrane in transplantation for reconstruction of various ocular surface diseases recently. We report the usefulness of antibiotics-soaked amniotic membrane transplatation for endophthalmitis with bleb rupture 4 years after trabeculectomy.
Amnion* ; Blister ; Endophthalmitis* ; Filtering Surgery ; Glaucoma ; Rupture ; Trabeculectomy

PURPOSE: We investigated the anti-inflammatory and anti-fibrotic effects of amniotic membrane(AM) ointment in filtering surgery of rabbits. METHODS: After filtering surgery was performed on both eyes of 10 rabbits, the AM ointment was applied over and under the scleral flap on one eye whereas base ointment excluding AM element was applied to the other as a control. The shapes of blebs were observed under slit-lamp biomicroscopy at postoperative 3 days, 1 week, 2 weeks and 4 weeks, and the tissues were excised for histologic studies. RESULTS: Serial changes of intraocular pressures had no significant difference. Slit-lamp biomicroscopy demonstrated that conjunctival blebs of AM ointment group were more elevated and cystic at 1 and 2 weeks. The heights of conjunctival blebs were significantly higher at 1, 2 and 4 weeks, and the width of scleral tracks was significantly wider at 1 and 2 weeks in AM ointment group. The number of inflammatory cells in the scleral track was significantly less at 3 days and 1 week, the number of fibroblasts in scleral track was significantly less at 2 and 3 weeks in AM ointment group. Masson s trichrome stain was less positive in AM ointment and the stain area of alpha-smooth muscle actin-positive fibroblasts was insignificant with image analysis system. Collagen type 3 appeared in scleral track from postoperative 1 week in control group, however, in AM ointment group, from 4 weeks. CONCLUSIONS: AM ointment is beneficial to suppress fibroblast differentiation, proliferation and inflam-matory reaction in filtering surgery and might be safe and effective adjunctive for enhancement of success in filtering surgery.
Amnion* ; Blister ; Collagen ; Fibroblasts ; Filtering Surgery* ; Humans* ; Intraocular Pressure ; Rabbits*

An overhanging, large bleb after filtering surgery leads to various complications ranging from foreign-body sensation to endophthalmitis. Herein we report two case of large painful blebs in nasal area. Argon laser was initially used for its shrinkage. However, this procedure was not successful, requiring surgical excision of bleb. The tissue was then examined to evaluate the cause of failure with the argon laser treatment. On examination, the bleb showed a pseudocyst, and hyaline degeneration in the inner membrane of the bleb. Shrinkage of the large bleb resulted in resolution of the pain.
Argon ; Blister* ; Endophthalmitis ; Filtering Surgery* ; Glaucoma* ; Hyalin ; Membranes ; Sensation

Various studies have been performed to identify change in the constituents of aqueous humor which was suggested either as a factor for fibroblast proliferation causing glaucoma filtering bleb failure or as a factor for the pathogenesis of primary open angle glaucoma. This study was designed to investigate change of aqueous humor composition after long-term topical antiglaucoma medication. After 16-week instillation of pilocarpine 4% and Betagan(TM) in ten rabbits, aqueous humor was obtained from eight control and eight experimental eyes. Protein bands were identified by SDS-PAGE and gold staining techniques. The density and distribution of these protein bands was significantly different between the two groups. The result of this study may give help for future study of pathogenesis of primary open angle glaucoma and causes of high failure rate after glaucoma filtration surgery in patients on chronic topical antiglaucoma medication.
Aqueous Humor* ; Blister ; Electrophoresis, Polyacrylamide Gel ; Fibroblasts ; Filtering Surgery ; Glaucoma ; Glaucoma, Open-Angle ; Humans ; Pilocarpine ; Rabbits*

The conjunctival wound leakage that occurs often afterglaucoma filtering surgery may predispose to the development of hypotony, infection, and bleb failure, so primary resuturing is tried to prevent them usually. Recently, because of the friable conjunctiva due to the use of mitomycin C(MMC) during the glaucoma filtering surgery, re-leakage is frequent after resuturing. We thought of the method that compress the leaking site without direct injury to leaking conjunctival wound and tried to the 4 patients, 6 eyes with the conjunctival wound leakage who had received the MMC trabeculectomy with fornix based conjunctival flap. We performed the suture posterior to the leaking sithe across the conjunctival flap with the nonabsorbing suture material after local anesthesia for the block of leakage due to the compression. Postoperatively, the sutures were removed at the time of no leakage and complete healing at conjunctival wound. And we had a good results in all 6 eyes in recent 2 years. The method of compression using this suture is one adequate method of management in conjunctival wound leakage after glaucoma filtering surgery.
Anesthesia, Local ; Blister ; Conjunctiva ; Filtering Surgery ; Glaucoma ; Humans ; Mitomycin ; Suture Techniques* ; Sutures* ; Trabeculectomy ; Wounds and Injuries*