Objective To investigate the effects of house modification on quality of life and activities of daily living of discharged patients with spinal cord injury. Methods 65 patients with spinal cord injury were followed up. Among them, 31 patients accepted house modification (observation group), and 34 did not (control group). Both groups accepted routinely rehabilitation direction after discharge. They were assessed with Barthel index and World Health Organization Quality of Life Brief Form (WHO QOL-BRIEF) 1 and 3 months after discharge.Results The score of QOL and BI improved more in the observation group than in the control group (P<0.05). Conclusion House modification can improve the quality of life and activities of daily living for patients with spinal cord injury.