The new flavonoid was isolated from the leaves of clerodendron fragrans Vent. Its structure was confirmed by various spectrum of IR, UV, MS, 1H, C13-NMR, DEPT, COSY as 5, 7, 8-trihydroxy-4, -methoxy flavone (I). That flavonoid composition presented good antioxiadant activity. Its effect on cathepsin activity in human blood was studied and showed that flavonoid increased cathepsin activity at optimum concentration.
Biological Factors ; Clerodendrum

No abstract available.
Arthritis, Rheumatoid* ; Biological Factors

Through the research result of 50 elderly peoples have practised relaxation we draw the following conclusion: 1. Traditional medicine’s relaxing practice has its effect to several biological indexes: *Electrict: -On ECG: the alpha wave increases in frequency, amplitude, indexes. The beta index reduces. The theta wave remains in charged. - On REG: The cardiac rhythm decreases and QT wave becomes longer but this change is not significant. *Respiratory: relaxation does not change the breath frequency and oxygen saturation (SaO2) * Circulation relaxation reduces pulse frequency, blood pressure (but still within normal unit), increases blood influx of limbs.* On Hop coc and Tuc tam ly points: The skin temperature increases, skin resistant decreases, no change with electric influx. On some biochemical indexes. Relaxation reduces sugar, cholesterol, triglycerid, cortison, catecholamin. 2. The change of some biochemical indexes mentioned above helps prove scientifically the effect of relaxation practice.
Medicine, Traditional ; Biological Factors ; Aged

Background: Suicide among adolescents is a critical global health problem. Identifying risk factors for suicide in adolescents is crucial because it is one of the most severe mental health issues and can result in loss of life. Risk factors serve as indicators that have the potential to bring life to an end. However, people around adolescents often display indifference and even tend to overlook the suicide risk factors experienced by them. Objective: This study aimed to explore the risk factors for suicide in adolescents in Indonesia. Methods: This study used qualitative descriptive research design conducted at State Vocational High Schools (SMKN) and Puskesmas. Data collection was done through Focus Group Discussion (FGD) of 10 students, and in-depth interviews of eight participants (two parents of adolescents who attempted suicide, two guidance counseling teachers, two adolescents who attempted suicide, and two mental nurses) The data were analyzed using thematic analysis. Results: The risk factors for suicide experienced by adolescents are biological, psychological, and social factors. These risk factors for suicide are stressors that contribute to adolescents engaging in suicidal behavior. Identifying the risk factors experienced by adolescents is crucial for suicide prevention. Conclusion The risk factors that lead to suicide in adolescents encompass biological, psychological, and social factors. A thorough understanding of suicide among parents, teachers, and peers can significantly assist in implementing suitable prevention measures and interventions for adolescent suicide.
Adolescent ; Risk Factors ; Biological Factors ; Psychology ; Social Factors ; Suicide

The study was carried out in Hoan Kiem and Soc Son District in Hanoi city. In each area, 160 women were selected and divided into 4 groups: The menopause of 5 years, > 5-10 years, >10 years and group of 25- 39 years. Vein blood were taken for measurement of alkaline phosphatase activity and osteocalcin concentration. Hungry urine was collected was to determine urinary calcium and creatinin levels, calcium/creatinin ratio. The results showed that: - Serum osteocalcin and alkaline phosphatase which were biological markers of bone formation significantly increased in menopausal women and then decreased. Urinary calcium level and calcium/creatinin ratio of the Hoan Kiem women were higher than Soc Son ones.
Premenopause ; Women ; Biological Factors ; Bone and bones

Remarkable progresses have been achieved regarding the understanding of the neurobiological bases of pain and depression. The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression. With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches. This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.
Biological Factors ; Depression* ; Molecular Biology ; Neurotransmitter Agents

No abstract available.
Arthritis, Rheumatoid* ; Biological Factors* ; Herpes Zoster* ; Incidence*

OBJECTIVE: Failure of first-line anti-tumor necrosis factor (TNF) agents in in rheumatoid arthritis patients leads to decisions among second-line biologic agents. To better inform these decisions, the therapeutic effectiveness of rituximab is compared with other second-line biologic agents in this observational study. METHODS: Between November 2011 and December 2014, study subjects were observed for 12 month periods. Patients with an inadequate response to initial anti-TNF agent received either rituximab or alternative anti-TNF agents (adalimumab/etanercept/infliximab) based on the preference of patients and physicians. The efficacy end point of this study was the change in 28-joint count Disease Activity Score (DAS28) at six and 12 months from baseline. Safety data were also collected. RESULTS: Ninety patients were enrolled in the study. DAS28 at six months did not change significantly whether the patients were treated with rituximab or alternative anti-TNF agents in intention-to-treat analysis (n=34, −1.63±0.30 vs. n=31, −2.05±0.34) and standard population set analysis (n=31, −1.51±0.29 vs. n=24, −2.21±0.34). Similarly, the change in DAS28 at 12 months did not reach statistical significance (−1.82±0.35 in the rituximab vs. −2.34±0.44 in the alternative anti-TNF agents, p=0.2390). Furthermore, the incidences of adverse events were similar between two groups (23.5% for rituximab group vs. 25.8% for alternative anti-TNF agents group, p=0.7851). CONCLUSION: Despite the limitations of our study, switching to rituximab or alternative anti-TNF agents after failure of the initial TNF antagonist showed no significant therapeutic difference in DAS28 reduction.
Arthritis, Rheumatoid* ; Biological Factors ; Biological Products* ; Humans ; Incidence ; Necrosis* ; Observational Study* ; Rituximab*

BACKGROUND: Drug survival, defined as the time until discontinuation, is a parameter reflecting real-world therapeutic effectiveness. Few studies have examined the influence of economic factors on the drug survival of biologic agents for psoriasis, particularly in Asian countries. OBJECTIVE: To determine the drug survival for ustekinumab in real-life settings and investigate the factors affecting drug survival for psoriasis patients in Korea. METHODS: We evaluated 98 psoriasis patients who were treated with ustekinumab at a single center. We analyzed the efficacy and drug survival of ustekinumab. Cox proportional hazard analysis and competing risk regression analysis were performed to reveal the factors affecting the drug survival of ustekinumab. RESULTS: The overall mean drug survival was 1,596 days (95% confidence interval [CI], 904~2,288). Among the 39 cessations of ustekinumab treatment, 9 (23.1%) patients discontinued treatment after experiencing satisfactory results. Multivariate Cox proportional hazard analysis revealed that paying on patients' own expense was the major predictor for the discontinuation of ustekinumab (hazard ratio [HR], 9.696; 95% CI, 4.088~22.998). Competing risk regression analysis modeling of discontinuation because of factors other than satisfaction of an event also revealed that ustekinumab treatment at the patient's expense (HR, 4.138; 95% CI, 1.684~10.168) was a predictor of discontinuation rather than satisfaction. CONCLUSION: The results of our study revealed that the cost of biologics treatment affects the drug survival of ustekinumab and suggested that economic factors affect the drug survival of ustekinumab treatment in Korea.
Asian Continental Ancestry Group ; Biological Factors ; Biological Products ; Costs and Cost Analysis ; Humans ; Korea* ; Psoriasis* ; Ustekinumab*

Most treatment strategies for asthma currently include inhaled corticosteroids, with the addition of long-acting beta-2-agonists or leukotriene modifiers, if necessary. However, some patients may not respond to conventional treatment. A better understanding of the pathophysiology of asthma has recently led to the development of biological agents, which have shown promising results for symptom control and future risk reduction in severe asthmatics. This article reviews currently available biologic agents, introduces related studies, and describes the subgroup of patients benefitting from each of biologic agents in the view point of precision medicine.
Adrenal Cortex Hormones ; Asthma* ; Biological Factors* ; Biological Therapy ; Humans ; Precision Medicine ; Risk Reduction Behavior