Objective To explore the application value of hospital execution culture in healthcare-associated infec-tion(HAI)management.Methods All departments in a hospital from January 1 ,2013 to December 31 ,2014 were studied.From January 1 ,2014,ideas and fostering methods for hospital execution culture were applied in HAI management,the working enthusiasm,working ability,and working achievements of health care workers (HCWs) on HAI control before and after the application of execution culture were compared.Results 53 departments in the hospital were surveyed annually in 2013 and 2014.Working enthusiasm:the number of departments participating in hospital-wide training increased from 24 (45.28%)to 49 (92.45%),the number of departments that carried out subsequent training increased from 21(39.62%)to 48(90.57%),departments that initiatively carried out self-inspec-tion increased from 10(18.87%)to 43(81 .13%),differences were all significant (all P <0.001).Working ability:percentage of HCWs knew knowledge about hand hygiene as well as prevention and control measures for multidrug resistance bacteria increased from 49.05% (103/210)and 37.14% (78/210)to 96.30% (208/216)and 97.22%(210/216)respectively;while in 2013,only 2 departments (3.77%)performed regular rectification on daily work, which increased to 19 departments (35.85%)after training,differences were all significant (all P <0.001).Working achievements:the qualified rate of correct hand hygiene among HCWs increased from 8.57%(18/210)to 87.04%(188/216);implementation rate of multidrug resistance bacteria isolation increased from 50.00% to 80.08%,path-ogenic detection in patients receiving therapeutic antimicrobial agents increased from 28.85% to 51 .30%,differ-ences were all significant(all P <0.001).Conclusion Fostering of hospital execution culture has improved the en-thusiasm and work ability of HCWs to participate in HAI management,promoted the implementation of HAI man-agement,and is a powerful tool for the management of HAI.

In recent years,the number of diagnosed therapy-related hematological neoplasms has increased.Compared to primary hemato-logical neoplasms,therapy-related hematological neoplasms have a poorer prognosis and are a serious complication following the treat-ment of solid tumors.Clonal hematopoiesis of indeterminate potential(CHIP)is considered a relevant factor in the pathogenesis of therapy-related myeloid neoplasms(t-MNs),leading to an increased risk of t-MN by promoting driver gene mutations.The pathogenesis of therapy-related hematological neoplasms primarily involves alkylating agents,topoisomerase inhibitors,platinum agents,poly ADP-ribose poly-merase(PARP)inhibitors,and radiotherapy.Currently,allogeneic stem cell transplantation remains the most effective therapeutic option.This review analyzes advances in the epidemiology,pathogenesis,related drugs,prognosis,and treatment of therapy-related hematological neoplasms.