Objective To observe the effect of carboprost tromethamine(hemabate) combined with modified patch suture in placenta previa postpartum hemorrhage.Methods 62 patients with placenta previa were divided into the control group (3 0 cases) and treatment group (3 2 cases).The control group was treated with hemabate,and the treatment group was treated with hemabate combined with modified patch suture.The two groups of intraoperative,postpartum 2 hours,24 hours postpartum were compared in bleeding volume and hemoglobin changes.Results The intraoperative bleeding volume [(321.9 ± 67.8) ml vs (435.9 ± 83.3) ml] and 2h,24h postpartum bleeding volume [(417.7±68.0)ml vs (539.6 ±70.4)ml and (485.3 ±68.5)ml vs (621.0±81.3)ml]of the treatment group were significant less than that of the control group(t =5.926,6.938,7.133,all P ＜ 0.05).Significant difference in changes of hemoglobin level was also observed between the two groups,though postpartum level was not significantly reduced in the treatment group compared with the control group [(5.0 ± 6.5) g/L vs (-4.0 ± 6.8) g/L] (t =-3.662,P ＜ 0.05).Conclusion Hemabate combined with modified patch suture can be more effective in the prevention of postpartum haemorrhage in placenta previa.

Objective To explore the clinical significance in combined detection of C-reactive protein and the cervical secretion smear in chorioamnionitis with preterm premature rupture of membranes (PPROM).Methods Eighty patients with PPROM (PPROM group) were selected and divided into chorioamnionitis group (n =55) and without chorioamnionitis(n =25) according to the diagnosis.The levels of C-reactive protein and cervical smear were analysis,including sensitivity,specificity,positive predictive value and negative predictive value.Sixty cases of preterm no premature rupture of membranes pregnant women with the same gestational age were chosed as the control group.Results The positive rate of CRP and cervical secretions smear in PPROM group were higher than those of control group,and the differences were statistically significant (x2 =50.24,54.81 ;P ＜ 0.05).The sensitivity,specificity,positive predictive value and negative predictive value by the CRP diagnosis of chorioamnionitis in patients with PPROM were 58.18％,63.64％,36.00％,32.00％ respectively.Those indices of cervical secretions smear diagnosis were 66.67％,67.31％,29.03％,28.57％ respectively.The sensitivity,specificity,positive predictive value regarding of CRP and cervical secretions smear joint inspection diagnosis of chorioamnionitis were 69.09％,88.00％,92.68％,56.41％ respectively.Conclusion The inspection of CRP combined with cervical secretion smear can improve specificity and positive predictive value of chorioamnionitis diagnosis with PPROM pregnant women.

Objective:To investigate outcomes and safety of doxycycline-moxifloxacin sequential regimen in the treatment of Mycoplasma genitalium urethritis/cervicitis. Methods:From June 2019 to December 2020, patients with Mycoplasma genitalium urethritis/cervicitis confirmed by nucleic acid amplification testing were successively recruited at Department of Sexually Transmitted Diseases, Hospital of Dermatology, Chinese Academy of Medical Sciences, and received sequential therapy with oral doxycycline for 7 days followed by oral moxifloxacin for 7 days. Clinical and/or etiological assessment was conducted 2 to 3 weeks after the end of treatment. Fisher′s exact test was used to analyze factors influencing the treatment outcome. Results:Totally, 36 eligible subjects were enrolled, including 30 males and 6 females. Among them, 18 (50%) patients completed post-treatment etiological assessment, which showed that 12 achieved microbiological cure, and treatment failures occurred in 6; another 18 patients achieved clinical cure. The overall response rate to doxycycline-moxifloacin sequential therapy was 83.3% (30/36, 95% confidence interval[ CI]: 70.5%, 96.1%) . The treatment outcome showed no significant association with the patients′ age, gender, marital status, number of sexual partners in the past 1 month, history of sexually transmitted diseases, history of antibiotic use in the past 1 month, or co-infections (all P > 0.05) . Conclusion:The efficacy of doxycycline-moxifloacin sequential regimen is limited in the treatment of Mycoplasma genitalium infections in Nanjing area, and clinicians should be alerted to the possibility of treatment failure in clinical practice.