CMTM family is silenced and down-regulated in several kinds of tumors.Its aberrant expression has a strong association with the development,progression and metastasis of tumors.Thus,CMTM family is potential tumor suppressor genes.Epigenetics mechanism is the essential mechanism of the aberrant expression in this gene family.The discovery of this research gives a new direction to the clinical treatment of tumor.

Exosome microRNA is closely related to the pathological processes of multiple sclerosis.Recent studies have shown that exosome microRNA is not only involved in the pathogenesis of multiple sclerosis,but also plays an important role in the early diagnosis,the identification of relapses,the prediction of subtypes and the treatment of multiple sclerosis.Therefore,exosome microRNA is expected to be a new diagnostic biomarker as well as treatment target for multiple sclerosis.In this article,the advances of exosome microRNA in multiple sclerosis are reviewed.