In recent years, traditional Chinese medicine combined with 5-fluorouracil (5-FU) in the treatment of tumors, especially digestive system tumors, has achieved promising results.The current research shows that the combination of traditional Chinese medicine and 5-FU can enhance tumor inhibition rate, prolong survival period of patients, improve immunity and quality of life of patients, and significantly reduce side effects such as bone marrow suppression, liver and kidney toxicity and gastrointestinal reactions and so on.Therefore, traditional Chinese medicine combined with 5-FU can have synergistic and attenuated effects.

Objective To compare the effects of different spleen-strengthening recipes on water-electrolyte metabolism and water transport in rat model of spleen-deficiency syndrome. Methods The male Wistar rats were randomly assigned into the normal group and spleen-deficiency model group. The rat model of spleen-deficiency was established by overstrain plus disordered diet method. On the 15th modeling day, the model rats were randomly assigned into model group , Buzhong Yiqi Tang(BYT) group, Si Junzi Tang(SJT) group, Shenling Baizhu San(SBS) group, and the rats except for the model group were treated with gastric gavage of the corresponding medicine in the dosage of 4.05 g·kg-1·d-1. Rats of normal group and model group were given equal volume of normal saline. The medication lasted for 14 days. On the 29th experimental day, we detected serum Na+ and K+, plasma antidiuretic hormone(ADH) and aldosterone(ALD), aquaporin 3(AQP3) in the small intestine and colon, and renal AQP2. Results Compared with the normal group, plasma ADH and ALD levels, serum Na+ level, renal AQP2 content in the model rats were increased significantly, serum K+ and AQP3 content of small intestine and colon mucosa was decreased significantly(P<0.01). Compared with the model group, plasma ADH and ALD levels, serum Na+ level, renal AQP2 content in the three medication groups were decreased significantly, serum K+level and AQP3 in the small intestine and descending colon mucosa was increased significantly(P<0.05 or P<0.01). Of the three medication groups, SBS group had lower ADH, ALD, Na+levels, and higher serum K+level and AQP3 in the small intestine and descending colon mucosa than BYT group and SJT group(P<0.01); SBS group and BYT group had lower renal AQP2 than SJT group(P<0.05 or P<0.01). Conclusion Rat model with spleen-deficiency syndrome has disordered water-electrolyte metabolism and abnormal water transport. The spleen-strengthening recipes, which have the actions of strengthening spleen, strengthening spleen to drain dampness, strengthening spleen to elevate yang, can improve the disorder of water metabolism to some degrees, and SBS has the best effect.

For the employment orientation of graduates in clinical medical major from three-year medical eduction,a curriculum system,which will be used to foster practical medical talented person for urban and rural communities,has been proposed in this paper.We will take measures,which not only further defines training target and requirement for the practical medical person from the short school system and guides students to alterate their ideological concept but also reconstructures new curriculum system and reforms teaching methods,to ensure the implementation of the training objectives

Objective To investigate the changes of estrous cycle and the preventive and therapeutic effects of Chaihu Shugan San(Radix bupleuri liver-soothing Powder,CHSGS)in female rats with liver-stagnation pattern.Methods Female rats were randomly divided into normal group, liver-stagnation group,high-dose CHSGS group(H group), and low-dose CHSGS group(L group)(n =10 in each group).Liver stagnation pattern was established by using chronic restraint stress for 4 weeks.After mod-eling for 14 days,rats in the H and L groups were given the investigated medicine at the dose of 1.26 g/kg and 0.31 g/kg(equivalent to 2 and 0.5 times of human dosage)respectively, once a day for 2 weeks.Rats in the model group and the normal group were given the same amount of distilled water.At week 2 and week 4,sucrose preference test(SPT)was conducted; At week 4, open field test(OFT) was performed.Rat estrous cycles were observed by using vaginal smears.General observation was used throughout the experiment.Results At week 2, compared with the normal group, the model group showed a state of hyperactivity,irritability,reduced and slower mobility,and reduced food-intake.SPT were higher at week 2 but decreased at week 4(P<0.01).Estrous cycle disorders were also reduced (P<0.01).Duration in central zone(Index S),cubicle-crossing counts(Index C)and vertical move-ments(Index N)decreased in OFT test(P<0.01).Compared with the model group, the activities of the rats in the H group were more similar to the control group,with the duration in the central zone and vertical movements higher than those in the model group(P<0.01)and SPT decreased(P<0.01). Disordered estrous cycles decreased in H group(P<0.01).The above-mentioned changes were not ob-served in the L group(P>0.05).Conclusion Behavior changes with estrous cycle disorders were ob-served in female rat with liver-stagnation model established by chronic restraints stress.Chaihu Shugan San appeared to be effective in relieving the symptoms and estrous cycle disorders.High-dose CHSGS was superior to low-dose CHSGS.

Objective To observe and compare the effects of three reinforcing spleen formulas (Buzhong Yiqi Decoction,Sijunzi Decoction,Shenling Baizhu Powder)on the changes of skeletal muscle power in rats model with spleen deficiency pattern.Methods Male Wistar rats were randomly divided into normal group,model group,Buzhong Yiqi Decoction (BZYQD)group,Sijunzi Decoction (SJZD)group and Shenling Baizhu Powder (SLBZP)group.Except the normal group,the rats of the four groups were modeled after over fatigue and improper diet for consecutive four weeks.On Day 15 after modeling,three medication groups were intragastrically administered (i.g.)corresponding Chinese medicines at dose of 4.05 g/(kg·d),while model group and normal group were i.g.administered distilled water at the same dose,for consecutive 14 days.Then grip strength was measured,biochemical indexes of blood and skeletal muscle were detected,and the pathological changes of skeletal muscle were observed.Results Compared with normal group,the indexes of rats of normal group,involving grip strength,succinate de-hydrogenase (SDH)in skeletal muscle,creatine kinase isoenzyme (CK-MM),Ca2 +-ATPase,M-ACh-RM2 and Musclin decreased significantly,while serum AchE increased significantly (P <0.01 or P <0. 05).Inflammatory cell infiltration was observed in skeletal muscle,and muscle fiber was scattered in dis-order with uneven thickness,loose arrangement and vacuole degeneration in model group.Compared with model group,the biochemical indexes and pathological changes of the three medication groups were amel-iorated,among which the grip strength,SDH,CK-MM,M-AChRM2 of skeletal muscle in BZYQD group were higher significantly than those of SJZD group and SLBZP group (P <0.01 or P <0.05).Conclu-sion Skeletal muscle injuries were found in rats with spleen deficiency pattern.In TCM,Sijunzi Decoc-tion has been used for reinforcing spleen,Shenling Baizhu Powder been used for reinforcing spleen and e-liminating dampness,and Buzhong Yiqi Decoction been for reinforcing spleen and rising yang.The three formulas could improve the skeletal muscle of rat model with spleen deficiency pattern,in which Buzhong Yiqi Decoction showed the best efficacy.

Objective To explore the effect of Chinese medicine liquid to gargle on the oral mucosa reaction in nasopharyngeal carcinoma patients with radiotherapy .Methods One hundred nasopharyngeal carcinoma patients with radiotherapy were divided into the control group and the observation group according to the random number table , each with 50 cases.The control group received anti-inflammatory mouthwash to gargle, which included gentamicin 4 ml, dexamethasone 5 mg, lidocaine 20 ml, NS 250 ml, 5% sodium bicarbonate 250 ml.The observation group received the Chinese medicine liquid to gargle , which included AMUR CORK TREE BARK 25 g, SCUTELLARIA 25 g, DANDELION 25 g, MINT 5 g and were gargled before and after three meals a day, before radiotherapy, before bedtime.The microbiology in oropharyngeal was monitored during the treatment and after radiotherapy according to WHO oral mucosa radiation damage grading criteria . Results The oral mucosa reactions in the observation group were all lighter than those in the control group at the third weekend, the seventh weekend , and one week after radiotherapy , and the differences were statistically significant (Z=37.645,22.880,10.874, respectively;P <0.05).The positive rate of throat swab bacterial culture was 16.0%(8/50) in the observation group , and was 34.0%(17/50) in the control group at the seventh weekend, and the difference was statistically significant (χ2 =4.320,P<0.05).Conclusions Chinese medicine liquid to gargle can effectively prevent and relieve the oral mucosa reaction induced by the radiotherapy for the treatment of nasopharyngeal carcinoma , and reduce oral infection .

Lung adenocarcinoma is a malignant tumor that is prone to distant metastasis. Common metastatic sites are brain, adrenal gland, liver, bone, and so on. Skin soft tissue metastasis is unusual, and breast metastasis is even rarer. This case is a middle-aged female patient who had experienced multi-line treatments for upper limbs, abdominal skin, and bilateral breast tissue metastases.The patient's multiple metastases were susceptible to radiation therapy.Reviewing the entire treatment process of this patient can find that the rational use of individualized comprehensive treatment methods and appropriate timing of genetic testing are very important for patients with lung adenocarcinoma to prolong their survival time and improve their quality of life.
Adenocarcinoma of Lung ; Breast Neoplasms ; Female ; Humans ; Lung Neoplasms ; Middle Aged ; Quality of Life