Objective To investigate the clinical characteristics and diagnosis of some patients with cryptococcus neoformans meningitis(CNM).Methods The clinical features were analyzed and summarized for the findings of 16 CNM cases.Results The clinical cachexia manifestations were not found in the 16 CNM cases.The higher intracranial hypertension and the slight elevation of CSF protein content were found in the earlier period.The cryptococcus neoformans could be found in CSF through lots of lumbar puncture usually.Conclusion The symptom in the earlier period of cryptococcus neoformans meningitis is not typical.It is difficult to find the cryptococcus neoformans.In order to definite the diagnosis,more examinations of CSF must be done.