OBJECTIVETo make a study of the influence of the intervene of traditional Chinese medicine on cytokine level in benign prostatic hyperplasia.

METHODThe patients were divided into treatment group (group A), control group (group B) and healthy group (group C) with the randomly compared researching method. Group A were given Qianliening Tang (QLNT), daily potion, two times a day. Group B were given Qianliekang, three times a day, three pills each time. The course of both treatment lasted for 8 weeks.

RESULTBefore treatment, TNF-alpha, IL-17/IL-10, IL-4 in group A and B are obviously out of order compared with group C (P < 0.01). After the treatment, TNF-alpha, IL-17 in group A decreased dramatically and IL-10, IL-4 increased, which shows great differences compared with those before treatment and with group B (P < 0.01), but still can't reach to group C level.

CONCLUSIONQian liening Tang can efficiently regulate the level of suppressive inflammatory cytokines and proinflammatory cytokines. It provides scientific experimental basis for clinical diagnosis and treatment of the disease.

Adjuvants, Immunologic ; Aged ; Aged, 80 and over ; Cytokines ; blood ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Interferon-gamma ; blood ; Interleukin-10 ; blood ; Interleukin-17 ; blood ; Interleukin-4 ; blood ; Leukocytes, Mononuclear ; drug effects ; Male ; Medicine, Chinese Traditional ; methods ; Middle Aged ; Phytotherapy ; Prostatic Hyperplasia ; blood ; drug therapy ; RNA, Messenger ; Synovial Membrane ; drug effects ; Tumor Necrosis Factor-alpha ; blood