1.Protective effects of bismuth nitrate against the nephrotoxicity of mercuric chloride and gentamicin.
Hae Young CHUNG ; Jong Deog KIM ; Jeong Sun KIM ; Pil Sun KIM ; Han Suk YOUNG ; Yung Jae RHO ; Suk Soo SUH
Korean Journal of Nephrology 1991;10(1):49-53
No abstract available.
Bismuth*
;
Gentamicins*
;
Mercuric Chloride*
2.Role of resection for Bismuth type IV hilar cholangiocarcinoma and analysis of determining factors for curative resection.
In Woong HAN ; Jin Young JANG ; Mee Joo KANG ; Wooil KWON ; Jae Woo PARK ; Ye Rim CHANG ; Sun Whe KIM
Annals of Surgical Treatment and Research 2014;87(2):87-93
PURPOSE: Extended liver resection may provide long-term survival in selected patients with Bismuth type IV hilar cholangiocarcinoma (HCCA). The purpose of this study was to identify anatomical factors that predict curative-intended resection. METHODS: Thirty-three of 159 patients with Bismuth type IV HCCA underwent major hepato-biliary resection with curative intent (CIR) between 2000 and 2010. Disease extent and anatomical variations were analyzed as factors enabling CIR. RESULTS: CIR ratio with hilar trifurcation bile duct variation (13/16) was significantly higher than that with other bile duct variation types (18/25). Hilum to left second bile duct confluence and tumor infiltration over left second bile duct confluence lengths in right-sided CIR were significantly shorter than those lengths in left-sided CIR (10.8 +/- 4.9 and 2.7 +/- 0.8 mm vs. 16.5 +/- 8.4 and 7.0 +/- 5.3 mm, respectively). Left-sided CIR patients had a marginally higher proportion of tumors invading < or =5 mm over the right second confluence than that in right-sided CIR patients (13/17 vs. 6/16; P = 0.061). The 3-year survival rate after CIR (28%) was significantly higher than after non-CIR (6.1%). CONCLUSION: We recommend the criteria of CIR as bile duct variation type, length of hilum to contralateral second bile duct confluence, and extent of tumor infiltration over the second confluence for Bismuth type IV HCCA.
Bile Ducts
;
Bismuth*
;
Cholangiocarcinoma*
;
Humans
;
Klatskin's Tumor
;
Liver
;
Survival Rate
3.Efficacy and Safety of Albis(R) in Acute and Chronic Patients with Gastritis: A Double-blind, Placebo-controlled, Randomized Multi-center Study.
Hae Won HAN ; Myung Gyu CHOI ; Sang Young SEOL ; Dong Ho LEE ; Hwoon Yong JUNG ; Tae Nyeun KIM ; Suck Chei CHOI ; Hyen Soo KIM
Korean Journal of Gastrointestinal Endoscopy 2011;42(4):215-221
BACKGROUND/AIMS: Albis(R) is a newly developed drug comprised of ranitidine, bismuth and sucralfate. The aim of the study was to demonstrate the efficacy and safety superiority of Albis(R) compared to Stillen(R) for treating erosive gastritis. METHODS: This study was a randomized, double-blind, multi-center trial. The primary endpoint was 2 weeks of treatment. RESULTS: Of the 229 patients in the intention-to-treat (ITT) population, 87 from the Albis(R), and 96 from the Stillen(R) group were included in the per protocol (PP) analysis. The endoscopic improvement rate was not different between the Albis(R)(R) group and the control in both the PP (42.5%, 39.6%) and ITT (35.3%, 34.5%) populations. The endoscopic cure of erosion was also not different in the Albis(R) group than that in the control group in both the PP (32.3%, 31.3%) and ITT (27.6%, 27.4%) populations. The endoscopic improvement rate for hemorrhage, edema, and erythema were also not different between the two groups in both the PP and ITT populations. No statistically significant differences were observed for adverse events between the two groups. CONCLUSIONS: Half of the approved dose of Albis(R) for peptic ulcers was superior to Stillen(R). A low dosage of Albis(R) is more cost efficient and safe than that of Stillen(R).
Bismuth
;
Edema
;
Erythema
;
Hemorrhage
;
Humans
;
Peptic Ulcer
;
Ranitidine
;
Sucralfate
4.Functional Significance of Stress-relieving Act of Chewing and it Effect on Brain Activation by Strees
Masami NIWA ; Itaru HIRAMATSU ; Fumiaki NAKATA ; Chika HAMAYA ; Nobuhito ONOGI ; Koshiro SAITO
Journal of the Japanese Association of Rural Medicine 2005;54(4):661-666
The chewing-related neuronal mechanism underlying stress relief, was evaluated by use of fMRI. For this purpose we examined the effect of chewing a moderately hard gum without any taste (X type, Lotte Co. LTd., Tokyo) on brain activation caused by a noisy sound stress, on plasma levels of catecholamines and ACTH. The stress significantly increased the blood oxygenation level-dependent (BOLD) signals in the amygdala and the medial prefrontal cortex, and elevated plasma levels of noradrenaline, dopamine and ACTH. However, this chewing suppressed not only the stress-induced increase in BOLD signals in these two regions, but also the stress-induced elevation in plasma levels of these catecholamines and ACTH. The results suggested that chewing might be a useful therapy for reducing stress.
Stress
;
Mastication
;
Adrenocorticotropic hormone measurement
;
Plasma
;
Stress bismuth subsalicylate
5.Life Events and Posttraumatic Stress in Hanshin-Awaji Earthquake Victims
Young-Sook KWON ; Soichiro MARUYAMA ; Kanehisa MORIMOTO
Environmental Health and Preventive Medicine 2001;6(2):97-103
Stress induced by disaster is experienced to varying degrees by all respondents, and is known to evoke psychophysiological reactions. In this study, we investigated the relationships between earthquake-related life events and posttraumatic stress symptoms. A total of 380 adults were surveyed one year after the 1995 Hanshin-Awaji earthquake in Japan. The questionnaire included items concerning earthquake-related life events, emotional support and posttraumatic stress disorder (PTSD) symptoms. As a result, after controlling for demographic variables, earthquake-related life events were significantly related to the grade of posttraumatic stress and its three components: re-experience, avoidance and arousal, in both male and female subjects. Male subjects who currently had lower emotional support showed higher scores of posttraumatic stress and arousal. In conclusion, a higher experience of earthquake-related life events appears to be an important risk factor for development of poor mental health status following an earthquake disaster.
Earthquakes
;
Life events
;
seconds
;
Stress bismuth subsalicylate
;
Stress
6.Perturbation of Secretory Ig A in Saliva and Its Daily Variation by Academic Stress
Zhong-Qiu GUO ; Takemi OTSUKI ; Yasuhisa ISHII ; Aya INAGAKI ; Youichiro KAWAKAMI ; Yuki HISANO ; Riichiro YAMASHITA ; Kenta WANI ; Haruko SAKAGUCHI ; Satoshi TSUJITA ; Kanehisa MORIMOTO ; Ayako UEKI
Environmental Health and Preventive Medicine 2001;6(4):268-272
Objectives: Several studies have reported that the secretory immunoglobulin A (S-IgA) concentration in saliva is an indicator of psychological stress. The aim of this study was to clarify the relationship between S-IgA and the stress from academic examinations. Methods: S-IgA levels in 10 medical student volunteers from the second year course between May 4 and July 13, 2000 were examined using the ELISA method. Results: There was a tendency for S-IgA in saliva to be higher on the day before academic examinations and during them, and lower on the days between these examinations. Conclusions: It may be possible to use this measurement to monitor psychological stress in students and workers.
Upper case ess
;
Immunoglobulin A measurement
;
Saliva
;
Stress bismuth subsalicylate
;
Daily
7.Comparison of the Efficacy of Bismuth Containing PPI-based Quadruple Therapy with PPI-based Triple Therapy Only as First-line Treatment for Helicobacter pylori Infection.
Hyun Jin JO ; Dong Ho LEE ; Seung Joo KANG ; Mi Na KIM ; Su Hyun KIM ; Jin Myung PARK ; Mun Sun CHOI ; Hyun Chae JUNG ; In Sung SONG ; Nayoung KIM ; Sook Hyang JUNG ; Jin Wook KIM ; Young Soo PARK ; Sang Hyub LEE
Korean Journal of Gastrointestinal Endoscopy 2008;37(4):259-264
BACKGROUND/AIMS: In recent years, increasing antimicrobial resistance has resulted in falling eradication rates with standard therapies. To overcome the falling eradication rates, rescue therapy have been suggested to be used. However, there is no surveillance of using bismuth-based regimen as first line Helicobacter pylori eradication therapy in Korea. This study aimed to assess the efficacy of bismuth containing PPI-based quadruple therapy as a first line treatment. METHODS: From August 2007 through February 2008, 191 patients with Helicobacter pylori positive peptic ulcer disease (PUD) or chronic gastritis (CG) who received first line therapy for 7 days were retrospectively evaluated. 39, 37, 53, 62 patients received PAC (pantoprazole 40 mg, amoxicillin 1 g, clarithromycin 500 mg bid), L-PAC (pantoprazole 40 mg, amoxicillin 750 mg, clarithromycin 250 mg bid), PACB (PAC plus bismuth 300 mg bid), L-PACB (L-PAC plus bismuth 300 mg bid). RESULTS: There was no significant difference in eradication rates between bismuth containing and non- containing group. However, in PUD, the eradication rate of PACB (95.2%) is somewhat higher than that of PAC (86.2%) without statistical significance. CONCLUSIONS: In PUD, Future study designed with a double-blind controlled large scale might reveal that PPI-based standard quadruple therapy containing a bismuth is superior to the standard triple therapy.
Amoxicillin
;
Bismuth
;
Clarithromycin
;
Gastritis
;
Helicobacter
;
Helicobacter pylori
;
Humans
;
Korea
;
Peptic Ulcer
;
Retrospective Studies
8.Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted.
Jayant P TALREJA ; Marisa DEGAETANI ; Kristi ELLEN ; Timothy SCHMITT ; Monica GAIDHANE ; Michel KAHALEH
Clinical Endoscopy 2013;46(4):390-394
BACKGROUND/AIMS: Photodynamic therapy (PDT) in unresectable cholangiocarcinoma has been associated with improved survival. We report a single tertiary care center experience over the past 6 years. METHODS: Fifty-five patients with unresectable cholangiocarcinoma received PDT between 2004 and 2010. Plastic stents were placed after PDT to prevent cholangitis. RESULTS: Twenty-seven patients (49%) showed Bismuth type IV, 22 (41%) showed Bismuth type III, and six (10%) showed Bismuth type I and II. Twenty patients (37%) received chemotherapy and radiation therapy, five (9%) received chemotherapy only; and one (2%) received radiation therapy only. Mean number of PDT sessions was 1.9+/-1.5 sessions (range, 1 to 9). Mean survival duration was 293+/-266 days (median, 190; range, 25 to 1,332). PDT related complications included three (5%) facial burn, three (5%) photosensitivity, and two (3%) rash. Kaplan-Meier analysis comparing the survival means of patients who received PDT and chemotherapy/radiation therapy (median survival 257 days; 95% confidence interval [CI], 166 to 528) versus who received PDT only (median survival 183 days; 95% CI, 129 to 224) showed no significant difference (log-rank p=0.20). CONCLUSIONS: PDT has a measurable impact on survival in unresectable cholangiocarcinoma but requires aggressive stenting posttherapy.
Bismuth
;
Burns
;
Cholangiocarcinoma
;
Exanthema
;
Humans
;
Kaplan-Meier Estimate
;
Photochemotherapy
;
Plastics
;
Stents
;
Tertiary Care Centers
;
Triazenes
9.Metronidazole Resistance and the Eradication of Helicobacter pylori.
Gwang Ho MUN ; Joon Soo HAHM ; Kwang Hyun RYU ; Oh Young LEE ; Dong Soo HAN ; Byung Chul YOON ; Ho Soon CHOI ; Min Ho LEE ; Choon Suhk LEE ; Kyung Nam PARK ; Jung Ok KANG
Korean Journal of Gastrointestinal Endoscopy 1998;18(6):847-852
BACKGROUND/AIMS: The success of Helicobacter pylori eradication is limited by antibiotic resistances, and the primary resistance to metranidazole seems to be high. In this study, the frequency af metronidazole resistance and the eradication rate in metronidazole-resistant H. pylori strain was evaluated. METHODS: Sixty-eight patients were tested for metronidazole resistance using microdilution broth, the E test and disk diffusion method. Twenty-two patients were treated for 14 days with amoxicilline 2000 mg, metronidazole 750 mg, and tripotassium dicitrate bismuth 1200 mg. RESULTS: Metronida-zole resistance was 46% (31/68). The eradication rates for H. pylori was 91.7% in patients with metronidazole-sensistive strains and 70% in patients with metronidazole-resistant strains. CONCLUSIONS: Metronidazole resistance was high (46%) in Korea, however, triple therapy was an efficient method of eradicating H. pylori in both metronidazole sensitive and resistant strains.
Amoxicillin
;
Bismuth
;
Diffusion
;
Helicobacter pylori*
;
Helicobacter*
;
Humans
;
Korea
;
Metronidazole*
;
Peptic Ulcer
10.Eradication Rates of First-line and Second-line Therapy for Helicobacter pylori Infection in Gyeongnam Province.
Gyo Hui KIM ; Jin Ah KIM ; Ui Won KO ; Jong Ho PARK ; Jue Yong LEE ; Su Sin JIN ; Yeon Ho JOO ; Jae Uk SHIN
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2015;15(3):160-165
BACKGROUND/AIMS: The eradication rates of Helicobacter pylori has been decreasing over the years and it is different among the regions. The aim of this study was to investigate the rates of first-line and the second-line eradication of H. pylori over the last 5 years in a single institute of Changwon and Gyeongsangnam-do, Korea. MATERIALS AND METHODS: Eradication rates of first-line triple regimen in 1,164 patients and second-line quadruple regimen in 223 patients who received H. pylori eradication treatment from January 2008 to December 2012 at Changwon Fatima Hospital were evaluated retrospectively. The patients for second-line quadruple therapy were divided into three groups according to the dosage of medications. RESULTS: The overall eradication rates of first-line and second-line therapy were 70.5% and 81.2%, respectively. There was no decreasing tendency in the eradication rate of first-line therapy for 5 years (P=0.573). However, annul eradication rates of second-line therapy significantly decreased (P=0.001, linear by linear association). In second-line therapy, patients treated with high dose bismuth and metronidazole had higher eradication rates than those treated with low dose bismuth and metronidazole (P=0.039). CONCLUSIONS: The effectiveness of the first-line and second-line therapy for H. pylori was suboptimal. In addition, there was a decreasing tendency in the eradication rates of second-line therapy over the past 5 years in Changwon and Gyeongsangnam-do province. Alternative regimens or high dose therapy should be considered for first-line and second-line therapy.
Bismuth
;
Gyeongsangnam-do
;
Helicobacter pylori*
;
Helicobacter*
;
Humans
;
Korea
;
Metronidazole
;
Retrospective Studies