Objective To explore the application value of compressed sensing(CS)contrast enhanced 3D fluid attenuated inver-sion recovery(FLAIR)in the detection of tumor brain metastases.Methods Sixty patients with malignant tumors who underwent head MRI enhancement examination were selected.Routine plain scan and contrast enhanced 3D T1 WI were performed first,and CS 3D FLAIR scan was performed 5 min after contrast agent injection.The image quality were graded and the number of lesions were summarized by two senior radiologists.The contrast-to-noise ratio(CNR)of lesions greater than 5 mm was measured.SPSS 22.0 was used for Kruskal-Wallis(H),Mann-Whitney U rank sum and paired t-test analysis,and P＜0.05 was significant difference.Results There were no significant differences in image quality among the 3 sequences(H=3.843,P=0.416).Among 121 brain metastases(n=32),there were 89 lesions detected by routine plain scan,103 lesions detected by contrast enhanced 3D T1WI,and 112 lesions detected by CS 3D FLAIR.Overall comparison of number of lesions with different sizes detected by three sequences was significant difference(H=88.421,P＜0.05).There were statistically significant differences between CS 3D FLAIR and routine plain scan and contrast enhanced 3D T1 WI,respectively(P＜0.05).Conclusion Contrast enhanced 3D FLAIR can better display tumor brain metastases and small metastases in brain parenchy-ma and improve the diagnostic accuracy of brain metastases.Combined with CS technology,it improves scanning speed,which has important clinical value for diagnosing and treat the malignancy.