1.Biphenotypic blast crisis of chronic myelopenous leukemia.
Dong Il WON ; Baek Soo KIM ; Chung Hyun NAM ; Yoon Jeong DOH ; Oh Hun KWON ; Yoo Hong MIN
Korean Journal of Clinical Pathology 1992;12(3):337-340
No abstract available.
Blast Crisis*
;
Leukemia*
2.Biphenotypic blast crisis of chronic myelopenous leukemia.
Dong Il WON ; Baek Soo KIM ; Chung Hyun NAM ; Yoon Jeong DOH ; Oh Hun KWON ; Yoo Hong MIN
Korean Journal of Clinical Pathology 1992;12(3):337-340
No abstract available.
Blast Crisis*
;
Leukemia*
3.Extramedullary blast crisis of secondary CML accompanying marrow fibrosis.
Korean Journal of Hematology 2012;47(4):243-243
No abstract available.
Blast Crisis
;
Bone Marrow
;
Fibrosis
4.Pediatric chronic myeloid leukemia with B-cell lymphoid blast crisis at presentation.
Prasad IYER ; Peter CAREY ; Nick BOWN ; Sujith SAMARASINGHE
Blood Research 2013;48(2):151-152
No abstract available.
B-Lymphocytes
;
Blast Crisis
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
5.Acute megakaryoblastic blast crisis as a presentation manifestation of chronic myelogenous leukemia.
Jenna B BHATTACHARYA ; Richa GUPTA ; Amit SAMADHIYA
Blood Research 2017;52(2):137-139
No abstract available.
Blast Crisis*
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
;
Megakaryocyte Progenitor Cells*
6.Genomic Instability in Acute Transformation of Chronic Myelogenous Leukemia.
Journal of Experimental Hematology 2015;23(4):1199-1202
Chronic myeloid leukemia (CML) is a myeloproliferative disorder, characterized by excessive proliferation of myeloid cells. CML patients in early phase [also known as chronic phase (CP)] usually respond to treatment with tyrosine kinase inhibitors (TKI), some patients respond initially to TKI, but later become resistant, then resulting in the transformation from CP to more advanced phase, which were subclassified as either accelerated phase or blastic phase. At present, the molecular mechanisms of CML have been not yet clear, and acute transformation has been not fully understood, studies have shown that genomic instability promotes the acute conversion of CML. This review discusses the molecular mechanisms leading to the transformation of CML, and some therapeutic approaches.
Blast Crisis
;
Drug Resistance, Neoplasm
;
Genomic Instability
;
Humans
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
7.One of the Mechanisms in Blastic Transformation of Chronic Myeloid Leukemia: Epigenetics Abnormality--Review.
Journal of Experimental Hematology 2016;24(1):250-253
Chronic myeloid leukemia is a myeloproliferative disorder characterized by excessive cloning of bone marrow multipotent stem cells. According to the disease course, the CML may be divided into chronic phase (CP), accelerated phase (AP) and blastic phase (BP). At present, the molecular mechanisms of acute transformation of CML has not been fully understood. The recent studies have shown that the epigenetics is one of mechanisms in blastic transformation of CML, including three molecular mechanisms such as DNA modification, histone modifications and RNA-related dysregulation. The molecular mechanisms for epigenetics leading to the transformation of CML are discussed in this review.
Blast Crisis
;
genetics
;
Disease Progression
;
Epigenesis, Genetic
;
Humans
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
genetics
9.A Case of Myeloid Blast Crisis of Atypical Chronic Myelogenous Leukemia.
Hee Soon CHO ; Chae Hoon LEE ; Kyung Dong KIM ; Kyung Hee LEE ; Sung Hwa BAE ; Duck CHO ; Dong Wook RYANG
Korean Journal of Hematology 2003;38(3):200-204
Atypical chronic myelogenous leukemia (aCML) has dysplastic as well as proliferative features in most instance and rarely evolves to blast crisis, so it is considered as a distinct clinical entity to classical BCR-ABL (+) CML. We experienced a patient who are diagnosed aCML and transformed to myeloid blast crisis after 17 months. Monosomy 7 and deletion of 12p were found on conventional cytogenetics.
Blast Crisis*
;
Cytogenetics
;
Humans
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
;
Monosomy
10.Rapid promyelocytic blast crisis of chronic myeloid leukemia with PML-RARα fusion gene: a case report and literature review.
Ming Suo LIU ; Xiao Yan HAN ; Zhi Gang QU ; Qiu Lian LUO ; Kang Li WU ; Jin CHEN ; Ya Jun WU ; Wan Ling XU ; Xi Xi YANG ; Yuan Yuan ZHU
Chinese Journal of Hematology 2023;44(6):512-515