ObjectiveTo observe the effect of interlimb-coordinated training on pulmonary function in patients with early primary Parkinson's disease. MethodsFrom February, 2021 to February, 2022, 60 patients with primary Parkinson's disease in Affiliated Hospital of Southwest Medical University were divided into control group (n = 30) and experimental group (n = 30) according to the management, who accepted medicine and medicine combined with interlimb-coordinated training, for twelve weeks, respectively. Before and after treatment, the forced expiratory volume in the first second (FEV₁), forced vital capacity (FVC), maximum expiratory flow (PEF) and vital capacity (VC) were measured with pulmonary function instrument, while the peak oxygen uptake (VO_2peak), anaerobic threshold (AT) and peak power (WR_peak) were measured with Cardiopulmonary Exercise Test (CPET), and the maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) were measured with respiratory driving instrument. ResultsAfter treatment, FEV₁, FVC, PEF, VC, VO_2peak, AT, WR_peak, MIP and MEP increased in the experimental group (t > 2.087, P < 0.05), and they were more in the experimental group than in the control group (t > 2.079, P < 0.05). ConclusionInterlimb-coordinated training could improve the pulmonary function, aerobic exercise ability and respiratory muscle strength of patients with early primary Parkinson's disease.

ObjectiveTo systematically evaluate the effects of threshold inspiratory muscle training (TIMT) on respiratory function, motor function and quality of life in patients with chronic obstructive pulmonary disease (COPD). MethodsRandomized controlled trials (RCT) about the effects of TIMT on dyspnea, quality of life, motor function and inspiratory muscle strength for COPD patients were retrieved from PubMed, EBSCO, Web of Science, Ovid, Cochrane Library, SinoMed, CNKI, VIP, since establishment to September, 2020. Two researchers independently screened literatures, extracted data and evaluated the methodological quality. A meta-analysis was performed using RevMan 5.3. ResultsA total of 30 RCTs involving 2 060 patients were included. TIMT could obviously improve the maximum inspiratory pressure (MD = 10.68, 95%CI 7.43 to 13.92, P < 0.001), optimize the results of 6-minute Walking Test (MD = 24.62, 95%CI 9.09 to 40.15, P = 0.002), the St George's Respiratory Questionnaire (MD = -3.08, 95%CI -5.84 to -0.33, P = 0.03), the modified Medical Research Council Dyspnea Scale (MD = -0.30, 95%CI -0.52 to -0.07, P = 0.01) and Borg score (MD = -0.84, 95%CI -1.24 to -0.44, P < 0.001). TIMT could also improve the forced expiratory volume in one second (MD = 0.11, 95%CI 0.04 to 0.19, P = 0.003) and the forced expiratory volume in one second in predicted (MD = 3.72, 95%CI 2.62 to 4.82, P < 0.001). There was no significant difference in the COPD Assessment Test (MD = -1.14, 95%CI -2.32 to 0.03, P = 0.06) or forced vital capacity (MD = 0.07, 95%CI -0.12 to 0.25, P = 0.49). ConclusionTIMT can improve the inspiratory muscle strength, alleviate the symptoms of dyspnea, and improve the lung function and the quality of life for COPD patients.