1.Recent advances in diagnosis of flat lesions of urinary bladder.
Liang CHENG ; Jia-wen XU ; Xiao-Dong TENG
Chinese Journal of Pathology 2010;39(9):577-581
Antigens, CD20
;
metabolism
;
Carcinoma in Situ
;
classification
;
diagnosis
;
metabolism
;
pathology
;
Diagnosis, Differential
;
Humans
;
Hyaluronan Receptors
;
metabolism
;
Hyperplasia
;
Precancerous Conditions
;
diagnosis
;
metabolism
;
pathology
;
Tumor Suppressor Protein p53
;
metabolism
;
Urinary Bladder
;
metabolism
;
pathology
;
Urinary Bladder Neoplasms
;
classification
;
diagnosis
;
metabolism
;
pathology
;
Urothelium
;
metabolism
;
pathology
2.The loss of expression of transforming growth factor-beta receptors correlates with the histopathologic tumor grade in bladder transitional cell carcinoma patients.
Dong Hyeon LEE ; Seung Choul YANG ; Sung Joon HONG ; Byung Ha CHUNG ; Hyun Jik CHUNG ; Hideo TOKUNAGA ; Issac Y KIM ; Yun S SONG ; Seth P LERNER ; Ronald A MORTON
Yonsei Medical Journal 1999;40(2):118-123
Transforming growth factor-beta (TGF-beta), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss of sensitivity to TGF-beta through a loss of expression of TGF-beta receptors T beta R-I and T beta R-II--is associated with tumor initiation and progression. Therefore, to investigate the relationship between TGF-beta receptors expression and carcinogenesis of bladder TCC, this study examined the expression of T beta R-I and T beta R-II in 46 bladder TCC patients using immunohistochemistry. Since histopathological grade is a widely accepted marker of prognosis, the results were compared in relation to the three grades of bladder TCC. The results demonstrated that the loss of TGF-beta receptors expression is associated with increasing histopathological grades of bladder TCC. Specifically, both T beta R-I and T beta R-II were readily detected in all 10 normal bladder mucosa specimens. Likewise, all 6 specimens of grade I TCC samples expressed high levels of both TGF-beta receptors. However, among grade II TCC samples, T beta R-I and T beta R-II were detected in 78% and 89%, respectively: among grade III TCC samples, T beta R-I and T beta R-II were detected in 45% and 41%, respectively. These results suggested that loss of sensitivity to TGF-beta may play a role in the progression of TCC from low to high grade disease.
Adult
;
Aged
;
Bladder Neoplasms/pathology*
;
Bladder Neoplasms/metabolism*
;
Carcinoma, Transitional Cell/pathology*
;
Carcinoma, Transitional Cell/metabolism*
;
Human
;
Middle Age
;
Receptors, Transforming Growth Factor beta/metabolism*
;
Reference Values
3.Pathologic diagnosis of benign glandular lesions of urinary bladder.
Chinese Journal of Pathology 2011;40(3):147-150
Adenoma
;
metabolism
;
pathology
;
Biomarkers, Tumor
;
metabolism
;
Cystadenocarcinoma
;
pathology
;
Cystitis
;
metabolism
;
pathology
;
Endometriosis
;
immunology
;
pathology
;
Fallopian Tube Neoplasms
;
pathology
;
Female
;
Humans
;
Intestines
;
pathology
;
Keratin-7
;
metabolism
;
Male
;
Metaplasia
;
pathology
;
Racemases and Epimerases
;
metabolism
;
Urinary Bladder Neoplasms
;
metabolism
;
pathology
;
Uterine Diseases
;
immunology
;
pathology
4.Perivascular epithelial cell tumor of urinary bladder.
Fen ZHANG ; Yan-hui LIU ; Xin-lan LUO ; Heng-guo ZHUANG
Chinese Journal of Pathology 2009;38(2):131-132
Actins
;
metabolism
;
Adult
;
Female
;
Humans
;
Melanoma-Specific Antigens
;
metabolism
;
Microphthalmia-Associated Transcription Factor
;
metabolism
;
Perivascular Epithelioid Cell Neoplasms
;
metabolism
;
pathology
;
surgery
;
Urinary Bladder
;
metabolism
;
pathology
;
surgery
;
Urinary Bladder Neoplasms
;
metabolism
;
pathology
;
surgery
5.Recent advances in pathology and molecular genetics of small cell carcinoma of the urinary bladder.
Liang CHENG ; Wen-bin HUANG ; Jie CHEN
Chinese Journal of Pathology 2007;36(10):700-703
Biomarkers, Tumor
;
metabolism
;
Carcinoma, Small Cell
;
genetics
;
metabolism
;
pathology
;
Carcinoma, Squamous Cell
;
pathology
;
Chromosome Aberrations
;
Diagnosis, Differential
;
Humans
;
Keratins
;
metabolism
;
Lymphoma
;
pathology
;
Mucin-1
;
metabolism
;
Urinary Bladder
;
pathology
;
Urinary Bladder Neoplasms
;
genetics
;
metabolism
;
pathology
6.Malignant granular cell tumor of the urinary bladder.
Yan-zhen ZHUANG ; Xian-yi JIANG ; Pei-qiong CHEN
Chinese Journal of Pathology 2006;35(3):188-188
Cystectomy
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Fatal Outcome
;
Female
;
Glial Fibrillary Acidic Protein
;
metabolism
;
Granular Cell Tumor
;
pathology
;
secondary
;
surgery
;
Humans
;
Immunohistochemistry
;
Middle Aged
;
S100 Proteins
;
metabolism
;
Urinary Bladder
;
chemistry
;
pathology
;
surgery
;
Urinary Bladder Neoplasms
;
metabolism
;
pathology
;
surgery
;
Vaginal Neoplasms
;
metabolism
;
secondary
;
surgery
7.Expression of Engrailed-2 and β-catenin in bladder urothelial carcinoma and their significance.
Yunfei LI ; Haitao LIU ; Xinghua DU ; Caiyong LAI ; Zexuan SU ; Shuangquan GAO
Journal of Southern Medical University 2013;33(9):1372-1376
OBJECTIVETo investigate the expressions of Engrailed-2 (EN2) and β-catenin in bladder urothelial carcinoma and explore their significance.
METHODSSixty bladder urothelial carcinoma samples of different grades and stages and 10 normal bladder mucosal tissues were examined for expressions of EN2 and β-catenin proteins and mRNA using immunochemistry, Western blotting and RT-PCR. RESULTS Compared to normal bladder mucosa, bladder urothelial carcinoma tissues showed significantly increased expressions of EN2 and β-catenin proteins (P<0.05), and the high-grade carcinoma tissues exhibited significantly stronger expressions than the low-grade ones (P<0.05); the expressions of the proteins increased also significantly with advanced pathological stages of bladder urothelial carcinoma (P<0.05). The expressions of EN2 and β-catenin mRNAs showed a consistent pattern of changes with their protein expressions.
CONCLUSIONThe expressions of EN2 and β-catenin are significantly increased in bladder urothelial carcinoma. EN2 may contribute to the development and progression of bladder urothelial carcinoma by activating Wnt/β-catenin signal pathway.
Adult ; Aged ; Aged, 80 and over ; Carcinoma ; metabolism ; pathology ; Female ; Homeodomain Proteins ; metabolism ; Humans ; Male ; Middle Aged ; Nerve Tissue Proteins ; metabolism ; Urinary Bladder Neoplasms ; metabolism ; pathology ; beta Catenin ; metabolism
8.Expression and prognostic significance of survivin in the progression of bladder transitional cell cancer.
Yanbo, WANG ; Zhaohui, ZHU ; Fuqing, ZENG ; Liang, WANG ; Yu, WU ; Wei, XIA ; Shi'an XING
Journal of Huazhong University of Science and Technology (Medical Sciences) 2007;27(4):444-7
The expression of survivin, a member of inhibitor of apoptosis (IAP) family, was examined in bladder transitional cell cancer (BTCC) tissue and adjacent normal tissues to examine its clinical implication in the development of BTCC. Thirty specimens of bladder cancer were detected for the expression of survivin by using immunohistochemistry and real-time quantitative reverse transcription polymerase chain reaction (RT-QPCR) in BTCC tissue and adjacent normal tissues. Our results showed that the positive rate of survivin immunostaining specimen were 0 and 60% (18/30) in the adjacent normal tissues, bladder cancer, respectively. The-DeltaDeltaCT value of survivin in bladder cancer tissue was 10.2829 (9.0034-11.5624) times that in the adjacent normal tissues. The expressions of survivin were correlated with the pathological grades of tumor and clinical stages. It is concluded that there was only weak expression of survivin mRNA in the adjacent normal tissues, but the expression of survivin mRNA in bladder cancer tissue was much higher than that in the adjacent normal tissues and the expression of survivin was correlated with pathological grades and clinical stages of tumor.
*Carcinoma, Transitional Cell/metabolism
;
*Carcinoma, Transitional Cell/pathology
;
Microtubule-Associated Proteins/genetics
;
Microtubule-Associated Proteins/*metabolism
;
Prognosis
;
RNA, Messenger/genetics
;
RNA, Messenger/metabolism
;
Tumor Markers, Biological/genetics
;
Tumor Markers, Biological/*metabolism
;
Urinary Bladder Neoplasms/*metabolism
;
Urinary Bladder Neoplasms/*pathology
9.Sarcomatoid carcinoma of the urinary tract: clinical analysis of 16 cases.
Cheng ZHOU ; Li-Ping XIE ; Xiang-Yi ZHENG
Chinese Journal of Oncology 2011;33(8):634-635
Carcinoma, Renal Cell
;
metabolism
;
pathology
;
surgery
;
Carcinoma, Transitional Cell
;
metabolism
;
pathology
;
surgery
;
Carcinosarcoma
;
metabolism
;
pathology
;
surgery
;
Female
;
Follow-Up Studies
;
Humans
;
Keratins
;
metabolism
;
Kidney Neoplasms
;
pathology
;
surgery
;
Lymphatic Metastasis
;
Male
;
Prostatic Neoplasms
;
metabolism
;
pathology
;
surgery
;
Retrospective Studies
;
Survival Rate
;
Ureteral Neoplasms
;
metabolism
;
pathology
;
surgery
;
Urinary Bladder Neoplasms
;
metabolism
;
pathology
;
surgery
;
Urologic Neoplasms
;
metabolism
;
pathology
;
surgery
;
Vimentin
;
metabolism
10.Hepatic and renal injury induced by Radix Aristolochiae or Guanxin Suhe Wan for a long-term in rats.
Hong-Xiang QIAO ; Yong-Ye LIU ; Li-Mao WU ; Lian-Da LI
China Journal of Chinese Materia Medica 2008;33(9):1044-1048
OBJECTIVETo evaluate the toxicity of Radix Aristolochiae supplied experimental evidence of rational use of drug in clinic.
METHODAfter treatment with small dose Radix Aristolochiae, Guanxin Suhe Wan (with Radix Aristolochiae) and Guanxin Suhe Wan (without Radix Aristolochiae) in different group for a long- term, respectively, the biochemical indicator of PT, ALT, AST, ALB, ALP, Crea and BUN were detected, and the kidney, liver, stomach and urinary bladder were examined by pathologic assaying.
RESULTIn Radix Aristolochiae group and Guanxin Suhe Wan (with Radix Aristolochiae) group, all of biochemical indicator were changed significantly, and hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered.
CONCLUSIONRadix Aristolochiae and Guanxin Suhe Wan (with Radix Aristolochiae) can damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity.
Animals ; Aristolochia ; chemistry ; toxicity ; Drugs, Chinese Herbal ; toxicity ; Kidney ; drug effects ; metabolism ; pathology ; Liver ; drug effects ; metabolism ; pathology ; Male ; Rats ; Rats, Sprague-Dawley ; Stomach Neoplasms ; chemically induced ; Urinary Bladder ; drug effects ; metabolism ; pathology ; Urinary Bladder Neoplasms ; chemically induced