Biopsy ; adverse effects ; Breast ; pathology ; radiation effects ; Breast Implantation ; adverse effects ; Breast Neoplasms ; drug therapy ; radiotherapy ; Drug-Related Side Effects and Adverse Reactions ; etiology ; Female ; Humans ; Iatrogenic Disease

The diagnosis of exogenous ochronosis is often challenging and requires a high index of suspicion. Herein, we report a case of exogenous ochronosis in a Chinese patient. The condition was caused by the use of bleaching agents, including creams containing hydroquinone. We demonstrate the use of dermoscopy as an invaluable tool for the early recognition of the condition, as well as in the selection of an appropriate site for a skin biopsy.
Alkaptonuria ; Biopsy ; Bleaching Agents ; adverse effects ; China ; Dermoscopy ; methods ; Humans ; Hydroquinones ; adverse effects ; Male ; Melanosis ; drug therapy ; Middle Aged ; Ochronosis ; diagnosis ; therapy ; Skin ; drug effects ; pathology ; Treatment Outcome

No abstract available.
Biopsy, Fine-Needle/*adverse effects ; Carcinoma, Hepatocellular/*secondary ; Female ; Humans ; Liver Neoplasms/*pathology ; Male ; *Neoplasm Seeding

OBJECTIVESTo probe into the complications of prostate biopsy.

METHODSThe clinical data of 220 patients underwent prostate biopsy from 1997 to 2001 were reviewed.

RESULTSA total of 93 patients suffered slight complications, and 15 patients suffered severe complications.

CONCLUSIONSTransrectal prostate biopsy is easily and safely by using 18 gague biopsy needles. These data demonstrate the low morbidity and less complication associated with contemporary transrectal prostate biopsy.

Aged ; Aged, 80 and over ; Biopsy, Needle ; adverse effects ; Humans ; Male ; Middle Aged ; Prostate ; pathology

Adult ; Aneurysm, False ; etiology ; Arteriovenous Fistula ; etiology ; Biopsy ; adverse effects ; Humans ; Kidney ; surgery ; Male ; Postoperative Complications

Biopsy, Fine-Needle ; Bronchi ; diagnostic imaging ; pathology ; Endosonography ; adverse effects ; methods ; Humans ; Thoracic Neoplasms ; diagnostic imaging

OBJECTIVETo compare the difference of mucosal damage in the remnant esophagus with similar postoperative reflux after esophagectomy and gastric interposition between Chinese and Canadian population.

METHODSA prospective 1 to 1 paired study based on the same surgical approach was performed in Medical Centre of University of Montreal and West China Hospital of Sichuan University during the period from September 2010 to October 2013. The patients were followed up and evaluated by reflux symptom scoring, endoscopic assessment of mucosal damage, pathologic examination of biopsies and proliferation index test of esophageal epithelium.

RESULTSEighteen Han Chinese and 18 Caucasian Canadian patients with esophagectomy and gastric interposition were included in this study, with a follow-up period of 45 (28-67) months. There were no significant differences between the two groups in the incidence of postoperative reflux symptom, reflux symptom scoring, histological reflux esophagitis, erosion or stricture of remnant esophagus (all P>0.05). However, the incidence of mucosal metaplasia [44.4% (8/18) versus 11.1% (2/18), P=0.026], quantitative MUSE scoring [1.5 (1.0-2.0) versus 1.0 (0-2.0), P=0.042] and proliferation index [0.40 (0.30-0.45) versus 0.35 (0.30-0.50), P=0.038] of esophageal epithelium were significantly higher in Canadian patients than those in Chinese patients.

CONCLUSIONUnder similar reflux situation, esophageal mucosa of Canadian population is more sensitive to the gastroesophageal reflux damage compared with Chinese population, resulting in more severe reflux damage of remnant esophagus in Canadian patients.

Biopsy ; Canada ; China ; Esophagectomy ; adverse effects ; Gastroesophageal Reflux ; pathology ; Humans ; Metaplasia ; Mucous Membrane ; pathology ; Prospective Studies

Adult ; Biopsy ; Donor Selection ; Humans ; Liver ; pathology ; Liver Transplantation ; adverse effects ; pathology ; Living Donors ; Postoperative Complications

Drug-induced liver injury (DILI) remains a significant clinical challenge and is the leading cause of acute liver failure in most countries. An aging population that uses more medications, a constant influx of newly developed drugs and a growing risk from unfamiliar herbal and dietary supplements will make DILI an increasing part of clinical practice. Currently, the most effective strategy for disease management is rapid identification, withholding the inciting agents, supportive care and having a firm understanding of the expected natural history. There are resources available to aid the clinician, including a new online "textbook" as well as causality assessment tools, but a heightened awareness of risk and the disease's varying phenotypes and good history-taking remain cornerstones to diagnosis. Looking ahead, growing registries of cases, pharmacoepidemiology studies and translational research into the mechanisms of injury may produce better diagnostic tools, markers for risk and disease, and prevention and therapeutics.
Age Factors ; Anti-Infective Agents/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anticonvulsants/adverse effects ; Biopsy ; Dietary Supplements/adverse effects ; Drug-Induced Liver Injury/*diagnosis/epidemiology ; Drugs, Chinese Herbal/adverse effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Incidence ; Liver/pathology ; Liver Function Tests ; Risk Factors ; Tumor Necrosis Factor-alpha/antagonists & inhibitors

A 69-year-old male was diagnosed in February 2004 with stage IV extranodal marginal zone B cell lymphoma involving the mediastinal nodes, lung parenchyma and bone marrow with high LDH. Shortness of breath developed following the 5th course of Rituximab-CHOP chemotherapy (cyclophosphamide, Vincristine, Doxorubicin, Prednisolone). Bronchoscopy guided transbronchial lung biopsy revealed interstitial thickening and type II pneumocyte activation, compatible with interstitial pneumonitis. After treatment with prednisolone a complete resolution of the dyspnea was observed. The patient was well on routine follow-up at the outpatient clinic, with no progression of lymphoma or interstitial pneumonitis.
Aged ; Antibodies, Monoclonal/*adverse effects/*therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/*adverse effects/*therapeutic use ; Biopsy ; Cyclophosphamide/adverse effects/therapeutic use ; Doxorubicin/adverse effects/therapeutic use ; Humans ; Lung Diseases, Interstitial/*chemically induced/*pathology/radiography/surgery ; Lymphoma, B-Cell, Marginal Zone/*drug therapy ; Male ; Prednisone/adverse effects/therapeutic use ; Tomography, X-Ray Computed ; Vincristine/adverse effects/therapeutic use