No abstract available.
Biomarkers, Tumor

Numerous tumor markers have been investigated and have been in clinical use for the management of cancer patients. Among them, carcimoembryonic antigen(CEA), CA19-9, and CA125 are the most commonly used tumor markers in periampullary cancer. We carried out this study to estimate the usefulness of these three tumor markers in the management of periampullary cancer. The serum levels of CEA, CA19-9, and CA125 were measured in 55 patients between Jan. 1990 and Feb. 1997. We also valuated the changes in the levels of these three tumor markers after surgery. The serum level of CEA was elevated in 30 patients(60%) preoperatively. The serum level of CA19-9 was elevated in 38 patients(83%), and the serum CA125 level was elevated in 13 patients(59%) preoperatively. The CA19-9 levels decreased in 20(95%) of 21 patients who had received a tumor resection, while only one of those patients had an elevated level of serum CA19-9 postoperatively. Similarly, the CEA levels decreased in 23(88%) of 26 patients who had received a tumor resection. The mean level of CA19-9 has higher in advanced stages than in early stages, but this difference was not statistically significant. In conclusion, there was no single reliable tumor marker in periampullary cancer. However, CA19-9 was the most sensitive tumor marker among the three.
Biomarkers, Tumor ; Humans

No abstract available.
Stomach Neoplasms* ; Biomarkers, Tumor*

No abstract available.
Humans ; Biomarkers, Tumor*

We measured serum levels of CA-125 and Tissue polypeptide antigen(TPA) in 135 patients with pelvic tumors(129 benign pelvic tumors and 6 malignant ovarian tumors) preoperatively. Each tumor marker was measured by immunoradiometric assay. Serum CA-125 levels of 35.0U/ml, 65.0U/ml and TPA levels of 80.0U/ml, 100.0U/ml were determined as cut-off values. The results were evaluated by each tumor marker and two tumor markers coincidently. The results were as follows : (continue)
Humans ; Immunoradiometric Assay ; Biomarkers, Tumor

Biomarkers, Tumor ; Humans ; Lymphoma ; Prognosis

No abstract available.
Humans ; Biomarkers, Tumor* ; Uterine Cervical Neoplasms*

Quantum dots, as a new kind of biological fluorescence material, have properties superior to the traditional organic dyes. In the recent decade, researches about the application of quantum dots in biomedicine have made great progress. Tumor markers have vital importance in the diagnosis and treatment of carcinoma; however, they are not widely used for lack of specificity and sensitivity. Researches about applications of quantum dots in the detection of tumor markers are centralized in three aspects, namely the detection of serum/plasma tumor markers, the detection of tissue and cell tumor markers (such as molecular imaging of cell and tissue), and the detection of tumor in vivo animals. A combination of quantum dots and flow cytometry technique for developing a new technique to detect multiple kinds of tumor markers at the same time with greater sensitivity, specificity, rapidity and convenience may have the potential for clinical use of quantum dots.
Biomarkers, Tumor ; analysis ; Humans ; Quantum Dots

Today, the comprehensive surgical treatment for gastrointestinal cancer is almost in the perfect stage. It is difficult to further improve the curative effect by surgery only. To improve the overall curative effect of gastrointestinal tumor, translational medicine research should be promoted in the fields of the early diagnosis, etiology and pathogenesis and comprehensive treatment. Researches of discovering the new tumor markers for early diagnosis of tumor, etiology and pathogenesis involve many aspects, including environmental factors, genetic susceptibility, variation and accumulation of genetics, and epigenetic changes, which should be transferred to new methods of treatment. This review summarizes the gastrointestinal tumor-associated hot topics in the field of basic research and its progress, and provides the clinical clues from their conversion.
Biomarkers, Tumor ; Gastrointestinal Neoplasms ; diagnosis ; genetics ; Humans

The development of cancer biomarkers has brought the treatment of cancer from the tumor type-based to molecular target-based,and the latter marks the introduction of personalized cancer medicine (PCM). However,each individual tumor has unique molecular information,and the real PCM should be focused on single individuals and their specific molecular identities.
Biomarkers, Tumor ; Humans ; Neoplasms ; Precision Medicine