Objective:To survey the knowledge levels of sudden cardiac death (SCD) prevention among general practitioners (GPs) in Henan province.Methods:From October to November 2019, a questionnaire survey on the knowledge of SCD prevention and treatment was conducted among GP residents participating in the standardized training and assistant GPs taking final examination after training in Henan province. The questionnaire included three dimensions of SCD knowledge: prevention, early diagnosis and first aid. The factors influencing the knowledge levels on SCD prevention were analyzed.Results:A total of 546 questionnaires were distributed and 519 responders (95.1%) completed the questionnaire, including 176 GP residencies and 343 assistant GPs. The age of the respondents was 22-44 (27.91±2.84) years, 234 (45.1%) were males and 285 were females. The overall correct rate of SCD prevention and treatment was (61.46±12.39) %, and the correct rates of prevention, early diagnosis and first aid knowledge were (65.22±17.88)%, (56.58±20.20)% and (62.57±14.60)%, respectively. The overall correct rate and the correct rates of SCD prevention and treatment knowledge among GP residents were higher than those among assistant GPs ( t=10.55, 9.20, 8.62, 3.42, P<0.001); the overall correct rates and the correct rates of SCD first aid knowledge of female GPs were higher than those of males ( t=2.26, 2.13, P=0.025, 0.033); the overall correct rate and the correct rates of each dimensions in age group ≥28 years were higher than those in age group <28 years ( t=4.21, 3.37, 3.20, 2.00, P<0.05). The multivariate logistic regression analysis showed that compared to GP residents,the assistant GPs was the factor influencing the lower levels of the overall knowledge ( OR=0.24, 95 %CI:0.16-0.38, P<0.001), knowledge of prevention ( OR=0.19, 95 %CI:0.10-0.32, P<0.001) and knowledge of early diagnosis ( OR=0.35, 95 %CI: 0.23-0.52, P<0.001);compared to male responders,the females had significantly higher pass rate in SCD first aid knowledge ( OR=1.56, 95 %CI:1.07-2.28, P=0.020). Conclusions:The SCD knowledge levels of the prevention, early diagnosis, and emergency treatment are less satisfactory among GPs in Henan province; it is necessity for targeted training on the weak points of SCD knowledge for GPs.

Objective:To survey on the knowledge, attitude and prescribing of benzodiazepines (BZDs) among general practitioners.Methods:A questionnaire survey was conducted in November 2018 among 396 clinicians who participated in the general practice training in Henan Province, including 131 general practitioners (GP group) and 265 non-GPs (non-GP group). The questionnaire included basic information of clinicians, BZDs prescription and training, subjective attitude and knowledge of BZDs.Results:The results of 396 valid questionnaires showed that 55 (13.9%) clinicians had participated in BZDs related training, and 331 (83.6%) clinicians had prescribed BZDs. There was no significant difference in the duration of BZDs continuous use between the GP group and the non-GP group (χ 2= 8.37, P>0.05). The overall score of subjective attitude towards BZDs was low [4(2,6) - 5(3,9)], and the score of BZDs training needs was high [10(8,10)]. Compared to non-GP group, the GP group had lower confidence in BZDs indication [4(2,6) vs. 5(3,6), Z=-2.66, P<0.05 ], the lower ability of judging BZDs addiction [5(2,6) vs. 5(3,7), Z=-2.52, P<0.05], and less understanding of BZDs use guidelines [4(1,5) vs. 4(3,6), Z=-3.05, P<0.05]. In terms of prescription tendency, the GP group was less inclined to prescribe BZDs according to experience [5(2,7) vs. 6(4,8), Z=-3.50, P<0.05]. In the knowledge of BZDs, the total score of GP group was lower than that of non-GP group, the [11(8,12) vs. 11(9,13), Z=-2.06, P<0.05]. The proportion of GPs with drug addiction recognition[66.4%(87/131) vs.77.7%(206/265),χ 2=5.84] and pharmacology knowledge [59.5%(78/131) vs.72.1%(191/265),χ 2=6.32] were all lower than that of non-GPs( P<0.05). Conclusions:General practitioners are lack of knowledge about BZDs and confidence in prescribing BZDs. It is necessary to carry out training on BZDs, especially for addiction and drug effects.

Sudden cardiac death (SCD) is one of the most common causes of death for patients with cardiovascular diseases. General practitioners are the providers of primary medical and health service, it its worthwhile to discuss their role positioning in the prevention and control system of SCD. In this study, SWOT analysis was used to explore the strength, weakness, opportunity and threats of the involvement of general practitioners in SCD prevention and control system, to clarify the roles of general practitioners and to provide suggestions for the improvement and development of SCD prevention and control system in China.

Objective To explore the effective constituents from Sonchus arvensis L. and the potential mechanism in treating sepsis by network pharmacology. Methods The chemical ingredients reported in the literature were taken as research objects and Swiss Target Prediction database was used to collect the identify the potential targets of those ingredients. The GeneCards, OMIM and TTD databases were applied to screen the sepsis related molecular targets. The cross targets were obtained and used to construct the active ingredient-disease target network. In addition, the targets were also imported into STRING database to construct a PPI network. Finally, GO and KEGG enrichment analysis were performed on the target genes to predict the mechanism via DAVID database. Results 71 components from S. arvensis L. were obtained, which corresponded to 579 potential drug targets. There were 3437 related targets of sepsis. S. arvensis L. and sepsis shared 272 common targets. The results showed that 1366 terms were found by GO function enrichment, including 245 molecular functions (MF), 1002 biological processes (BP), and 119 cell composition (CC), The KEGG enrichment analysis suggested that 166 signaling pathways were involved. Conclusion The study revealed that TNF, AKT1, IL-6, IL-1β, TP53 and some other targets might be affected by potentially active ingredients of S arvensis L. such as linoleic acid, linolenic acid and oleic acid to regulate the expression of steroids, sphingolipids hormones as well as epidermal factors and chemokines in treating sepsis.