Objective To explore the clinical significance in combined detection of C-reactive protein and the cervical secretion smear in chorioamnionitis with preterm premature rupture of membranes (PPROM).Methods Eighty patients with PPROM (PPROM group) were selected and divided into chorioamnionitis group (n =55) and without chorioamnionitis(n =25) according to the diagnosis.The levels of C-reactive protein and cervical smear were analysis,including sensitivity,specificity,positive predictive value and negative predictive value.Sixty cases of preterm no premature rupture of membranes pregnant women with the same gestational age were chosed as the control group.Results The positive rate of CRP and cervical secretions smear in PPROM group were higher than those of control group,and the differences were statistically significant (x2 =50.24,54.81 ;P ＜ 0.05).The sensitivity,specificity,positive predictive value and negative predictive value by the CRP diagnosis of chorioamnionitis in patients with PPROM were 58.18％,63.64％,36.00％,32.00％ respectively.Those indices of cervical secretions smear diagnosis were 66.67％,67.31％,29.03％,28.57％ respectively.The sensitivity,specificity,positive predictive value regarding of CRP and cervical secretions smear joint inspection diagnosis of chorioamnionitis were 69.09％,88.00％,92.68％,56.41％ respectively.Conclusion The inspection of CRP combined with cervical secretion smear can improve specificity and positive predictive value of chorioamnionitis diagnosis with PPROM pregnant women.

Objective To obtain a more accurate assessment of prognostic significance of NLR in ovarian cancer. Methods A systematic literature search was conducted using the electronic databases PubMed ,Web of Science,and Embase up to May 2016. Hazard ratio(HR)and odds ratio(OR)with 95% confidence interval (95%CI)were calculated. Statistical analysis was performed using Stata 12.0. Results 12 studies,consisting of 3 ,854 patients ,were selected in this meta-analysis. High NLR level was significantly associated with poorer overall survival(OS)(HR:1.69)and shorter progression free survival(PFS)(HR 1.63). Additionally,increased NLR was significantly correlated with advanced FIGO stage(OR 2.32),higher level of CA-125(OR 3.33),more extensive ascites(OR 3.54)as well as less chemotheraputic response(OR 0.53). Conclusions Elevated pretreat-ment NLR can serve as a predicative factor of poor prognosis for ovarian cancer.

Thyroid is an important endocrine organ of the human body for secreting necessary thyroid hormone, which is important to promote the development of human skeleton and nervous system.Thyroid hormone is used to evaluate thyroid function, changing by different race, gender, age, living habits, living area, iodine intake levels and so on.Various laboratory testing instrument and supporting reagents also can affect thyroid hormone reference range.At present, laboratory only sets special thyroid hormone reference interval for pregnant women, and does not set reference interval according to specific age and gender.