Objective To introduce a new method and new material in repairing nasal septum perforation.Methods Under toponarcosis, at anterior border of the cartilage of nasal septum, the mucoperiosteum was cut and ablated the operative mucoperoosteum side concerned to the perforation edge to form an annular implanting bed which was 0.5 cm wide size of the mucoperiosteum. The silica gel patch according to the hole size and shape of the cartilage defect was made and and a lot of little holes were drilled on the edge of the silica gel patch for the purpose of the connective tissue approaching the holes and fixing the silca gel patch. After that, the silca gel patch was imbed in the place of cartilage defect and the mucoperisteum on the both sides were restored. Finally, the both nasal cavity were filled up with oil-gauze. Results Of the 12 cases of repairing nasal septum perforation with silica gel patch, 11 were successful. The patients was followed up for 1～4 years no relapse.Conclusions This repairing method is easy plentiful materials source, and have not any reject reaction. And success rate is fairly high.