Humans ; Molecular Epidemiology ; Pathology, Molecular ; Precision Medicine

We looked for and discussed the changes of curricula of medical course of 31 medical schools during the period of 1984 and 1993. The data used in this study were Educational State Report of Korean Med ical Schools published from Dean Association of Korean Medical Schools in 1984 and 1992-1993. The significant findings were as follows. 1. There were great variability in number of subjects and in time for lecture and exercise in each subject among 31 medical schools. 2. There were a great deal of changes during the period of 1984 and 1993. There were increased tendency in number of subjects and especially block lectures. Schools which had 1-4 subjects vanished in curriculum were most frequent among 22 schools during 9 years. Name of most frequent subjects in block lecture were clinico-patholo gical conference, reproductive medicine, hematology, oncology and cardiology in 1993. 3. Subjects which were transferred to pre-medical program were classified to two groups. One group was traditional basic medical subjects such anatomy, physiology and biochemistry, the other group was newly introduced subjects such as molecular biology and cell biology as basic medical subjects. 4. The data were suggested that long time was needed to stabilized in newly introduced subjects of clinical medicine such as neurology and plastic surgery. Time for lecture and exercise of these subjects shows increasing tendency in schools established before 1978, but decreasing tendency in schools established after 1978.
Biochemistry ; Cardiology ; Clinical Medicine ; Curriculum* ; Hematology ; Humans ; Lectures ; Molecular Biology ; Neurology ; Physiology ; Reproductive Medicine ; Schools, Medical ; Surgery, Plastic

Molecular imaging in gastroenterology has become more feasible with recent advances in imaging technology, molecular genetics, and next-generation biochemistry, in addition to advances in endoscopic imaging techniques including magnified high-resolution endoscopy, narrow band imaging or autofluorescence imaging, flexible spectral imaging color enhancement, and confocal laser endomicroscopy. These developments have the potential to serve as "red flag" techniques enabling the earlier and accurate detection of mucosal abnormalities (such as precancerous lesions) beyond biomarkers, virtual histology of detected lesions, and molecular targeted therapy-the strategy of "one stone to kill two or three birds"; however, more effort should be done to be "blue ocean" benefit. This review deals with the introduction of Raman spectroscopy endoscopy, imaging mass spectroscopy, and nanomolecule development for theranostics. Imaging of molecular pathological changes in cells/tissues/organs might open the "royal road" to either convincing diagnosis of diseases that otherwise would only be detected in the advanced stages or novel therapeutic methods targeted to personalized medicine.
Biochemistry ; Birds* ; Diagnosis ; Endoscopy ; Gastroenterology* ; Mass Spectrometry ; Molecular Biology ; Molecular Imaging* ; Narrow Band Imaging ; Optical Imaging ; Spectrum Analysis, Raman ; Biomarkers ; Precision Medicine

No abstract available.
Biochemistry* ; Korea*

Biochemistry and Molecular Biology are the cornerstone courses of talent training in the field of life science. Taking these course as an example, this study explored reconstructing the knowledge framework, developing teaching cases, sharing teaching resources, innovating teaching means and establishing ideological education patterns. Supported by the scientific research achievements with discipline characteristics and online teaching platform, this research explored and practiced an integrated curriculum reform mode. This mode is guided by scientific research and education, based on the course development, and driven by communication and cooperation. A shared space of "exchange, practice, openness and informatization" was developed to achieve free and independent integration of undergraduate and graduate teaching motivated by learning knowledge, resulting in an effective student training.
Humans ; Curriculum ; Students ; Learning ; Molecular Biology/education* ; Biochemistry/education*

Bioinformatics is a rapidly emerging field of biomedical research. A flood of large-scale genomic and postgenomic data means that many of the challenges in biomedical research are now challenges in computational sciences. Clinical informatics has long developed methodologies to improve biomedical research and clinical care by integrating experimental and clinical information systems. The informatics revolutions both in bioinformatics and clinical informatics will eventually change the current practice of medicine, including diagnostics, therapeutics, and prognostics.Postgenome informatics, powered by high throughput technologies and genomic-scale databases, is likely to transform our biomedical understanding forever much the same way that biochemistry did a generation ago. The paper describes how these technologies will impact biomedical research and clinical care, emphasizing recent advances in biochip-based functional genomics and proteomics. Basic data preprocessing with normalization, primary pattern analysis, and machine learning algorithms will be presented. Use of integrated biochip informatics technologies, text mining of factual and literature databases, and integrated management of biomolecular databases will be discussed. Each step will be given with real examples in the context of clinical relevance. Issues of linking molecular genotype and clinical phenotype information will be discussed.
Machine Learning ; Biochemistry ; Computational Biology* ; Data Mining ; Genomics ; Genotype ; Informatics ; Information Systems ; Medical Informatics ; Phenotype ; Proteomics

Biochemical characteristics of B. subtilis Du, B. subtilis NT, B. subtilis ATCC 6633 were primarily the same, but their size was smaller with small colonies, R form and opaquely white color. 72 hours was culture duration for obtaining highest amount of amylase in B. subtilis ATCC, while in B. subtilis NT and B. subtilis Du – 96 hours
Bacillus ; Bacillus subtilis ; Biochemistry

In the last 11 years recently the contaminated rate was very low (291/6382 samples). 0.45% and decreased dramatically in the past 3 years (2000-2003 period). The most common contaminated germs were primarily gram(+) bacteria (60% - 195/320 samples). 4.6% of samples were contamined with fungi (15/320), which should be erradicated completely
Biochemistry ; Bacillus subtilis ; Probiotics

The remedy “dang sam” has been used commonly in the traditional oriental medicine to reinforce “khi” (vital energy). Two species of “dang sam” were found in Sapa city (Lao Cai province): a wild one and an acclimatized one. In the current study, the botanical characteristics of the wild “dang sam” were described, and the plant was identified as Codonopsis javanica (Blume) Hook f. The acclimatized “dang sam” also exhibited the characteristics of the Codonopsis genus, and has been planned to be the object of a further study in the future.
Plants ; Medicine, Traditional ; Biochemistry

Both ethanol extracts of the bark and leaves of Schefflera elliptica (Blume) Harms (Araliaceae) showed antistress effect on mice at the oral doses of 158 and 167 mg/kg body weight, respectively. The bark proved to be more effective than the leaves, and their efficacity increased with the doses. Both extracts possessed in vitro antioxidant activity at the concentrations of 50-100 mcg/ml, the bark also being more effective than the leaves. The total saponin extract of the bark exhibited antioxidant effects at the levels of 5-25 mcg/ml. So, saponins might be the chemical constituents determining the antioxidant activity.
Plants ; Biochemistry ; Araliaceae ; Therapeutics