OBJECTIVE: To investigate the effect of several traditional Chinese medicine formula therapies on proliferation of nasopharyngeal carcinoma cell line HNE1. METHOD: The inhibition effect of medicine serums of Qi-Boosting Toxin-Resolving granule on proliferation of NPC cell line HNE1 in vitro was observed by MTT assay. RESULT: The rates of survival cells in Qi-Boosting Toxin-Resolving decoction group and Toxin-Resolving group were the lowest after 48 hours treatment, while Qi-Boosting group, yin-nourishing group, residual-component group medicine serums had the most obvious effects on the rates of survival cells at 72 hours. The inhibition ratio of 15% Qi-Boosting Toxin-Resolving granule medicine serums was 67.68%. CONCLUSION The result of MTT assay showed that cell proliferation was significantly inhibited by Qi-Boosting Toxin-Resolving granule and its separate composes medicine serums. Qi-Boosting Toxin-Resolving granule had the most significantly specific effects. The effects were correlated with serum concentration and treatment time of Qi-Boosting Toxin-Resolving granule and its separate composes medicine.
Animals ; Cell Line, Tumor ; Cell Proliferation ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Medicine, Chinese Traditional ; Nasopharyngeal Neoplasms ; Rats ; Rats, Sprague-Dawley ; Serum

OBJECTIVE: To investigate the behavior difference of allergic rhinitis with adenoid hypertrophy between study group and control group. METHOD: One hundred and seventeen children diagnosed as allergic rhinitis with adenoid hypertrophy were enrolled in our study were divided into study group and control group. Forty-two children treated with local steroid nasal spray for two to three months and antihistamine were control group. Seventy-five children treated with endoscopic adenoidectomy and drug treatment were study group; All children' parents were inquired for their clinical presentation. RESULT: No distinctive differences were found between the two groups (P > 0.05) in adenoid hypertrophy, accompanying nasal problems and clinical questionnaire scoring. Significant statistical distinction were found (P < 0.05) in snoring, sleep disturbance and frequent arousal, nasal obstructive moth-breathing, and recurrent respiratory tract infection between the two groups after three-month follow up. CONCLUSION Endoscopic adenoidectomy should be taken into account for allergic rhinitis with adenoid hypertrophy in children. Adenoidectomy would be useful for the improvement of behavior symptoms.
Adenoidectomy ; methods ; Adenoids ; pathology ; Anti-Allergic Agents ; administration & dosage ; Case-Control Studies ; Child ; Combined Modality Therapy ; Endoscopy ; Female ; Histamine H1 Antagonists ; administration & dosage ; Humans ; Hypertrophy ; complications ; therapy ; Male ; Rhinitis, Allergic ; complications ; therapy ; Steroids ; administration & dosage

OBJECTIVE: To investigate the efficacy of round window catheter placement with dexamethasone perfusion for 13 patients with intractable sudden sensorineural hearing loss (SSNHL). METHOD: Dexamethasone (2.5 mg) was perfused transtympanically through round window catheter by Micro-infusion pump. The perfusion was taken twice a day and continued for an hour each time, for a total of 7 days. RESULT: Thirteen patients have been followed up for 1 month. Five of them (38.5%) were demonstrated a 17-54 dB improvement in pure-tone threshold average (PTA). The other 8 patients (61.5%) had no effect. CONCLUSION Round window catheter placement with dexamethasone perfusion is a cost-effective and useful treatment for SSNHL patients who had no effect through conventional therapy, although hearing thresholds of these patients had hardly improved to normal levels.
Adult ; Aged ; Catheterization ; Dexamethasone ; administration & dosage ; therapeutic use ; Female ; Hearing Loss, Sensorineural ; drug therapy ; Hearing Loss, Sudden ; drug therapy ; Humans ; Male ; Middle Aged ; Round Window, Ear