1.Chemical and pharmacological progress on usnic acid and its derivatives.
Sha-Na WUKEN ; Shun-Gang JIAO ; Xin-Yao YANG ; Xiao-Li GAO ; Chang-Hai QU ; Qian ZHANG ; Chun-Sheng LIU ; Peng-Fei TU ; Xing-Yun CHAI
China Journal of Chinese Materia Medica 2018;43(19):3811-3821
Usnic acid and its derivatives, a group of organic molecules with great importance, are characteristic to lichens, possessing pharmacological activities such as anti-virus, anti-bacteria, anti-humor, anti-inflammatory, analgesic, and anaesthetic effects. Many of them have been widely used as medicine, but also bring side effects such as dermatitis and liver damages. In the past decades, great efforts by isolation, organic synthesis, and structure modification methods were put on discovery of UA derivatives with higher biological activities or less side effects. This paper describes herein the most progress on natural sources, isolation and structure elucidation, structural characteristics, synthesis and modification results, pharmacological activities and toxicities of UA and its derivatives, hopefully to provide valuable reference for further research.
Benzofurans
;
chemistry
;
pharmacology
;
Biological Products
;
Lichens
;
chemistry
2.Natural products chemistry research 2010's progress in China.
Yang YE ; Xi-Qiang LI ; Chun-Ping TANG ; Sheng YAO
Chinese Journal of Natural Medicines (English Ed.) 2012;10(1):1-13
This article reviews the progresses made by Chinese scientists in the field of natural products chemistry in 2010. Selected compounds with unique structural features and/or promising bioactivities were described herein on the basis of structural types.
Biological Products
;
chemistry
;
pharmacology
;
China
;
Humans
;
Molecular Structure
;
Research
3.Advances in the role of natural products in human gene expression.
Gang CHEN ; Di ZHOU ; Cheng-Min WANG ; Ning LI
Chinese Journal of Natural Medicines (English Ed.) 2022;20(1):1-8
Natural products (NPs), especially those from traditional herbal medicines, can evidently modulate human gene expression at multiple levels, leading to a wide diversity of bioactivities. Although numerous bio-functions of NPs for human body have been found, there is little understanding about how NPs achieve it, as less attention was drawn to the definite mechnism by which NPs regulate gene expression. Furthermore, based on the rapidly advancing knowledge of mechanisms for gene regulation in recent years, newly-understood mechanisms, such as post-transcriptional regulation, are found to be involved in NP-elicited bio-effects, providing a new perspective on understanding the role of NPs in gene expression. Therefore, in the current review, we summarize the function of NPs in gene expression from the perspectives of transcriptional, post-transcriptional, and post-translational regulation, which will reinforce the understanding of NP-induced effects in gene expression and facilitate the exploration of more NPs with potential therapeutic effects.
Biological Products/pharmacology*
;
Gene Expression
;
Gene Expression Regulation
;
Humans
4.Research progress on natural products of fungi of Diaporthe sp.
Jia CAI ; Wen-Ying ZHOU ; Guang-Ming XU ; Xiao-Jiang ZHOU
China Journal of Chinese Materia Medica 2021;46(7):1717-1726
Diaporthe sp. fungi is one of the important sources of active natural products. Polyketides, alkaloids, terpenes, anthraquinones and other types of novel metabolic products are found from this genus, and many of them have significant anti-tumor, antibacterial, anti-hyperlipidemia, inhibition of pulmonary fibrosis, antioxidant and other biological activities. This paper reviewed source, structure and biological activity of natural products from Diaporthe sp. in the past two decades, and provided a reference for in-depth study of natural product of this genus fungus and innovative drug development.
Anti-Bacterial Agents
;
Biological Products/pharmacology*
;
Fungi
;
Polyketides
;
Terpenes
5.Research on anti-tumor natural product diosgenin.
Shi-Qing ZHANG ; Yu-Xuan SONG ; Wen-Xue ZHANG ; Ming-Jun CHEN ; Shu-Li MAN
China Journal of Chinese Materia Medica 2021;46(17):4360-4366
Diosgenin is widely distributed in many plants, such as Polygonatum sibiricum, Paris polyphylla, Dioscorea oppositifolia, Trigonella foenum-graecum, Costus speciosus, Tacca chantrieri, which has good anti-tumor activity and preferable effects on preventing atherosclerosis, protecting the heart, treating diabetes, etc. This review combed through the anti-tumor mechanisms of diosgenin encompassing lung, breast, gallbladder, liver, oral cavity, stomach, bladder, bone marrow, etc. Besides, it was discovered that diosgenin mainly exerts its effect by inhibiting tumor cell migration, suppressing tumor cell proliferation and growth, and inducing cell apoptosis. However, problems like low yield and bioavailability frequently exist in natural diosgenin. This review introduced methods such as structural modification, dosage form optimization and combination medication to improve the yield and anti-tumor activity of diosgenin. Via the summary of this paper, it is expected to provide theoretical basis for the rational exploitation and utilization of diosgenin.
Apoptosis
;
Biological Products
;
Cell Proliferation
;
Diosgenin/pharmacology*
;
Trigonella
6.Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities.
Bo-Ru CHEN ; Cheng-Long GAO ; Jin LIU ; Yue-Wei GUO ; Jian-Lan JIANG ; Tao PANG ; Xu-Wen LI
Chinese Journal of Natural Medicines (English Ed.) 2022;20(1):74-80
Diversity-oriented synthesis is aimed to increase the chemical diversity of target natural products for extensive biological activity evaluation. Indole ring is an important functional group in a large number of drugs and other biologically active agents, and indole-containing natural products have been frequently isolated from marine sources in recent years. In this paper, a series of indole-containing marine natural hyrtioreticulin derivatives, including 19 new ones, were designed, synthesized through a key Pictet-Spengler reaction, and evaluated for their inflammation related activity. Compound 13b displayed the most promising activity by inhibiting TNF-α cytokine release with an inhibitory rate of 92% at a concentration of 20 μmol·L-1. A preliminary structure-activity relationship analysis was also discussed. This research may throw light on the discovery of marine indole alkaloid derived anti-inflammatory drug leads.
Animals
;
Anti-Inflammatory Agents/pharmacology*
;
Biological Products/pharmacology*
;
Indole Alkaloids/pharmacology*
;
Porifera
;
Structure-Activity Relationship
7.Progress in metabolism studies of bioactive components from Chinese medicinal natural products.
China Journal of Chinese Materia Medica 2010;35(23):3223-3232
Major pathways of drug metabolism have been introduced in the article. Studies on the metabolism of bioactive components from Chinese medicinal natural products have been summarized. Finally, personal hope for domestic scientists has been put forward.
Animals
;
Biological Products
;
metabolism
;
pharmacology
;
Drugs, Chinese Herbal
;
metabolism
;
pharmacology
;
Humans
;
Medicine, Chinese Traditional
8.Research progress of the natural small molecular products synergistically with antifungal agents to inhibit drug-resistant fungi.
Shan-Lun TAN ; Da-Zhi ZHANG ; Yuan-Ying JIANG
Acta Pharmaceutica Sinica 2014;49(8):1097-1104
The incidence of systemic fungal infections have increased dramatically, moreover, drug resistance including either primary (intrinsic) or secondary (acquired) resistance, becomes one of the main reasons accounting for the failure of treating invasive fungal infections in the past decades. Nowadays, clinically available antifungal drugs are limited and their combination in antifungal therapy was not effective. It is expected to be a new strategy to synergistically sensitize antifungal drugs against drug-resistant fungi by using new small molecules. Based on the study in our research group and the reported work of others, we reviewed the research of the natural products which have synergistic effect with the antifungal agents against drug-resistant fungi. This review focused on the resource, structure, pharmacological activity, and action mechanism of the compounds, as well as somewhat in common, and would provide theoretical base for seeking new drug against drug-resistance fungi.
Antifungal Agents
;
chemistry
;
pharmacology
;
Biological Products
;
chemistry
;
pharmacology
;
Drug Synergism
;
Fungi
;
drug effects
9.Research advancement in natural anti-cancer product.
Jie YIN ; Qi LI ; Li-Dong SUN ; Qing YANG ; Zheng ZHAO ; Qing-Sen RAN ; Xiao-Gang WENG ; Ying CHEN ; Ya-Jie WANG ; Yu-Jie LI ; Wei-Yan CAI ; Xiao-Xin ZHU
China Journal of Chinese Materia Medica 2019;44(1):19-27
Human health has been severely threatened by malignant tumors continuously.Rational and effective drug use provides an effective means for the treatment of malignant tumors,and is expected to become an important way to solve the problem of tumor treatment in the future.In recent years,with the escalation of new cancer theories and the emergence of clinical drug resistance,innovative research and development of anti-cancer drugs has always been a hot spot and focus in cancer research.Among them,the discovery of novel anti-cancer drugs from natural compound is of top priority due to its strong anti-cancer efficacy and the abundant drug resources.Therefore,it is imperative to systematically summarize the cutting-edge advancements of the natural products and their potential pharmacological mechanisms according to the characteristics of tumor progression,and put forward the new directions and trends for further development of anti-cancer natural products in the future.Specifically,the research advancements on anti-cancer effect of natural products were reviewed,focusing on both the traditional and innovative application.We hope this review could bring the light on the research path of the natural anti-cancer products clearly and comprehensively,and also provide inspirations for innovative,safer and more effective anti-cancer drug development and exploration.
Antineoplastic Agents
;
pharmacology
;
Biological Products
;
pharmacology
;
Humans
;
Neoplasms
;
drug therapy
;
Research
10.Recent progress on anti-Candida natural products.
Fu-Juan SUN ; Min LI ; Liang GU ; Ming-Ling WANG ; Ming-Hua YANG
Chinese Journal of Natural Medicines (English Ed.) 2021;19(8):561-579
Candida is an intractable life-threatening pathogen. Candida infection is extremely difficult to eradicate, and thus is the major cause of morbidity and mortality in immunocompromised individuals. Morevover, the rapid spread of drug-resistant fungi has led to significant decreases in the therapeutic effects of clinical drugs. New anti-Candida agents are urgently needed to solve the complicated medical problem. Natural products with intricate structures have attracted great attention of researchers who make every endeavor to discover leading compounds for antifungal agents. Their novel mechanisms and diverse modes of action expand the variety of fungistatic agents and reduce the emergence of drug resistance. In recent decades, considerable effort has been devoted to finding unique antifungal agents from nature and revealing their unusual mechanisms, which results in important progress on the development of new antifungals, such as the novel cell wall inhibitors YW3548 and SCY-078 which are being tested in clinical trials. This review will present a brief summary on the landscape of anti-Candida natural products within the last decade. We will also discuss in-depth the research progress on diverse natural fungistatic agents along with their novel mechanisms.
Antifungal Agents/pharmacology*
;
Biological Products/pharmacology*
;
Candida/drug effects*
;
Candidiasis/drug therapy*
;
Humans
;
Microbial Sensitivity Tests